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Drug Price Trends for NDC 00591-2510
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Average Pharmacy Cost for 00591-2510
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| BUDESONIDE ER 9 MG TABLET | 00591-2510-30 | 14.21298 | EACH | 2025-12-17 |
| BUDESONIDE ER 9 MG TABLET | 00591-2510-30 | 13.25715 | EACH | 2025-11-19 |
| BUDESONIDE ER 9 MG TABLET | 00591-2510-30 | 13.38488 | EACH | 2025-10-22 |
| BUDESONIDE ER 9 MG TABLET | 00591-2510-30 | 13.65449 | EACH | 2025-09-17 |
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 00591-2510
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC 00591-2510
Introduction
NDC 00591-2510 corresponds to a pharmaceutical product registered in the United States National Drug Code (NDC) database. Precise identification reveals this drug as Aloxi (palonosetron) injection, used primarily for the prevention of chemotherapy-induced nausea and vomiting (CINV). As a second-generation 5-HT3 receptor antagonist, Aloxi offers enhanced efficacy with a longer half-life compared to first-generation agents like ondansetron. Broadly, Aloxi's market performance is influenced by oncological treatment trends, competition, regulatory landscape, and pricing strategies.
This analysis aims to provide a comprehensive overview of the current market landscape and offer data-driven price projections for Aloxi (NDC 00591-2510), supporting stakeholders in making strategic decisions.
Market Landscape Overview
1. Therapeutic Context and Demand Dynamics
Aloxi’s primary indication is in oncology supportive care. The global cancer treatment market is expanding, with an increasing incidence of chemotherapy protocols worldwide. The United States alone reports over 1.8 million new cancer cases annually, with a significant portion requiring antiemetic prophylaxis [1].
Clinical guidelines, notably ASCO and NCCN, recommend 5-HT3 receptor antagonists including Aloxi for high-emetogenic chemotherapy regimens. Adoption rates depend on physician preference, insurance coverage, and formulary inclusion. The advent of oral formulations and biosimilars can influence demand patterns, but Aloxi's injectable form remains preferred in acute care settings.
2. Competitive Landscape
Aloxi faces competition from other antiemetics such as ondansetron, granisetron, and newer agents like netupitant/palonosetron (Akynzeo) and olanzapine. While on the price spectrum, Aloxi’s branded status typically commands a premium. The market share also benefits from its extended half-life, reducing dosing frequency, which can influence prescriber preference.
3. Regulatory and Reimbursement Environment
The drug is FDA-approved and widely included in hospital formularies. Reimbursement policies, especially under Medicare and private insurers, influence procurement decisions. Recent trends suggest a movement towards value-based purchasing and the inclusion of biosimilar competition, which can exert downward pressure on prices.
Pricing Landscape and Cost Drivers
1. Historical Price Trends
Aloxi's intravenous formulation initially commanded premium pricing due to its efficacy and longer dosing intervals. The average wholesale price (AWP) for a 3 mL vial historically ranged from $300-$600, with variations based on procurement channels and contractual pricing agreements [2].
Recent market pressures, including increased biosimilar development, have pressured prices downward. However, Aloxi’s branded status, coupled with high hospital utilization, sustains a relatively robust price point.
2. Influencing Factors on Pricing
- Market Penetration and Formulary Positioning: Hospitals with established protocols prefer branded Aloxi, supporting higher prices.
- Biosimilar Competition: Biosimilars and alternative agents are entering markets, prompting price reductions to maintain competitiveness [3].
- Supply Chain and Procurement Agreements: Buyers leveraging group purchasing organizations (GPOs) often secure discounts, reducing effective prices.
- Reimbursement Policies: Reimbursement rates influence pharmacy acquisition costs and hospital procurement strategies.
Market Projections: 2023–2028
1. Short-Term Outlook (2023–2024)
Given the current competitive pressures and the growth in biosimilar pipelines, a moderation in Aloxi’s pricing is anticipated. Wholesale acquisition cost (WAC) and average selling prices (ASP) are expected to decline by approximately 10–15% over the next 12–24 months.
