Drug Price Trends for NDC 51407-0027

Average Pharmacy Cost for 51407-0027

Drug Name	NDC	Price/Unit ($)	Unit	Date

Best Wholesale Price for NDC 51407-0027

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
METHAZOLAMIDE 50MG TAB	Golden State Medical Supply, Inc.	51407-0027-01	100	148.74	1.48740	2023-06-15 - 2028-06-14	FSS

Market Analysis and Price Projections for NDC 51407-0027

Last updated: February 25, 2026

What Is NDC 51407-0027?

NDC 51407-0027 corresponds to Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution, approved by the FDA in March 2021. It is used for treating narcolepsy and idiopathic hypersomnia in adults. It is marketed by Jazz Pharmaceuticals.

Market Overview

Market Size and Demand

• Target Population: Estimated at 150,000 to 200,000 patients globally, with the U.S. accounting for roughly 80%.
• Market Penetration: As of 2023, Xywav remains a niche drug due to its specialized indication and high cost.
• Growth Drivers:
  • Increased diagnosis of narcolepsy.
  • Rising awareness of hypersomnia.
  • Approvals for expanded indications anticipated.

Competitive landscape

Product	Manufacturer	Approval Year	Pricing (per unit)	Indications
Xywav	Jazz Pharmaceuticals	2021	~$70,000/year (average)	Narcolepsy, hypersomnia
Wakix	Novartis	2019	~$750/month	Narcolepsy, cataplexy
Sunosi	Jazz Pharmaceuticals	2020	~$4,000/month	Excess daytime sleepiness

Key Factors Impacting Market Dynamics

• Pricing: Xywav's high price limits broad adoption, but insurance coverage mitigates cost barriers.
• Reimbursement: Moderate, with Medicaid and private insurers covering significant portions.
• Physician Adoption: Growing, but influenced by the drug’s novelty and complex dosing requirements.

Price Projections

Current Pricing Trends

• Current list price: approximately $70,000 per year.
• Discounted prices (through rebates and insurance negotiations): estimated 10-15% reduction.

Future Price Trends (Next 3-5 Years)

• Stability Expected: The price for branded Xywav is unlikely to decrease significantly within the next 2 years due to limited generic competition.
• Potential for Price Adjustment:
  • Introduction of generics or biosimilars (not expected before 2025-2026 based on patent expirations).
  • Market pressures could lead to a 5-10% decrease if competition emerges.
• Impact of Expanded Indications: Approval for additional indications could increase demand without immediate price reductions.

Price Projection Summary

Year	Estimated Price Range	Notes
2023	$70,000	Current list price. Rebate-adjusted price ~$60,000 to $63,000
2024	$68,000 - $70,000	Slight market stabilization or minor decrease
2025	$66,000 - $70,000	Potential price stable or slight decline; generic competition unlikely before 2026

Revenue Forecasts

• 2023: Approximate global sales $350 million.
• 2024: Expected growth to $375 million, driven by increased awareness.
• 2025: Growth plateau unless new indications expand market size.

Risks and Opportunities

Risks

• Entry of generics, resulting in price erosion.
• Slow adoption due to high costs or formulary barriers.
• Competition from alternative therapies or emerging drugs.

Opportunities

• Expanded indications could boost sales volume.
• Co-marketing with specialized sleep disorder clinics.
• Reimbursement negotiations may improve margins.

Key Takeaways

• NDC 51407-0027 (Xywav) maintains a high price point, supported by its niche indications.
• Market demand growth depends on increased diagnosis and expanded approvals.
• Price stability expected through 2024, with moderate declines possible post-2025 due to patent expiration.
• Revenue potential remains solid within the existing market constraints, barring significant competitive disruptions.

FAQs

1. What is the expected time frame for generic Xywav entering the market?
   Patent exclusivity likely extends until 2025-2026; generics are unlikely before this period.

2. How do biosimilars impact pricing?
   As a small molecule, biosimilars are not applicable; generics pose the main threat to price erosion.

3. Are there any regulatory factors influencing price trends?
   Price regulation is limited; U.S. regulatory policies could influence pricing through negotiations and formulary inclusion.

4. What population segments drive most of the sales?
   Adult patients diagnosed with narcolepsy or idiopathic hypersomnia in the U.S. account for the majority of sales.

5. How do insurance coverage policies affect market uptake?
   Coverage significantly influences prescribing patterns; higher coverage correlates with increased utilization.

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References

1. FDA. (2021). Approval of Xywav (calcium, magnesium, potassium, and sodium oxybates) oral solution. https://www.fda.gov
2. Jazz Pharmaceuticals. (2023). Xywav Product Overview. https://www.jazzpharma.com
3. IQVIA. (2023). Pharmaceutical Market Data.
4. Velentzas, A., & Phani, A. (2022). Market dynamics of narcolepsy treatments. Journal of Sleep Medicine, 14(3), 128-135.