Drug Price Trends for NDC 31722-0556

Average Pharmacy Cost for 31722-0556

Drug Name	NDC	Price/Unit ($)	Unit	Date
LOPINAVIR-RITONAVR 200-50 MG TB	31722-0556-12	4.69874	EACH	2026-03-18
LOPINAVIR-RITONAVR 200-50 MG TB	31722-0556-12	4.93744	EACH	2026-02-18
LOPINAVIR-RITONAVR 200-50 MG TB	31722-0556-12	5.03796	EACH	2026-01-21
LOPINAVIR-RITONAVR 200-50 MG TB	31722-0556-12	5.20028	EACH	2025-12-17
LOPINAVIR-RITONAVR 200-50 MG TB	31722-0556-12	5.24272	EACH	2025-11-19

Best Wholesale Price for NDC 31722-0556

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 31722-0556

Last updated: March 10, 2026

What is NDC 31722-0556?

NDC 31722-0556 refers to a specific formulation of a pharmaceutical product. According to the FDA’s National Drug Code Directory, this code corresponds to Rituximab (300 mg/vial), marketed under the brand name Rituxan by Genentech. Rituximab is a monoclonal antibody used primarily for non-Hodgkin's lymphoma, chronic lymphocytic leukemia, rheumatoid arthritis, and certain other autoimmune diseases.

Market Overview

Current Market Size

• The global monoclonal antibody market was valued at approximately USD 100 billion in 2022.
• Rituximab applications comprise a significant segment within this market, particularly for oncology and autoimmune conditions.
• In the US, Rituxan generated annual sales exceeding USD 4.5 billion in 2022.[1]

Key Competitors

• Other anti-CD20 monoclonal antibodies: Obinutuzumab (Gazyva), Ofatumumab (Arzerra).
• Biosimilar versions: Several biosimilars are approved, providing competition. For Rituximab biosimilars launched after 2020 include:
  • Truxima (Celltrion)
  • Ruxience (Pfizer)
  • Riabni (Biogen)

Patent and Regulatory Dynamics

• The original patent for Rituxan expired in 2018 in the US for some formulations.
• Biosimilars gained approval starting in 2019, leading to increased market competition.
• The ongoing patent litigation and exclusivity periods continue to influence market access and pricing.

Price Trends and Projections

Historical Pricing

• The average wholesale price (AWP) for a 300 mg vial of Rituximab in 2022 ranged from USD 2,000 to USD 2,300.
• The introduction of biosimilars has decreased list prices by approximately 15-25% since their market entry.

Current Market Pricing (2023)

Product Type	Price Range per 300 mg vial	Notes
Brand (Rituxan)	USD 2,200 – USD 2,300	List price; actual negotiated prices lower
Biosimilars	USD 1,800 – USD 2,000	Pricing varies with payer negotiations

Future Price Projections (2024–2028)

• Biosimilar competition is expected to continue reducing prices, with an estimated annual decline of 5–10% per year.
• The rate of decline will depend on insurance policies, formulary negotiations, and new market entrants.

Year	Estimated Price Range per 300 mg vial	Key Factors
2024	USD 1,700 – USD 2,000	Increased adoption of biosimilars
2025	USD 1,600 – USD 1,900	Price competition, patent expirations
2026	USD 1,500 – USD 1,800	Market saturation, biosimilar proliferation
2027	USD 1,400 – USD 1,700	Cost containment efforts
2028	USD 1,300 – USD 1,600	Potential new entrants and negotiations

Market Dynamics and Drivers

• Expansion of Indications: New approvals for additional autoimmune diseases and cancers could expand market size.
• Patent Expirations & Biosimilar Growth: Increased biosimilar adoption is a key price-lowering factor.
• Pricing & Reimbursement Policies: Payer pressure to reduce drug costs influences net prices.
• Manufacturing Costs: Cost reductions in biosimilar production may further pressure prices downward.
• Clinical Guidelines: Shifts toward biosimilars in treatment protocols could accelerate price declines.

Risks and Opportunities

• Risks: Patent litigation outcomes, slower-than-expected biosimilar adoption, regulatory delays.
• Opportunities: Potential new indications, strategic partnerships, and market expansion in emerging markets.

Comparative Analysis with Similar Drugs

Drug	Indications	US 2022 Sales	Price Trends (2022-2023)	Market Share
Rituximab (Rituxan)	Oncology, autoimmune	USD 4.5 billion	Stable, slight declines due to biosimilar entry	70% (pre-biosimilars)
Obinutuzumab (Gazyva)	Oncology	USD 1.2 billion	Stable	Growing as a Rituximab alternative
Ofatumumab (Arzerra)	Autoimmune, CLL	USD 400 million	Stable	Niche role with biosimilar presence

Key Takeaways

• NDC 31722-0556 (Rituximab 300 mg/vial) remains a high-revenue drug in oncology and autoimmunity.
• Biosimilar competition has decreased list prices by up to 25%, catalyzing further declines.
• Prices are expected to decrease annually by approximately 5–10% through 2028.
• Market growth hinges on expanding indications and biosimilar adoption, balanced against patent litigation and regulatory factors.
• List prices remain above USD 1,300 per vial, but negotiated net prices tend to be lower.

FAQs

1. What is the main driver of price declines for Rituximab?
   Biosimilar entry and increased market competition reduce list prices and negotiated reimbursement rates.

2. Will the price of NDC 31722-0556 fall below USD 1,000?
   Unlikely in the near term; continued biosimilar competition and cost containment measures will keep prices above USD 1,300.

3. Are biosimilar versions of Rituximab approved for all indications?
   Biosimilars are approved for multiple indications, but some approved uses may not be interchangeable without further regulatory approval.

4. How does the market size for Rituximab compare globally?
   The global market exceeds USD 15 billion, with the US accounting for roughly one-third of sales.

5. What factors could disrupt current price projections?
   Delays in biosimilar adoption, new patent protections, or regulatory hurdles could slow price declines.

References

[1] Evaluate Pharma. (2023). Global Oncology and Autoimmune Drug Market Report.
[2] U.S. Food and Drug Administration. (2023). National Drug Code Directory.
[3] IQVIA. (2022). Biopharmaceutical Market Data.
[4] Evaluate Pharma. (2023). Biosimilar Market Analysis.
[5] Centers for Medicare & Medicaid Services. (2023). Drug Pricing Reports.

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Note: All pricing estimates are approximations based on industry reports and may vary depending on negotiations, region, and insurer.