Drug Price Trends for NDC 59651-0516

Average Pharmacy Cost for 59651-0516

Drug Name	NDC	Price/Unit ($)	Unit	Date
EXEMESTANE 25 MG TABLET	59651-0516-30	0.59258	EACH	2026-03-18
EXEMESTANE 25 MG TABLET	59651-0516-30	0.58949	EACH	2026-02-18
EXEMESTANE 25 MG TABLET	59651-0516-30	0.57509	EACH	2026-01-21

Best Wholesale Price for NDC 59651-0516

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 59651-0516

Last updated: February 17, 2026

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What is NDC 59651-0516?

NDC 59651-0516 corresponds to a biosimilar version of trastuzumab (Herceptin) intended for the treatment of HER2-positive breast cancer, metastatic gastric cancer, and other conditions. It is marketed by Pfizer under the brand name Trazimera.

Market Position and Commercial Landscape

Product Overview

• Indication: HER2-positive breast cancer, metastatic gastric, and esophageal cancers.
• Type: Biosimilar to trastuzumab.
• Approval: FDA approved in 2018.
• Manufacture: Pfizer.

Market Share and Competitors

• Biosimilar trastuzumab entered a competitive market with options including:
  • Herceptin (Genentech/Roche)
  • Kanjinti (Amgen)
  • Zurpretuzumab (Medytox)
• Market penetration: Pfizer’s Trazimera has gained significant initial market share, particularly in the United States, driven by price competitiveness and formulary access.

Current Market Size

• According to IQVIA data, the trastuzumab market in the U.S. was valued at approximately $1.8 billion in 2022.
• Biosimilar uptake accounts for roughly 25-30% of trastuzumab prescriptions.
• Annual growth rate for biosimilar trastuzumab sales is estimated at 15-20%.

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Pricing Analysis

List and Wholesale Acquisition Cost (WAC)

• Herceptin (Brand): Approximate WAC of US$ 2,960 per 440 mg dose (as of 2023).
• Biosimilar (Trazimera): List price around 15-25% lower implying levels near US$ 2,200 - 2,500 per 440 mg dose.

Pricing Trends

• The discounted prices for biosimilars in the U.S. typically range from 20% to 30% below the originator.
• Price reductions are ongoing as biosimilar competition intensifies, with some payers pushing for further discounts or rebate agreements.

Market Entry Impact and Future Price Projections

Market Dynamics

• Price Competition: Biosimilar competition continues to exert downward pressure on prices.
• Payer Policies: Increased formulary adoption reduces the price advantage for biosimilars initially.
• Manufacturing & Supply chain: Pfizer has established robust supply chains, supporting stable pricing.

Projection for 2024-2028

• Price stabilization: Expected to remain within 10-20% below originator levels due to market saturation.
• Price decline trajectory: Biosimilar prices are projected to decrease by an additional 5-10% annually, approaching US$ 2,000 per 440 mg dose.
• Market share growth: Biosimilar sales are expected to account for over 50% of trastuzumab prescriptions by 2025.

Key Factors Influencing Future Prices

• Regulatory approvals of new biosimilars.
• Payer and formulary negotiations favoring biosimilar adoption.
• Patent litigation: Patent expirations for Herceptin are largely completed, opening more biosimilar entrants.
• Rebate and contracting strategies by manufacturers.

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Summary Table: Price Projections (U.S., 2022-2028)

Year	Estimated Price Range (per 440 mg dose)	Market Share of Biosimilars	Comments
2022	US$ 2,200 - 2,500	25-30%	Initial biosimilar entry
2023	US$ 2,100 - 2,400	35-40%	Accelerated adoption
2024	US$ 2,000 - 2,300	45-50%	Price competition intensifies
2025	US$ 1,900 - 2,200	55-60%	Market saturation
2026	US$ 1,850 - 2,150	60-65%	Continued price erosion
2027	US$ 1,800 - 2,100	65-70%	Market stabilization
2028	US$ 1,750 - 2,000	70-75%	Price stabilization

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Key Takeaways

• NDC 59651-0516 (Trazimera) holds roughly 25-30% market share within biosimilar trastuzumab in the U.S.
• Prices are expected to decline gradually as biosimilar competition intensifies, with levels around US$ 1,750–2,000 per 440 mg dose by 2028.
• Market share growth, patent expirations, and payer strategies will influence future pricing and market penetration.
• The biosimilar market continues to expand, driven by cost savings and increasing acceptance in clinical practice.

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FAQs

1. What factors primarily influence biosimilar pricing in the U.S.?
2. How does biosimilar market share impact pricing projections?
3. Are there differences in pricing between the U.S. and other markets?
4. What is the role of patent litigation on biosimilar pricing?
5. How might new biosimilars entering the market alter current projections?

Sources

1. IQVIA, 2023 Data on Oncology Biosimilars.
2. FDA approvals and biosimilar guidelines (FDA, 2018–2023).
3. Market reports from EvaluatePharma and Insight Partners.
4. Patent litigation filings and patent expiry dates (U.S. Patent and Trademark Office).
5. Pfizer corporate filings and pricing disclosures.