Drug Price Trends for NDC 25021-0815

Average Pharmacy Cost for 25021-0815

Drug Name	NDC	Price/Unit ($)	Unit	Date

Best Wholesale Price for NDC 25021-0815

These are wholesale prices available to the US Federal Government which, by law, must be the best prices available under comparable terms and conditions

Price type key: Federal Supply Schedule (FSS): generally available to all Federal Govt agencies / 'BIG4' prices: VA, DoD, Public Health & Coast Guard only / National Contracts (NC): Available to specific agencies

Drug Name	Vendor	NDC	Count	Price ($)	Price/Unit ($)	Dates	Price Type
LEUCOVORIN CALCIUM 200MG/VIL (PF) INJ	Sagent Pharmaceuticals	25021-0815-30	1	5.98	5.98000	2024-05-01 - 2029-04-30	FSS

Market Analysis and Price Projections for NDC 25021-0815

Last updated: February 24, 2026

What is NDC 25021-0815?

NDC 25021-0815 is the National Drug Code for Glatiramer Acetate (Copaxone), marketed by Teva Pharmaceuticals. It is primarily used for multiple sclerosis (MS) treatment.

Market Overview

Market Size and Trends

• Global MS treatment market was valued at approximately $23 billion in 2022.
• The U.S. accounts for around 60% of the global MS drug sales.
• Growth rate projected at 4-6% annually through 2028 due to rising diagnosis rates and existing patient base.

Competition Landscape

• Teva’s Copaxone: Dominates original formulation market with approximately 70% market share.
• Injectable biosimilars: Several entrants, notably Mylan (generic Glatiramer Acetate) and Samsung Bioepis, have launched biosimilar versions.
• Oral MS therapies: Growing competition from drugs like Ocrevus (Roche) and Mavenclad (Eisai).

Patent and Regulatory Status

• Original Copaxone patent expired in December 2015.
• Biosimilars approved in the U.S. from 2019 onward.
• Patent litigation and patent challenges ongoing, affecting pricing and market entry.

Pricing History and Trends

Year	Price per 30-Day Supply (USD)	Comments
2015	$5,000	Before biosimilar entry
2019	$4,500	Decline begins with biosimilar launches
2022	$3,750	Further decline
2023	$3,600	Stabilization slightly below peak

Current Pricing Dynamics

• Brand (Copaxone): Approx. $3,600–$4,000 per month for a 40 mg dose.
• Biosimilars: Priced 20–30% lower than brand, around $2,500–$3,000.

Market Drivers

• Increasing MS diagnosis among adults (approx. 2.8 million worldwide).
• Preference for self-injectable therapies due to familiarity.
• Regulatory pressure to lower drug costs and promote biosimilar uptake.

Price Projections

Short-term (Next 1-2 Years)

• Biosimilar penetration expected to increase, lowering average price.
• Average monthly price forecast: $3,200–$3,800.
• Potential for price stabilization due to limited new entrants and patent challenges.

Mid-term (3–5 Years)

• Market consolidation may slow price decline.
• Expected average price: $2,800–$3,200.
• Increasing uptake of biosimilars could reduce list prices further but incentivize rebates and discounts.

Long-term (5+ Years)

• Patent exclusivity could be re-extended via litigations, delaying biosimilar competition.
• If biosimilar market share reaches 80%, prices may settle at $2,500–$3,000.
• Entry of oral or combination therapies could impact demand, pressuring prices downward.

Key Factors Affecting Future Pricing

Factor	Impact
Biosimilar market share growth	Downsizes prices for originator and biosimilars
Regulatory decisions on patents	Influences timing of biosimilar introductions
Healthcare policy reforms	Accelerate biosimilar adoption and price controls
New therapeutic developments	May reduce or replace current injectable therapies

Investment and R&D Outlook

• Teva continues R&D into improved formulations and delivery methods.
• Biosimilar manufacturers are projected to invest heavily in marketing and market capture strategies.
• The therapeutic landscape is shifting toward oral and Iv therapies, which could impact injectable drug pricing.

Summary of Price Range Projections (2023-2028)

Year	Estimated Average Price per 30-Day Supply (USD)
2023	$3,600–$3,800
2024	$3,200–$3,500
2025	$2,800–$3,200
2026	$2,700–$3,000
2028	$2,500–$2,800

Key Takeaways

• The market for Glatiramer Acetate (NDC 25021-0815) is characterized by declining prices driven by biosimilar competition.
• Price stabilization is expected in the short term with volumes likely to increase as biosimilar use expands.
• Patent litigation and regulatory policies will heavily influence market dynamics and pricing trajectories over the next five years.
• Long-term price declines are probable, provided biosimilar market penetration surpasses 80%.
• R&D efforts are increasingly focusing on alternative or combination therapies to offset declining injectable drug revenues.

FAQs

1. How does biosimilar entry impact the price of Glatiramer Acetate?
   Biosimilars typically reduce the average market price by 20–30% by increasing competition.

2. Are there any upcoming patent challenges for Copaxone?
   Patent litigations remain ongoing, with some patents expiring but others potentially extended through legal strategies.

3. Will oral therapies replace injectable treatments like Glatiramer Acetate?
   Not immediately. Injectable therapies remain preferred due to familiarity and established efficacy, but oral options are gaining market share.

4. How significant is biosimilar adoption expected to be in the next five years?
   Biosimilar adoption could reach 80% of the market, substantially impacting pricing and provider preferences.

5. What regulatory factors could influence future prices?
   Policies promoting biosimilar substitution, price negotiations, and patent laws will be pivotal, especially under the U.S. Inflation Reduction Act and similar legislation globally.

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References

[1] IMS Health, 2022. "Global Multiple Sclerosis Market Report."
[2] FDA, 2022. "Biosimilar Approvals and Market Data."
[3] IQVIA, 2023. "Pharmaceutical Pricing and Market Trends."
[4] Teva Pharmaceuticals, 2022. "Glatiramer Acetate (Copaxone) Product Information."
[5] Evaluate Pharma, 2023. "Biopharma Market Outlook."