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Price type key:
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'BIG4' prices: VA, DoD, Public Health & Coast Guard only /
National Contracts (NC): Available to specific agencies
Market Analysis and Price Projections for NDC 00713-0862
Last updated: February 27, 2026
What is NDC 00713-0862?
The National Drug Code (NDC) 00713-0862 corresponds to Apixaban (brand name: Eliquis). Apixaban is an oral anticoagulant used primarily for stroke prevention in non-valvular atrial fibrillation, treatment, and secondary prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Market Size and Trends
Market Scope
Global Anticoagulant Market: Valued at USD 7.1 billion in 2022, with a projected compound annual growth rate (CAGR) of 7.8% (2022-2030).
U.S. Market Share: Apixaban holds approximately 47% of the U.S. oral anticoagulant market, regarded as the leading DOAC (direct oral anticoagulant).
Key Market Drivers
Increasing prevalence of atrial fibrillation: Estimated at 5 million in the U.S. alone.
Rising incidence of venous thromboembolism.
Evolving guidelines favoring direct oral anticoagulants over warfarin.
Advancements in drug delivery and safety profiles.
Competition Landscape
Major competitors include Dabigatran (Pradaxa), Rivaroxaban (Xarelto), and Edoxaban (Savaysa).
Prescribing trends favor factor Xa inhibitors (Apixaban, Rivaroxaban) due to lower bleeding risks.
Price Analysis
Current Pricing Landscape
Average Wholesale Price (AWP): Varies; as of Q4 2022, the median AWP for a 30-day supply (5mg twice daily) is approximately USD 455.
Average List Price (ALP): Slightly higher than AWP, in the USD 480-range.
Net Price (claimed by PBMs): Significantly lower, averaging USD 350-400 per month after rebates and discounts.
Price Trends and Projections (2023-2027)
Year
Price Range for 30-Day Supply (USD)
Notes
2023
USD 370 - USD 460
Stable, slight decrease from previous year
2024
USD 355 - USD 445
Anticipated increase in negotiations, discounts
2025
USD 340 - USD 430
Potential volume-based discounts
2026
USD 330 - USD 415
Market pressure from generics anticipated
2027
USD 315 - USD 400
Entry of biosimilars/generics likely
Impact of Biosimilars and Generics
Apixaban patents are expected to expire around 2025-2026 in the U.S.
Generic versions could reduce prices by 50% or more.
Price sensitivity will increase, especially with subsidy programs and formulary negotiations.
Regulatory and Policy Factors
FDA approval for biosimilars or generics will significantly influence pricing.
Centers for Medicare & Medicaid Services (CMS) policies, including the Inflation Reduction Act (2022), aim to lower drug costs through negotiation measures.
State Medicaid programs and private insurers could impose formulary restrictions impacting net pricing.
Market Entry and Future Outlook
Biosimilars and Generics: Likely to emerge within 2 years of patent expiry, reducing retail prices.
Market Growth: Will depend on new indications, off-label uses, and adoption rates.
Pricing Strategy: Manufacturers may retain premium pricing for branded Apixaban until generics are available, then shift focus to volume and market share acquisition.
Summary Table: Price Projections for 2023-2027
Year
Estimated Retail Price Range (USD)
Key Factors
2023
370 - 460
Stable pricing, brand dominance persists
2024
355 - 445
Negotiation intensifies, discounts increase
2025
340 - 430
Patent expiration, biosimilar entry possible
2026
330 - 415
Greater generic competition, price reductions take hold
2027
315 - 400
Market stabilizes with multiple generics available
Key Takeaways
NDC 00713-0862 (Apixaban) dominates the U.S. anticoagulant market, with rising utilization.
Prices are expected to stabilize in the short term but decline sharply post-patent expiration.
Biosimilar and generic entries will significantly press down prices starting around 2025-2026.
Payer negotiations and regulatory policies will influence net prices and market accessibility.
Manufacturers should strategize for patent cliffs by investing in pipeline drugs or expanding indications.
FAQs
When will generic apixaban enter the market?
Likely around 2025-2026, pending patent expiry and regulatory approvals.
How much will prices drop after generic entry?
Estimated reduction of 50% or more compared to current prices.
What are the main competitors of apixaban?
Rivaroxaban, dabigatran, and edoxaban.
How do regulatory policies affect pricing?
Policies like drug price negotiations and biosimilar approvals can accelerate price reductions.
What strategic moves should manufacturers consider?
Differential pricing, early biosimilar development, expanding indications, and market share expansion before patent expiration.
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