Radiation Therapy With or Without Antiandrogen Therapy in Treating Patients With Stage I or Stage II Prostate Cancer
Completed
National Cancer Institute (NCI)
Phase 3
1994-10-01
RATIONALE: Radiation therapy (RT) uses high-energy x-rays to damage tumor cells. Androgens
can stimulate the growth of prostate cancer cells. Hormone therapy using flutamide,
goserelin, and leuprolide may fight prostate cancer by reducing the production of androgens.
It is not yet known which regimen of antiandrogen therapy is most effective for prostate
cancer.
PURPOSE: Randomized phase III trial to study the effectiveness of radiation therapy with or
without antiandrogen therapy in treating patients who have stage I or stage II prostate
cancer.
Radiation Therapy With or Without Antiandrogen Therapy in Treating Patients With Stage I or Stage II Prostate Cancer
Completed
Radiation Therapy Oncology Group
Phase 3
1994-10-01
RATIONALE: Radiation therapy (RT) uses high-energy x-rays to damage tumor cells. Androgens
can stimulate the growth of prostate cancer cells. Hormone therapy using flutamide,
goserelin, and leuprolide may fight prostate cancer by reducing the production of androgens.
It is not yet known which regimen of antiandrogen therapy is most effective for prostate
cancer.
PURPOSE: Randomized phase III trial to study the effectiveness of radiation therapy with or
without antiandrogen therapy in treating patients who have stage I or stage II prostate
cancer.
Randomized Trial of Adjuvant Hormonal Therapy in Surgically Treated Prostate Cancer Patients at High Risk for Recurrence
Terminated
AstraZeneca
Phase 3
1999-06-14
RATIONALE: Testosterone can stimulate the growth of prostate cancer cells. Hormone therapy
using leuprolide and flutamide may fight prostate cancer by reducing the production of
testosterone. It is not yet known whether receiving leuprolide and flutamide is more
effective than receiving no further therapy.
PURPOSE: Randomized phase III trial to determine the effectiveness of hormone therapy in
treating patients who have stage I or stage II prostate cancer that is at high risk of
recurrence and who have already undergone surgery.
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