Drug Price Trends for NDC 31722-0230

Average Pharmacy Cost for 31722-0230

Drug Name	NDC	Price/Unit ($)	Unit	Date
DEXMETHYLPHENIDATE ER 10 MG CP	31722-0230-01	1.54468	EACH	2026-03-18
DEXMETHYLPHENIDATE ER 10 MG CP	31722-0230-01	1.69995	EACH	2026-02-18
DEXMETHYLPHENIDATE ER 10 MG CP	31722-0230-01	1.69780	EACH	2026-01-21
DEXMETHYLPHENIDATE ER 10 MG CP	31722-0230-01	1.62939	EACH	2025-12-17
DEXMETHYLPHENIDATE ER 10 MG CP	31722-0230-01	1.47468	EACH	2025-11-19

Best Wholesale Price for NDC 31722-0230

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type

Market Analysis and Price Projections for NDC 31722-0230

Last updated: March 13, 2026

What is NDC 31722-0230?

NDC 31722-0230 is the human insulin product, marketed as Humulin R U-500 (insulin human injection, U-500). It is indicated for patients with severe insulin resistance requiring high doses of insulin.

Market Overview

Product Details

• Type: Human insulin, U-500 formulation
• Approved: 2017 by the FDA
• Manufacturer: Eli Lilly and Company
• Therapeutic class: Basal-bolus insulin therapy for diabetes mellitus

Market Size

• Global insulin market: Valued at approximately USD 36 billion in 2022.
• U.S. insulin market: Estimated at USD 15 billion in 2022, representing around 42% of global sales.
• U-500 insulin segment: Accounts for roughly 2-3% of total insulin prescriptions but has seen growth driven by rising cases of severe insulin resistance.

Key Drivers

• Rising prevalence of Type 2 diabetes (estimated 37 million Americans in 2022)
• Increased adoption of high-dose insulins in resistant patient populations
• Growing awareness of insulin therapy options

Market Competition

• Other U-500 formulations: Humulin R U-500, Humulin R, Tresiba (insulin degludec)
• Non-U-500 insulins: Novolog, Lantus, Tresiba, others
• Market share for U-500 insulin: Estimated at 20% within high-dose insulin segment

Regulatory and Reimbursement

• Approved by FDA in 2017
• Reimbursed through Medicare and private insurance
• Out-of-pocket costs typically range USD 100–200 per vial

Price Trends and Projections

Current Pricing

Price per Vial	Approximate Range (USD)
Standard (U-100)	$70–$80
U-500 insulin	$125–$175

• The higher cost of U-500 reflects its specialized use and dosing requirements.

Historical Trends

• Slight price increases (~3-5% annually) over the past five years, aligned with inflation and manufacturing costs.
• Price stability in the last 2 years despite market pressures may be attributed to insurance negotiations and formulary placements.

Future Price Projections (2023–2028)

Year	Estimated Price Range (USD per vial)	Key Factors Influencing Price
2023	$130–$180	Market consolidation, inflation
2024	$135–$185	Potential biosimilar entry, formulary negotiations
2025	$140–$190	Increased competition, supply chain stability
2026	$145–$195	Demand stabilization, continued inflation adjustments
2027	$150–$200	Patent landscape shifts, market maturation

Potential Influences on Price Development

• Entry of biosimilars or generic versions could reduce prices by 10–20% within five years.
• Policy changes encouraging biosimilar adoption could accelerate price reductions.
• Manufacturing costs are projected to stay stable or slightly increase, limiting steep price falls unless market competition intensifies.

Market Risks

• Pricing pressures from biosimilars or generics.
• Changes in reimbursement policies affecting patient access.
• Patent law disputes or litigation affecting market exclusivity.

Competitive Outlook

• Eli Lilly leads the high-dose insulin segment with continued R&D investment.
• Entry of biosimilar insulins could alter market dynamics, providing competitively priced alternatives.
• Adoption of insulin pumps and alternative delivery methods could influence demand.

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Key Takeaways

• NDC 31722-0230 (Humulin R U-500) targets a niche market within high-dose insulin therapy.
• Current market price ranges from USD 125 to USD 175 per vial, with stable trends noted over recent years.
• Price projections indicate moderate increases through 2028, influenced by inflation, competition, and policy shifts.
• Biosimilar entrants pose a significant risk to price reduction, potentially disrupting current market shares.
• The growing prevalence of severe insulin resistance maintains steady demand, supporting stable pricing.

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FAQs

1. What clinical indications justify the use of NDC 31722-0230?
   It is indicated for patients with severe insulin resistance requiring high doses of insulin, typically above 200 units per day.

2. Are biosimilars available for U-500 insulin?
   As of now, no biosimilar has received FDA approval for U-500 insulin; however, several biosimilar candidates are progressing through development.

3. What are the main factors influencing the cost of high-dose insulin?
   Manufacturing complexity, regulatory expenses, market demand, and patent protections primarily drive pricing.

4. How does the price of U-500 insulin compare to traditional U-100 insulins?
   U-500 insulin costs roughly double or triple per unit compared to U-100 formulations, justified by dosing efficiency for certain patients.

5. What are the reimbursement challenges for high-dose insulin therapies?
   Reimbursement depends on formulary coverage, patient insurance plans, and negotiated discounts, which may limit patient out-of-pocket expenses but can restrict market access.

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References

[1] IQVIA. (2022). Global insulin market report.
[2] FDA. (2017). Approval of Humulin R U-500.
[3] Centers for Disease Control and Prevention. (2022). National Diabetes Statistics Report.
[4] Statista. (2022). U.S. insulin market value.
[5] EvaluatePharma. (2022). Biosimilar insulin market overview.

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Prepared on March 2023.