Drug Price Trends for ETHYNODIOL-ETH ESTRA

Average Pharmacy Cost for ETHYNODIOL-ETH ESTRA

These are average pharmacy acquisition costs (net of discounts) from a US national survey

Drug Name	NDC	Price/Unit ($)	Unit	Date
ETHYNODIOL-ETH ESTRA 1 MG-35 MCG	00378-7307-53	0.36246	EACH	2025-03-19
ETHYNODIOL-ETH ESTRA 1 MG-35 MCG	00378-7307-85	0.36246	EACH	2025-03-19
ETHYNODIOL-ETH ESTRA 1 MG-50 MCG	00378-7306-85	0.49538	EACH	2025-03-19
ETHYNODIOL-ETH ESTRA 1 MG-50 MCG	00378-7306-53	0.49538	EACH	2025-03-19

Market Analysis and Price Projections for Ethynodiol Diacetate and Ethinyl Estradiol

Introduction

Ethynodiol diacetate and ethinyl estradiol are components of combined oral contraceptives (COCs) widely used for preventing pregnancy and managing various menstrual and hormonal conditions. This analysis will delve into the market dynamics, pricing trends, and projections for these medications.

Market Overview

The market for combined oral contraceptives is robust and driven by the high demand for effective and convenient birth control methods. Ethynodiol diacetate and ethinyl estradiol are key ingredients in several COC formulations, including brand names like Vienva, Aviane, Lutera, and Kurvelo[2].

Indications and Usage

These medications are primarily indicated for the prevention of pregnancy but are also used to treat conditions such as moderate acne, premenstrual dysphoric disorder, and moderate to severe vasomotor symptoms of menopause. The combination of ethynodiol diacetate and ethinyl estradiol works by suppressing gonadotropins, thickening cervical mucus, and altering the endometrium to prevent implantation of a fertilized egg[3].

Pricing Trends

The pricing of ethynodiol diacetate and ethinyl estradiol combination tablets varies based on the formulation, dosage, and brand.

• Extended Cycle Formulations: Prices for extended cycle formulations can range from approximately $134 for a supply of 273 tablets (30 mcg-0.15 mg) to $189 for a supply of 91 tablets (quadriphasic extended cycle)[2].
• Biphasic and Triphasic Formulations: Biphasic and triphasic formulations can cost between $35 and $311 for a supply of 84 to 182 tablets, depending on the specific dosage and cycle[2].

Factors Influencing Pricing

Several factors influence the pricing of these medications:

• Generic vs. Brand Name: Generic versions are generally cheaper than brand name versions. The cost difference can be significant, with generic options often being 20-50% less expensive[5].
• Pharmacy and Location: Prices can vary significantly depending on the pharmacy and location. The use of discount cards or patient assistance programs can also impact the final cost[2].
• Dosage and Formulation: Different dosages and formulations (e.g., biphasic, triphasic, extended cycle) have varying price points[2].

Market Competition

The market for COCs is competitive, with multiple brands and generic options available. This competition helps keep prices in check, although brand loyalty and marketing efforts can influence consumer choices.

Regulatory and Health Considerations

Regulatory factors, such as FDA approvals and contraindications, also play a role in the market dynamics. For instance, ethynodiol diacetate and ethinyl estradiol are contraindicated in females with current or past breast cancer, which can affect market demand[3].

Price Projections

Given the stable demand for COCs and the competitive market, here are some price projection considerations:

• Short-Term Projections: Prices are likely to remain relatively stable in the short term, with minor fluctuations based on supply chain and pharmacy pricing strategies.
• Long-Term Projections: As generic versions become more prevalent and competition increases, prices may trend downward. However, the introduction of new formulations or brand name products could maintain or slightly increase prices.
• Impact of Generic Substitution: State drug product selection laws and the increasing acceptance of generic substitutions are expected to drive prices down as more patients opt for generic versions[5].

Key Takeaways

• Stable Demand: The demand for COCs is consistent, driven by their effectiveness and convenience.
• Pricing Variability: Prices vary based on formulation, dosage, and brand, with generic options generally being cheaper.
• Regulatory Factors: Contraindications and regulatory approvals influence market dynamics.
• Competition: A competitive market with multiple brands and generic options helps keep prices in check.

FAQs

Q: What are the primary indications for ethynodiol diacetate and ethinyl estradiol? A: These medications are primarily indicated for the prevention of pregnancy but are also used to treat conditions such as moderate acne, premenstrual dysphoric disorder, and moderate to severe vasomotor symptoms of menopause.

Q: How do ethynodiol diacetate and ethinyl estradiol work? A: They work by suppressing gonadotropins, thickening cervical mucus, and altering the endometrium to prevent implantation of a fertilized egg.

Q: What are the common brand names for these medications? A: Common brand names include Vienva, Aviane, Lutera, and Kurvelo.

Q: How do prices vary for different formulations? A: Prices vary significantly based on the formulation, dosage, and brand, with extended cycle formulations generally costing more than biphasic or triphasic formulations.

Q: What factors influence the pricing of these medications? A: Factors include generic vs. brand name, pharmacy and location, dosage and formulation, and regulatory considerations.

Sources

1. DrugBank: Ethinylestradiol: Uses, Interactions, Mechanism of Action.
2. Drugs.com: Ethinyl estradiol/levonorgestrel Prices, Coupons, Copay Cards & Patient Assistance.
3. DailyMed: Ethynodiol Diacetate and Ethinyl Estradiol Tablets USP, 1 mg/35 mcg.
4. DrugBank: Ethynodiol diacetate: Uses, Interactions, Mechanism of Action.
5. Federal Trade Commission: Economic Effects of State Drug Product Selection Laws.