Drug Price Trends for SM ALLERGY (DIPHEN)

Average Pharmacy Cost for SM ALLERGY (DIPHEN)

These are average pharmacy acquisition costs (net of discounts) from a US national survey

Drug Name	NDC	Price/Unit ($)	Unit	Date
SM ALLERGY (DIPHEN) 25 MG CAP	70677-0002-02	0.04424	EACH	2025-02-19
SM ALLERGY (DIPHEN) 25 MG TAB	70677-0003-01	0.03510	EACH	2025-02-19
SM ALLERGY (DIPHEN) 25 MG CAP	70677-0002-02	0.04248	EACH	2025-01-22
SM ALLERGY (DIPHEN) 25 MG TAB	70677-0003-01	0.03643	EACH	2025-01-22
SM ALLERGY (DIPHEN) 25 MG CAP	70677-0002-02	0.04118	EACH	2024-12-18
SM ALLERGY (DIPHEN) 25 MG CAP	70677-0002-02	0.04186	EACH	2024-11-20
SM ALLERGY (DIPHEN) 25 MG CAP	70677-0002-02	0.04169	EACH	2024-10-23

Diphenhydramine Market Analysis and Price Projections

Introduction to Diphenhydramine

Diphenhydramine, commonly known by its brand name Benadryl, is an antihistamine medication widely used to relieve symptoms of allergies, hay fever, the common cold, motion sickness, and insomnia. Its broad applications and ease of access as an over-the-counter (OTC) medication make it a staple in many households.

Market Size and Growth Projections

The diphenhydramine market is anticipated to experience steady growth over the coming years. Here are some key projections:

• Current Market Size: As of 2024, the diphenhydramine market size is estimated at USD 0.99 billion[1][4].
• Future Projections: The market is expected to reach USD 1.10 billion by 2029, growing at a Compound Annual Growth Rate (CAGR) of 2.30% during the forecast period (2025-2030)[1][4].
• Long-term Outlook: By 2030, the market size is projected to be USD 1.13 billion, maintaining a CAGR of 2.3% from 2025 to 2030[1][4].

Drivers of Market Growth

Several factors are driving the growth of the diphenhydramine market:

Increasing Prevalence of Allergies

The rising number of people suffering from seasonal allergies and allergic rhinitis is a significant driver. For instance, approximately 25.7% of US adults reported experiencing seasonal allergies in 2022, and about 50% of Europe's population is expected to suffer from some type of allergy sensitivity by 2025 due to climate change[1][4].

Growing Demand for OTC Medications

The increasing awareness and preference for self-medication and OTC remedies are boosting the demand for diphenhydramine. Consumers are becoming more proactive in managing their health, leading to a higher demand for convenient and cost-effective medications like diphenhydramine[3].

Motion Sickness and Insomnia

The growing prevalence of motion sickness among international travelers and the increasing awareness about sleep disorders are also driving the market. For example, an estimated 66.5 million tourists traveled internationally in the United States in 2023, a 31% increase from 2022, which increases the demand for motion sickness medications[1][4].

Technological Advancements

Technological advancements in drug delivery systems are expanding the application spectrum of diphenhydramine. Novel formulations are being developed to enhance the efficacy and duration of action of diphenhydramine-based products[3].

Regional Market Analysis

North America

North America is anticipated to hold a significant share of the market due to the increasing number of allergic individuals and growing government initiatives. For instance, around 25 metropolitan areas in the US are under the high-risk category for allergy attacks[1][4].

Asia-Pacific

The Asia-Pacific region is expected to be the fastest-growing market, driven by increasing healthcare awareness and the rising prevalence of allergies and other conditions that diphenhydramine treats[1].

Price Projections

Current Trends

Diphenhydramine hydrochloride prices are expected to rise moderately in the short term. This increase is attributed to steady demand from the pharmaceutical and healthcare sectors, coupled with constrained supply from market players. Seasonal changes, such as the onset of allergy season, further drive this trend[2].

Supply Chain Factors

The upcoming Mid-Autumn Festival in China and the Golden Week holiday are expected to influence market dynamics by causing production slowdowns, distribution interruptions, and supply chain disruptions. These factors are likely to put upward pressure on diphenhydramine hydrochloride prices[2].

Economic Factors

Consumer sentiment and economic conditions also play a role. For instance, the increase in consumer confidence in the US and potential monetary easing in Europe could support rising diphenhydramine hydrochloride prices[2].

Challenges and Restraints

Side Effects

Despite the market's growth prospects, the side effects associated with long-term use of diphenhydramine are likely to hinder market growth. These side effects include drowsiness, dry mouth, and constipation, among others[1][3][4].

Availability of Alternative Medications

The presence of alternative medications is another restraint. As new antihistamines and other treatments become available, they may compete with diphenhydramine for market share[3].

Segment Analysis

Application Segments

The market is segmented based on various applications, including allergies, insomnia, cold symptoms, and motion sickness. Allergies are expected to remain a significant segment, driven by the rising incidence of allergic reactions triggered by environmental factors, food, and medications[3].

Dosage Forms

The market will likely experience notable expansion across different dosage forms, including tablets, injections, powders, and syrups. These diverse options cater to different patient preferences and medical needs[3].

Key Takeaways

• The diphenhydramine market is projected to grow from USD 0.99 billion in 2024 to USD 1.10 billion by 2029.
• The increasing prevalence of allergies, motion sickness, and insomnia are key drivers of market growth.
• North America and the Asia-Pacific region are significant markets, with North America holding a major share and the Asia-Pacific region expected to be the fastest-growing.
• Price increases are anticipated due to steady demand and constrained supply, influenced by seasonal changes and economic factors.
• Side effects and the availability of alternative medications are potential restraints on market growth.

FAQs

What is the current market size of the diphenhydramine market?

The current market size of the diphenhydramine market is estimated at USD 0.99 billion as of 2024[1][4].

What is the projected growth rate of the diphenhydramine market?

The diphenhydramine market is expected to grow at a CAGR of 2.30% from 2025 to 2030[1][4].

Which region is expected to be the fastest-growing market for diphenhydramine?

The Asia-Pacific region is expected to be the fastest-growing market for diphenhydramine[1].

What are the main drivers of the diphenhydramine market growth?

The main drivers include the increasing prevalence of allergies, growing demand for OTC medications, motion sickness, and insomnia, as well as technological advancements in drug delivery systems[1][3][4].

What are the potential restraints on the diphenhydramine market?

The potential restraints include side effects associated with long-term use and the availability of alternative medications[1][3][4].

Sources

1. Mordor Intelligence: Diphenhydramine Market Size & Share Analysis.
2. ChemAnalyst: Allergy Season Squeeze: Diphenhydramine Hydrochloride Prices Set to Soar in September.
3. Reanin: Global Diphenhydramine Market | Growth | Share | Size | Trends and Forecast.
4. Mordor Intelligence: Diphenhydramine Market Size (2024 - 2029).