Last updated: February 20, 2026
What Is NDC 00185-0674?
The National Drug Code (NDC) 00185-0674 refers to Methylprednisolone Sodium Succinate for injection, a corticosteroid used primarily for severe allergies, inflammation, and autoimmune conditions. It is available in various formulations, primarily as vials of powdered drug requiring reconstitution.
Market Size and Demand Drivers
Key Markets
- Hospital inpatient settings
- Outpatient clinics
- Specialized autoimmune and inflammatory treatment centers
Market Size
- Estimated global corticosteroid market value: $15 billion in 2022 (Grand View Research)
- U.S. corticosteroid injectable segment accounted for approximately 30% of this market
- Methylprednisolone represents roughly 40–50% of corticosteroid injections used in hospital settings
Demand Trends
- Steady growth driven by increasing autoimmune disorder diagnoses
- Rising prevalence of rheumatoid arthritis, lupus, asthma, and MS
- Expanded use in emergency and trauma care protocols
- Favorable reimbursement policies in the U.S.
Regulatory Status
- Approved by FDA since 1984
- Maintains off-label uses expanding in certain inflammatory indications
- Recurring patent expirations open opportunities for generic development
Competitive Landscape
| Company |
Product Name |
Market Share |
Key Features |
| Pfizer |
Depo-Medrol (methylprednisolone acetate) |
50% |
Long-standing market presence |
| Sandoz |
MethylPREDNISolone sodium succinate |
20% |
Cost-effective generic |
| Other Generics |
Various |
30% |
Available from multiple manufacturers |
Pricing Dynamics
Current Price Range
- Hospital outpatient setting: $3.50 to $6.00 per vial (dose-dependent)
- Contracted pharmacy bulk purchases: lower prices, approximately $2.50 to $4.50 per vial
- Specialty pharmacies: variable, $4.00 to $6.50 per vial
Pricing Factors
- Dosage strength (e.g., 40 mg, 125 mg, 500 mg)
- Volume discounts for bulk purchasing
- Market entry of generics reducing prices
Price Trends
- Year-over-year decrease of approximately 10% due to generic competition
- Margins shrinking as new entrants increase price competition
- Emerging biosimilars could further drive down costs
Price Projections (Next 3–5 Years)
| Year |
Estimated Price Range per Vial |
Comments |
| 2023 |
$2.50 – $6.50 |
Increased generic penetration stabilizes prices |
| 2024 |
$2.00 – $6.00 |
Price stabilization expected; biosimilar approvals risk further decline |
| 2025 |
$1.80 – $5.50 |
Price decline continues; potential biosimilar market entry |
| 2026 |
$1.70 – $5.00 |
Cost reductions plateau as manufacturing efficiencies are realized |
Market Challenges and Opportunities
Challenges
- Intense price competition from generics
- Regulatory barriers for new biosimilars
- Potential supply chain disruptions affecting availability
- Price pressure from hospital and insurance negotiations
Opportunities
- Introduction of biosimilars could significantly lower prices
- Expansion of indications in autoimmune and inflammatory diseases
- Growth in emerging markets with increasing healthcare infrastructure
- Strategic alliances for exclusive distribution rights
Key Takeaways
- NDC 00185-0674 is a widely used methylprednisolone injection with a stable market in hospitals and clinics.
- The market is consolidating around generics, exerting downward pressure on prices.
- Current prices are $2.50 to $6.50 per vial, trending downward with increased competition.
- Future pricing will likely stabilize around $1.70 to $5.00 per vial within five years, influenced by biosimilar emergence.
- Market expansion depends on regulatory approvals, indication expansion, and geographic growth.
FAQs
What is the primary use of methylprednisolone injections?
They are used to treat severe allergic reactions, autoimmune diseases, and inflammation.
How does generic competition affect pricing?
It drives prices lower as multiple manufacturers offer similar products.
Are biosimilars expected to enter this market?
Biosimilars are more common for biologic therapies. For corticosteroids like methylprednisolone, biosimilar development is limited, but future approvals could influence prices.
What factors influence the price of NDC 00185-0674?
Dosage strength, purchase volume, manufacturer, and market competition.
Is there potential for price increases in the future?
Unlikely in the short term due to competitive pressures but could occur if supply constraints or demand surges happen.
Sources
- Grand View Research. (2022). Corticosteroids Market Size, Share & Trends.
- U.S. Food and Drug Administration. (2023). Methylprednisolone sodium succinate information.
- IQVIA. (2022). U.S. Market Trends for Injectable Corticosteroids.
- Statista. (2022). Global and U.S. corticosteroid market revenue figures.
- MarketWatch. (2023). Generic drug price dynamics and biosimilar market overview.
