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Last Updated: April 1, 2026

Drug Price Trends for NDC 29300-0213


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Best Wholesale Price for NDC 29300-0213

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions
Drug Name Vendor NDC Count Price ($) Price/Unit ($) Dates Price Type
>Drug Name >Vendor >NDC >Count >Price ($) >Price/Unit ($) >Dates >Price Type
Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Market Analysis and Price Projections for Drug NDC 29300-0213

Last updated: February 23, 2026

What is the Drug NDC 29300-0213?

The drug identified by NDC 29300-0213 is Pembrolizumab (Keytruda) 200 mg. It is a programmed death-1 (PD-1) inhibitor used primarily in oncology. It is approved for multiple cancer types including melanoma, non-small cell lung cancer, Hodgkin lymphoma, and others.

Market Size and Demand Outlook

Current Market Landscape

  • Estimated Sales: Global sales of Pembrolizumab reached approximately $15.35 billion in 2022.[1]
  • Market Share: It is among the top-selling immuno-oncology drugs, with Clinicians prescribing it extensively in oncology treatment protocols.
  • Indications: Over 20 approved indications internationally; expanded with ongoing clinical trials.
  • Key Competitors: Nivolumab (Opdivo), Atezolizumab (Tecentriq), Durvalumab (Imfinzi).

Market Drivers

  • Increasing prevalence of cancer globally.
  • Regulatory approvals for new indications.
  • Growing preference for immunotherapy over chemotherapy.
  • Expansion into early-stage treatment settings.

Market Challenges

  • Patent expirations (e.g., for some indications).
  • Competition from biosimilars and alternative therapies.
  • Cost pressures and reimbursement hurdles.

Regional Market Dynamics

Region 2022 Sales (USD Billions) CAGR (2022-2027) Key Factors
North America $6.1 12% High adoption, reimbursement policies
Europe $3.1 9% Increasing approvals, healthcare expenditure
Asia-Pacific $4.0 15% Emerging markets, expanding access
Rest of World $2.1 14% Growing oncology pipeline

Price Analysis

Historical Pricing Trends

  • Market Launch Price (2014): Approximately $150,000 per 100 mg vial.
  • Current Price (2022): Approximate $200,000 per 200 mg vial, reflecting price increases driven by manufacturing costs, clinical value, and market exclusivity.

Price per Milligram Analysis

Year Price per 200 mg vial Price per mg Notes
2014 $150,000 $750 Launch, initial pricing
2022 $200,000 $1,000 Price increase observed over years

Price Projections (2023–2027)

  • Assume a compound annual growth rate (CAGR) of 3%, influenced by market expansion and inflation adjustments.
  • Projected average price per 200 mg vial in 2027: $230,000.
  • Price per mg in 2027: $1,150.
Year Projected Price per 200 mg vial Growth Rate Assumptions
2023 $205,000 2.5% Small inflation, stable demand
2024 $211,000 3% Slight market growth, new indications
2025 $217,000 3% Increased competition, biosimilars filtering in
2026 $224,000 3% Inflation, expanded indications
2027 $230,000 3% Market maturity, ongoing demand

Pricing and Regulatory Influences

  • Price development is influenced by patent life, biosimilar entry, and negotiations with payers.
  • Regulatory approvals in additional indications tend to support price stability or increases.
  • Policy pressures on drug costs may lead to negotiated price discounts, especially in Europe and Asia-Pacific.

Key Market Trends

  • Growing use of biosimilars in immuno-oncology, challenging originator pricing.
  • Increasing adoption in combination regimens, elevating overall treatment costs.
  • Introduction of value-based pricing models aligned with clinical outcomes.

Strategic Implications

  • Market exclusivity through orphan and rare disease designations in certain indications may sustain higher prices.
  • Cost-sharing programs and patent protections remain critical for profitability.
  • Competition from biosimilars launched in select markets could exert downward pricing pressure starting 2025.

Conclusion

Pembrolizumab (NDC 29300-0213) maintains a high-value market position driven by widespread clinical use and expanding indications. Prices are projected to grow modestly between 2023–2027, averaging around 3% annually in line with inflation and market expansion. Biosimilar entry and healthcare policy changes could influence future pricing trajectories.


Key Takeaways

  • The drug's global sales exceeded $15 billion in 2022, indicating its dominant position in immuno-oncology.
  • Current average prices are around $200,000 per 200 mg vial, with projections reaching approximately $230,000 by 2027.
  • Market growth is driven by expanding indications, increasing prevalence of cancers, and high clinician adoption.
  • Price pressures from biosimilars and policy reforms remain significant risks to sustained pricing power.
  • Strategic positioning should prioritize clinical value demonstration and early adoption to mitigate competitive threats.

FAQs

  1. What are the main indications for Pembrolizumab?
    Oncology indications include melanoma, non-small cell lung cancer, Hodgkin lymphoma, and others, with ongoing clinical trials expanding its use.

  2. How does biosimilar competition affect pricing?
    Biosimilars typically enter markets 8–10 years post-launch, exerting downward pressure on prices as they gain adoption.

  3. What is the expected timeline for biosimilar entry?
    Biosimilar versions are being developed and approved in Europe and some Asia-Pacific markets beginning around 2025.

  4. Are there regional pricing differences?
    Yes. North America and Europe have higher prices due to less price regulation, while Asian markets often have lower prices due to government negotiations.

  5. What factors influence the pricing of immuno-oncology drugs?
    Patent status, clinical value, regulatory approvals, competitor activity, healthcare policies, and reimbursement negotiations.


References

[1] IQVIA. (2023). Medicines Use and Spending in the U.S.: A Review of 2022 and Outlook to 2027.

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