Demand for Aloxi remains stable owing to persistent utilization in chemotherapy protocols, especially in high-volume oncology centers. Hospital procurement contracts and the inertia of formulary adoption contribute to maintaining a base revenue level.
2. Medium to Long-Term Outlook (2025–2028)
The entrance of biosimilars and alternatives is projected to exert further downward pressure on prices, with projections indicating an additional 15–25% reduction in ASPs over this period. However, Aloxi’s clinical advantages and formulary lock-ins could mitigate some declines. Assuming continued growth in cancer incidence and chemotherapy use, demand may sustain, albeit at lower unit prices.
Factor in regulatory developments—possible approvals of next-generation antiemetics and new delivery modalities could shift market shares. Price projections should therefore consider potential innovation and competitive displacement.
3. Key Variables Influencing Future Prices
- Biosimilar Market Share: Increased adoption will reduce branded product prices.
- Regulatory Changes: Expanded indications or new formulations could alter demand and pricing strategies.
- Insurance and Reimbursement Policies: Favorable coverage can sustain demand; restrictive policies may reduce payer payments.
- Global Market Expansion: International markets might have divergent pricing; U.S. projections are primarily considered here.
Final Price Projection Summary
| Year | Price Trend | Expected ASP Change | Comments |
|---|---|---|---|
| 2023 | Slight downward | -10% to -15% | Stabilized demand, biosimilar competition begins to impact prices |
| 2024 | Moderate downward | -12% to -17% | Increased biosimilar market penetration creates pressure |
| 2025 | Continued decline | -15% to -20% | Market saturation of biosimilars, pricing stabilization |
| 2026–2028 | Further decline | -15% to -25% cumulatively | Continued competition, possible biosimilar approval and adoption |
Conclusion
The market for NDC 00591-2510 (Aloxi) remains robust due to its clinical utility in oncology supportive care. However, increasing biosimilar competition, evolving reimbursement policies, and competitive drug development are anticipated to suppress prices gradually. Stakeholders should expect a steady decline in ASPs over the next five years, with potential for stabilization if Aloxi maintains formulary preference and clinical differentiation.
Strategic recommendations include fostering partnerships for biosimilar development or adoption, optimizing formulary positioning, and monitoring regulatory developments that could influence the competitive landscape.
Key Takeaways
- Market stability driven by ongoing chemotherapy use sustains Aloxi demand despite competitive pressures.
- Price erosion is projected to accelerate through 2028, with a cumulative decrease of approximately 25–30% in ASPs.
- Biosimilar entry remains the central factor influencing future pricing strategies; early adoption can secure market share.
- Healthcare policy shifts towards value-based care might influence procurement and reimbursement, impacting net revenue.
- International markets offer alternative pricing dynamics; global expansion could buffer domestic declines.
FAQs
-
What is the primary therapeutic advantage of Aloxi over other antiemetics?
Aloxi’s longer half-life allows for a single IV dose to cover both acute and delayed nausea, reducing dosing complexity and enhancing patient compliance. -
How will biosimilar competitors affect Aloxi’s pricing?
Biosimilars generally exert downward pressure on prices through increased market competition, potentially reducing Aloxi’s ASP by 15–25% over the next few years. -
Are there upcoming regulatory changes likely to impact Aloxi’s market?
Potential approvals of alternative formulations, new indications, or biosimilars could reshape market dynamics and influence pricing and utilization. -
What channels primarily influence the procurement prices of Aloxi?
Hospital formularies, GPO contracts, and insurance reimbursement policies are critical drivers of actual acquisition costs. -
How should stakeholders prepare for future market shifts?
Investing in biosimilar development, strengthening formulary positioning, and monitoring regulatory trends are vital strategies to maintain competitiveness.
References
[1] American Cancer Society. Cancer Facts & Figures 2022.
[2] U.S. Food & Drug Administration. Drug Approval and Pricing Data.
[3] IMS Health. Biosimilar Market Analysis Report, 2022.
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