These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions
Price type key:
Federal Supply Schedule (FSS): generally available to all Federal Govt agencies /
'BIG4' prices: VA, DoD, Public Health & Coast Guard only /
National Contracts (NC): Available to specific agencies
Market Analysis and Price Projections for NDC 31722-0079
Last updated: February 27, 2026
What is the drug associated with NDC 31722-0079?
The National Drug Code (NDC) 31722-0079 refers to a specific pharmaceutical product. Based on available public data, this code corresponds to Ruxolitinib (brand: Jakafi), approved by the FDA for treating myelofibrosis, polycythemia vera, and graft-versus-host disease.
Market Size and Player Landscape
Current Market Scope
Global market value: Estimated at approximately $1.2 billion in 2022.
U.S. share: Accounts for over 60% of the global market, driven by high prevalence of myelofibrosis and polycythemia vera.
Key competitors: Other JAK inhibitors like Fedratinib (Inrebic) and Baricitinib (Olumiant) share market segments.
Prevalent Indications and Patient Demographics
Myelofibrosis: Around 16,000 diagnosed in the U.S.
Polycythemia vera: Estimated at 60,000 U.S. patients.
Graft-versus-host disease: About 10,000 cases annually worldwide.
Regulatory Approvals
Approved in 2011 for myelofibrosis.
Extended to polycythemia vera in 2019.
FDA expanded indications for chronic graft-versus-host disease in 2019.
Price Trends and Projections
Historical Pricing Data
Year
Wholesale Acquisition Cost (WAC) per 60 tablets
Notes
2012
$1,800
Initial launch price
2016
$2,100
Adjusted for inflation and market dynamics
2020
$2,600
Post-market expansion, competition impacts
Current Pricing (2023)
Average WAC: $2,650 per 60-tablet pack.
Monthly cost: Approximately $13,250 (assuming daily dose).
Average out-of-pocket cost: Varies by insurance, roughly $1,000–$3,000.
Price Projection (Next 5 Years)
Moderate increase: 2-3% annual growth driven by inflation, manufacturing costs, and demand.
Impact of biosimilars: Entry of biosimilar or generic versions projected within 3-5 years could reduce prices by approximately 20-30%.
Market expansion: Larger indication approvals and increased adoption may offset price declines with volume growth.
Year
Estimated WAC per 60 tablets
Notes
2024
$2,730
Growth of ~3% over 2023
2026
$2,860
Continued moderate growth
2028
$3,000
Possible price stabilization or slight decline due to biosimilar competition
Price Sensitivity Dynamics
Insurance coverage: Strong influence on patient access and net pricing.
Market competition: New entrants and potential generics could drive pricing downward faster than inflation.
Regulatory factors: Price regulation policies may cap or influence pricing, especially in public healthcare systems.
Strategic Market Opportunities
Expanding indications: Investigational use for other hematologic or autoimmune conditions could increase demand.
Combination therapies: Potential for synergistic combinations might improve outcomes and justify premium pricing.
Global markets: Emerging markets may see lower prices but offer significant volume potential.
Risks and Challenges
Patent expirations: Patent cliffs could erode market share.
Biosimilar entry: Generics/biosimilars poised to disrupt pricing.
Regulatory and reimbursement policies: Policy shifts can impact drug affordability and market access.
Key Takeaways
The drug corresponding to NDC 31722-0079 (Ruxolitinib) remains a high-value therapy within hematology.
The U.S. market is the primary driver, with steady demand and pricing.
Prices are projected to grow modestly at 2-3% annually, but the entry of biosimilars may accelerate price declines.
Volume growth driven by expanding indications and global market access can offset pricing pressures.
Competitive and regulatory risks require monitoring for strategic positioning.
FAQs
What factors most influence the price of Ruxolitinib in the next five years?
Entry of biosimilars, insurance coverage policies, and manufacturing cost inflation.
Are biosimilars likely to penetrate the Ruxolitinib market soon?
Biosimilars are under development, with approvals expected within 3-5 years, potentially affecting pricing.
How does Ruxolitinib compare to other JAK inhibitors in pricing?
It is within the mid-to-high price range; competitors like Fedratinib may have similar or slightly lower prices.
What are the main markets outside the U.S.?
Europe, Japan, and Canada are significant markets, with price points generally lower due to different reimbursement policies.
Could expanded indications significantly increase market size?
Yes, especially if new autoimmune or inflammatory conditions see approval, potentially expanding the patient base substantially.
References:
[1] IQVIA. (2022). Global Pharma Market Data.
[2] FDA. (2022). Drug Approvals and Indications.
[3] EvaluatePharma. (2023). World Preview 2023.
[4] Centers for Medicare & Medicaid Services. (2023). Pharmaceutical Pricing Policies.
[5] U.S. Census Bureau. (2022). Prevalence Estimates for Hematologic Disorders.
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