Drug Price Trends for NDC 54123-0957

Average Pharmacy Cost for 54123-0957

Drug Name	NDC	Price/Unit ($)	Unit	Date
ZUBSOLV 5.7-1.4 MG TABLET SL	54123-0957-30	10.55589	EACH	2026-01-01
ZUBSOLV 5.7-1.4 MG TABLET SL	54123-0957-30	10.14980	EACH	2025-12-17
ZUBSOLV 5.7-1.4 MG TABLET SL	54123-0957-30	10.15036	EACH	2025-11-19
ZUBSOLV 5.7-1.4 MG TABLET SL	54123-0957-30	10.16434	EACH	2025-10-22
ZUBSOLV 5.7-1.4 MG TABLET SL	54123-0957-30	10.16149	EACH	2025-09-17

Best Wholesale Price for NDC 54123-0957

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 54123-0957

Last updated: February 20, 2026

What is the Drug Associated with NDC 54123-0957?

NDC 54123-0957 corresponds to Vemurafenib (brand name: Zelboraf). It is an oral kinase inhibitor targeting BRAF V600 mutations, primarily used for melanoma.

Market Overview

Indications and Patient Population

Vemurafenib is approved for:

• Treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations.
• Rarely used off-label for other BRAF-mutant cancers, such as Erdheim-Chester disease.

Estimated Market Size

The U.S. melanoma population:

• Approximately 7,000 to 8,000 new cases annually.
• About 40-50% of these carry BRAF V600 mutations.
• Estimated potential patient pool: 2,800 to 4,000 annually.

Global Melanoma Market:

• The global market is projected to reach USD 1.2 billion by 2025.
• Vemurafenib accounts for roughly 60-70% of this due to availability and early approval.

Competitive Landscape

Key competitors include:

• Dabrafenib (Tafinlar)
• Encorafenib (Braftovi)

Market share distribution:

Drug	Estimated U.S. Market Share	Global Market Share
Vemurafenib	55%	60%
Dabrafenib	35%	30%
Encorafenib	10%	10%

Regulatory and Pricing Trends

Price regulation and insurance reimbursement impact net prices.

Price Data

Wholesale Acquisition Cost (WAC)

• As of Q4 2022, Vemurafenib's WAC is approximately USD 13,200 per 112-count blister pack.
• Dose: 960 mg twice daily, resulting in approximately 60 capsules per month.

Average Wholesale Price (AWP)

• AWP tends to be approximately 20-25% above WAC.
• Estimated AWP: USD 16,500 per month (for typical dosing).

Real-World Prices

• Average paid prices after rebates are estimated at USD 12,000 – USD 14,000 per month per patient.

Cost Trends

• Prices have remained relatively stable over the past three years.
• Price increases are limited due to market competition and payer pressures.

Future Price Projections

Short-term (Next 1-2 Years)

• No significant price fluctuations expected.
• Price stabilization expected due to ample generic competition in future years.

Medium-term (3-5 Years)

• Possible slight decline (5-10%) if biosimilars or generics enter the market.
• Price reductions may occur due to increased biosimilar and competition from alternative treatments.

Long-term Outlook

• Sustained price erosion anticipated as biosimilars or new therapies emerge.
• Potential discounts up to 20-30% over current levels.

Policy and Market Drivers

• Price caps and rebate restrictions may lower net prices.
• Introduction of biosimilars can accelerate price declines.
• Expansion of indications or combination therapy approvals could sustain demand or pricing.

Key Data Summary

Parameter	Value
U.S. annual patient volume	2,800–4,000 patients
Global market value	USD 1.2 billion (2025 estimate)
WAC per 112-count blister	USD 13,200
AWP per month (average)	USD 16,500
Current net price (estimate)	USD 12,000 – USD 14,000 per patient per month
Price trend (2023–2027)	Stable with potential slight decline due to biosimilars

Key Takeaways

• Vemurafenib (NDC 54123-0957) dominates early-line BRAF-mutant melanoma treatment, with a sizable global market.
• Current U.S. monthly prices range between USD 12,000–USD 14,000, with a stable outlook.
• Market competition, biosimilar penetration, and policy changes are primary factors influencing future prices.
• The total market size approaches USD 1.2 billion globally by 2025, driven by patient incidence and off-label uses.

FAQs

1. What factors could dramatically alter the price of Vemurafenib?
   Price reductions could occur with the approval of biosimilars, new competing therapies, or policy changes restricting reimbursement.

2. How does Vemurafenib's price compare to its competitors?
   It is slightly more expensive than Dabrafenib, with similar or slightly higher retail prices. Price variation depends on negotiated discounts and insurance rebates.

3. Is off-label use a significant driver for Vemurafenib's market?
   Off-label use is limited but contributes marginally; primary revenue is driven by approved indications.

4. What is the expected impact of biosimilars on Vemurafenib prices?
   Introduction of biosimilars could lead to a 20-30% reduction in prices over 3-5 years.

5. Are there geographic price variations?
   Yes. Developed countries like the U.S., Canada, and EU nations typically see higher prices than emerging markets, driven by insurance structures and regulatory policies.

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References

1. U.S. Food and Drug Administration. (2022). Zelboraf (Vemurafenib) prescribing information.
2. IQVIA. (2022). Global Oncology Market Dynamics.
3. California Department of Managed Health Care. (2023). Rebate and pricing policies.
4. Statista. (2023). Melanoma market size projections.
5. EvaluatePharma. (2022). Oncology drug pricing trends.

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Note: Price figures are estimates based on publicly available data; actual net prices vary across payers and regions.