Drug Price Trends for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE

Average Pharmacy Cost for SPIRONOLACTONE-HYDROCHLOROTHIAZIDE

These are average pharmacy acquisition costs (net of discounts) from a US national survey

Drug Name	NDC	Price/Unit ($)	Unit	Date
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB	00378-0403-05	0.57394	EACH	2025-03-19
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB	42292-0017-01	0.57394	EACH	2025-03-19
SPIRONOLACTONE-HYDROCHLOROTHIAZIDE 25-25 TAB	00378-0403-01	0.57394	EACH	2025-03-19

Market Analysis and Price Projections for Spironolactone-Hydrochlorothiazide

Introduction to Spironolactone-Hydrochlorothiazide

Spironolactone-hydrochlorothiazide, a combination of a potassium-sparing diuretic (spironolactone) and a thiazide diuretic (hydrochlorothiazide), is widely used for treating conditions such as ascites, edema, heart failure, and hypertension. This medication is part of the potassium sparing diuretics with thiazides drug class[1][2].

Market Dynamics

Market Drivers

The market for spironolactone-hydrochlorothiazide is driven by several key factors:

• Increasing Prevalence of Cardiovascular Diseases: The rising number of patients suffering from hypertension and heart failure globally is a significant driver for this market. As the population ages and the incidence of cardiovascular diseases increases, the demand for effective diuretics like spironolactone-hydrochlorothiazide is expected to grow[4].
• Expanded Use in Dermatology: The use of spironolactone in treating acne, hirsutism, and other hormonal conditions has expanded its market beyond traditional cardiovascular applications. This broader therapeutic use enhances market growth[3].
• Improvement in Healthcare Infrastructure: Advances in healthcare infrastructure in emerging markets have made spironolactone-hydrochlorothiazide more accessible, contributing to market expansion[3].

Market Restraints

Despite the growth drivers, there are several restraints that impact the market:

• Price Sensitivity and Generic Competition: The availability of generic versions of spironolactone-hydrochlorothiazide and the sensitivity to pricing pressures can reduce the market share and profitability of branded drugs. Generic competition often leads to lower prices, which can be challenging for branded pharmaceuticals to maintain profit margins[2][3].
• Side Effects and Limited Awareness: Potential side effects associated with spironolactone-hydrochlorothiazide, such as those related to long-term use in off-label applications, can lead to patient reluctance. Additionally, limited awareness among healthcare professionals about newer indications can restrict widespread utilization[3][4].

Price Analysis

Current Pricing

The cost of spironolactone-hydrochlorothiazide varies based on the dosage and the pharmacy.

• Generic Version: For a generic version of spironolactone-hydrochlorothiazide (25 mg-25 mg), the cost can be as low as $0.57 per tablet for a supply of 30 tablets, translating to around $23 for 30 tablets[5].
• Branded Version (Aldactazide): The branded version, Aldactazide (50 mg-50 mg), is significantly more expensive, with a cost of around $539 for a supply of 100 tablets[2].

Price Projections

Given the market dynamics, here are some price projection insights:

• Generic Pricing Stability: The prices of generic spironolactone-hydrochlorothiazide are expected to remain relatively stable due to intense competition among generic manufacturers. However, prices may fluctuate slightly based on supply and demand[5].
• Branded Pricing Pressure: Branded versions like Aldactazide are likely to face continued pricing pressure due to generic competition and the availability of more affordable alternatives. This could lead to a slight decrease in prices over time[2].

Impact of Market Trends

• Telemedicine and E-Health Solutions: The integration of telemedicine and e-health solutions could enhance patient adherence and accessibility, potentially stabilizing or slightly increasing prices due to increased demand and convenience[3].
• New Indications and Combination Therapies: Research into new indications and the development of combination therapies using spironolactone could unlock new market potential, which might influence pricing strategies to balance innovation with affordability[3].

Patient Assistance and Copay Programs

For patients who find the medication costly, there are several patient assistance and copay programs available:

• Discount Cards: Programs like the Drugs.com discount card can save patients up to 80% on prescription medicines, including spironolactone-hydrochlorothiazide[1].
• Patient Access Network Foundation (PAN): This foundation provides assistance to patients with health insurance, covering the qualifying medication for which they seek assistance. Eligibility criteria include residing in the U.S. and having a specific FDA-approved diagnosis[2].

Market Opportunities

• Emerging Markets: Expanding into emerging markets where healthcare infrastructure is improving can provide significant growth opportunities for spironolactone-hydrochlorothiazide[3].
• Consumer Education: Campaigns to educate consumers about the diverse applications of spironolactone-hydrochlorothiazide can boost awareness and drive market growth[3].
• Combination Therapies: Developing combination drugs that include spironolactone can enhance therapeutic effects and open up new market segments[3].

Market Challenges

• Side Effects and Safety Concerns: Addressing potential side effects and ensuring long-term safety, especially in off-label applications, is crucial for maintaining market confidence[3].
• Environmental and Economic Impacts: The market must be prepared to mitigate unforeseen environmental and economic impacts that could affect supply chains and pricing[3].

Key Takeaways

• The market for spironolactone-hydrochlorothiazide is driven by increasing cardiovascular disease prevalence, expanded use in dermatology, and improvements in healthcare infrastructure.
• Generic competition and price sensitivity are significant restraints.
• Prices are expected to remain stable for generics but may face pressure for branded versions.
• Patient assistance programs and discount cards can help make the medication more affordable.
• Emerging markets, consumer education, and combination therapies offer growth opportunities.

FAQs

What is spironolactone-hydrochlorothiazide used for?

Spironolactone-hydrochlorothiazide is used to treat conditions such as ascites, edema, heart failure, and hypertension. It is also used in dermatology for treating acne and hormonal conditions.

How much does spironolactone-hydrochlorothiazide cost?

The cost of spironolactone-hydrochlorothiazide can vary. For a generic version (25 mg-25 mg), it can cost around $23 for 30 tablets. The branded version, Aldactazide (50 mg-50 mg), costs around $539 for 100 tablets.

Are there any patient assistance programs available for spironolactone-hydrochlorothiazide?

Yes, there are patient assistance programs such as the Drugs.com discount card and programs from the Patient Access Network Foundation (PAN) that can help make the medication more affordable.

What are the potential side effects of spironolactone-hydrochlorothiazide?

Potential side effects include those related to long-term use, especially in off-label applications. Common side effects can be found in the medication's drug information section.

How is the market for spironolactone-hydrochlorothiazide expected to grow?

The market is expected to grow due to increasing prevalence of cardiovascular diseases, expanded use in dermatology, and improvements in healthcare infrastructure. However, it faces challenges from generic competition and price sensitivity.

Sources

1. Drugs.com: Hydrochlorothiazide/spironolactone Prices, Coupons, Copay Cards & Patient Assistance.
2. Drugs.com: Aldactazide Prices, Coupons, Copay Cards & Patient Assistance.
3. 360iResearch: Spironolactone Drugs Market Size & Share 2025-2030.
4. Allied Market Research: Hydrochlorothiazide Market Size | Industry Growth, (2021-2030).
5. PharmacyChecker: Spironolactone-Hctz Prices - U.S. & International.