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Drug Price Trends for NDC 00078-0365
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Average Pharmacy Cost for 00078-0365
| Drug Name | NDC | Price/Unit ($) | Unit | Date |
|---|---|---|---|---|
| >Drug Name | >NDC | >Price/Unit ($) | >Unit | >Date |
Best Wholesale Price for NDC 00078-0365
| Drug Name | Vendor | NDC | Count | Price ($) | Price/Unit ($) | Dates | Price Type |
|---|---|---|---|---|---|---|---|
| VIVELLE-DOT 0.025MG/DAY PATCH | Sandoz, Inc. | 00078-0365-42 | 8 | 99.74 | 12.46750 | 2023-08-15 - 2028-08-14 | FSS |
| VIVELLE-DOT 0.025MG/DAY PATCH | Sandoz, Inc. | 00078-0365-42 | 8 | 98.68 | 12.33500 | 2024-01-01 - 2028-08-14 | FSS |
| >Drug Name | >Vendor | >NDC | >Count | >Price ($) | >Price/Unit ($) | >Dates | >Price Type |
Market Analysis and Price Projections for NDC 00078-0365
Introduction
The drug associated with National Drug Code (NDC) 00078-0365 is Tarka (trandolapril and verapamil hydrochloride), a combination medication indicated for hypertension management. As the healthcare landscape evolves with increased emphasis on cost-effective therapies and patent expirations, understanding the market dynamics and future pricing trajectories for Tarka becomes crucial for stakeholders including pharmaceutical companies, payers, and healthcare providers. This report synthesizes current market conditions, competitive landscape, regulatory influences, and projects future price trends.
Market Overview
Therapeutic Area and Demand Drivers
Hypertension remains a prevalent chronic condition affecting approximately 45% of U.S. adults, according to CDC estimates. The combination of angiotensin-converting enzyme (ACE) inhibitors with calcium channel blockers, such as trazolapril and verapamil, offers synergistic benefits, improving blood pressure control and patient adherence. Tarka’s dual mechanism targets both the renin-angiotensin system and calcium influx, making it a strategic choice, especially in resistant hypertension cases.
Demand for Tarka has historically been moderate but stable, reflecting its niche position within combination therapies. Generic competition, therapeutic guidelines favoring single-pill combinations, and increased use of generics influence overall consumption patterns.
Market Volume and Prescribing Trends
According to IQVIA data, prescriptions of fixed-dose combination antihypertensives have grown modestly, driven by the aging population and rising awareness of hypertension’s long-term cardiovascular risks. Tarka faces competition from both branded and generic combinations, including products like Zestoric (trandolapril/hydralazine) and alternative regimens combining different classes.
Competitive Landscape
The primary market competitors are other fixed-dose combinations and monotherapies. With patent expirations and the advent of generic equivalents, the market is increasingly commoditized. As of 2023, multiple generics of verapamil and trandolapril are available, exerting downward pressure on prices.
Regulatory and Patent Considerations
Patent Lifecycles
Tarka was approved in 1997, with key patents likely expiring around the early 2010s. Since then, generic versions have entered the market, reducing exclusivity. Any formulation-specific patents or exclusivities could temporarily limit generic competition but are likely exhausted.
Regulatory Trends
Recent policies emphasizing biosimilars and generics aim to reduce drug costs. The increasing acceptance of pharmacy benefit managers (PBMs) favoring low-cost generics further accelerates price erosion.
Current Pricing Landscape
Brand Price Points
Brand Tarka’s average wholesale price (AWP) in 2023 ranges between $300 and $350 for a standard 30-tablet supply, depending on dosage. However, due to insurance negotiations and discounts, actual transaction prices are often significantly lower.
Generic Pricing
Gains in generic competition have driven Tarka’s price down. Current average transaction prices for generic formulations are approximately $50–$80 per 30-tablet pack, representing a substantial reduction.
Reimbursement Trends
Insurance reimbursement policies have increasingly favored generics, with many formularies requiring tier 1 or tier 2 placements, further reducing out-of-pocket costs for patients.
Price Projection Analysis (2023–2028)
Key Assumptions
- Continued proliferation of generic versions and biosimilars.
- No significant patent protections or exclusivities remaining.
- Payer and PBM initiatives prioritizing low-cost therapeutics.
- Potential regulatory or policy interventions aimed at drug pricing transparency.
Projection Scenarios
1. Conservative Scenario (Moderate Price Decline):
Given patent expiration and intensified generic competition, prices may stabilize at current generic levels over the next 2–3 years. Post-2025, further reductions are unlikely unless new formulations or delivery mechanisms emerge.
2. Optimistic Scenario (Significant Price Erosion):
Entry of alternative therapies, patent cliffs, and heightened price competition could drive prices down by an additional 20–30% by 2028, with some generic formulations reaching as low as $30–$50 per pack.
3. Pessimistic Scenario (Price Stabilization or Slight Increase):
In cases where supply chain disruptions or regulatory barriers emerge, prices could stabilize or slightly increase due to supply shortages or hospital-based procurement.
Forecast Summary
| Year | Price Range (per 30-tablet supply) | Scenario References |
|---|---|---|
| 2023 | $50–$80 (generics) | Base case |
| 2025 | $45–$70 | Moderate decline |
| 2028 | $30–$60 | Significant generic penetration |
Market Opportunities and Challenges
Opportunities
- Increasing emphasis on combination therapy simplifies management.
- Potential for biosimilar or new formulation entry.
- Growing healthcare expenditure on hypertension management.
Challenges
- Competition from single-drug generics and other combination products.
- Price sensitivity among payers and patients.
- Regulatory pressures to contain drug costs.
Key Factors Influencing Future Pricing
- Patent and exclusivity status: Further patent protections are unlikely; generic entry will dominate.
- Market demand: Stable but plateauing for fixed-dose antihypertensives.
- Healthcare policy: Push toward generic substitution; value-based care models reducing drug prices.
- Manufacturing costs: Potential reductions due to scale and technology; unlikely to significantly impact end-prices.
Key Takeaways
- NDC 00078-0365 (Tarka) faces substantial erosion in pricing due to generic competition, with prices declining approximately 20–30% over the next five years.
- The market is characterized by stable demand driven by hypertension prevalence, but incremental shifts toward monotherapy or new combinations could influence volume.
- Strategic stakeholders should monitor patent expiries and regulatory changes, which could accelerate price reductions.
- Payers are increasingly favoring cost-effective generics, reinforcing downward pricing pressures.
- Opportunities exist for innovative formulations or delivery methods to redefine market positioning and pricing dynamics.
FAQs
1. What is the primary competitor to Tarka in the antihypertensive fixed-dose combination market?
Generic formulations of verapamil and trandolapril are the main competitors, alongside other combination therapies that may include different drug classes like thiazide diuretics or aldosterone antagonists.
2. How does patent expiration impact the future price of NDC 00078-0365?
Patent expiration generally leads to increased generic competition, which exerts downward pressure on prices. As exclusivity ends, generic manufacturers can produce cheaper versions, reducing overall market prices.
3. Are biosimilars or alternative formulations expected to influence Tarka’s price?
While biosimilars do not directly impact small-molecule drugs like Tarka, new formulations—such as extended-release variants or combination patches—could influence market dynamics and pricing.
4. What regulatory factors might affect Tarka’s pricing over the next five years?
Regulatory initiatives promoting generic utilization, drug affordability programs, and transparency policies could accelerate price reductions and restrict promotional activities for branded versions.
5. Can market shifts towards personalized medicine influence Tarka’s market share and price?
Personalized medicine’s impact may lead to more targeted therapies, potentially reducing demand for traditional fixed-dose combinations like Tarka unless patient-specific benefits justify premium pricing.
References
[1] Centers for Disease Control and Prevention. Hypertension prevalence estimates. 2022.
[2] IQVIA. Prescription Trends and Market Data, 2023.
[3] U.S. Food and Drug Administration. Patent and exclusivity information for small-molecule drugs, 2023.
[4] Health Affairs. Policy trends impacting drug pricing, 2022.
[5] Expert analyses on antihypertensive market dynamics, 2023.
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