CLINICAL TRIALS PROFILE FOR ZINC ACETATE

505(b)(2) Clinical Trials for Zinc Acetate

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials

Trial Type	Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
OTC	NCT00169299 ↗	Herbal Alternatives for Menopause Symptoms (HALT Study)	Unknown status	National Center for Complementary and Integrative Health (NCCIH)	Phase 4	2001-06-01	Surveys indicate that 25 to 33% of women have moderate to severe menopausal symptoms including hot flashes, night sweats, and disturbed sleep. The treatment of choice in the medical community for these symptoms is hormone replacement therapy, which is estrogen and sometimes progestin. Many women also use over-the-counter herbal remedies. However, less is known about how well these products work, or their safety. Few have undergone the kind of rigorous testing required of prescription drugs and little is known about their long-term effectiveness in relieving symptoms. The purpose of this study is to compare several over-the-counter herbal remedies to hormone replacement therapy. Our primary aim is to look at the effects of these remedies on your self-reported menopausal symptoms. We will also be measuring their effects on other factors known to be affected by hormone replacement therapy: cholesterol, blood sugar, bone density, vaginal cell structure, and blood clotting.
OTC	NCT00169299 ↗	Herbal Alternatives for Menopause Symptoms (HALT Study)	Unknown status	National Institute on Aging (NIA)	Phase 4	2001-06-01	Surveys indicate that 25 to 33% of women have moderate to severe menopausal symptoms including hot flashes, night sweats, and disturbed sleep. The treatment of choice in the medical community for these symptoms is hormone replacement therapy, which is estrogen and sometimes progestin. Many women also use over-the-counter herbal remedies. However, less is known about how well these products work, or their safety. Few have undergone the kind of rigorous testing required of prescription drugs and little is known about their long-term effectiveness in relieving symptoms. The purpose of this study is to compare several over-the-counter herbal remedies to hormone replacement therapy. Our primary aim is to look at the effects of these remedies on your self-reported menopausal symptoms. We will also be measuring their effects on other factors known to be affected by hormone replacement therapy: cholesterol, blood sugar, bone density, vaginal cell structure, and blood clotting.
OTC	NCT00169299 ↗	Herbal Alternatives for Menopause Symptoms (HALT Study)	Unknown status	Group Health Cooperative	Phase 4	2001-06-01	Surveys indicate that 25 to 33% of women have moderate to severe menopausal symptoms including hot flashes, night sweats, and disturbed sleep. The treatment of choice in the medical community for these symptoms is hormone replacement therapy, which is estrogen and sometimes progestin. Many women also use over-the-counter herbal remedies. However, less is known about how well these products work, or their safety. Few have undergone the kind of rigorous testing required of prescription drugs and little is known about their long-term effectiveness in relieving symptoms. The purpose of this study is to compare several over-the-counter herbal remedies to hormone replacement therapy. Our primary aim is to look at the effects of these remedies on your self-reported menopausal symptoms. We will also be measuring their effects on other factors known to be affected by hormone replacement therapy: cholesterol, blood sugar, bone density, vaginal cell structure, and blood clotting.

All Clinical Trials for Zinc Acetate

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00000466 ↗	Postmenopausal Estrogen/Progestin Interventions (PEPI)	Completed	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Phase 3	1987-09-01	To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 ↗	Postmenopausal Estrogen/Progestin Interventions (PEPI)	Completed	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	Phase 3	1987-09-01	To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.
NCT00000466 ↗	Postmenopausal Estrogen/Progestin Interventions (PEPI)	Completed	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Phase 3	1987-09-01	To assess the effects of various postmenopausal estrogen replacement therapies on selected cardiovascular risk factors, including high density lipoprotein cholesterol, systolic blood pressure, fibrinogen, and insulin and on osteoporosis risk factors. Conducted in collaboration with the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, The National Institute of Diabetes and Digestive and Kidney Diseases, and the National Institute on Aging. The extended follow-up is for 3 years focusing on endometrium and breast evaluation.

Clinical Trial Conditions for Zinc Acetate

Condition Name

Condition Name for Zinc Acetate
Intervention	Trials
Prostate Cancer	148
Contraception	52
Endometriosis	39

Condition MeSH

Condition MeSH for Zinc Acetate
Intervention	Trials
Prostatic Neoplasms	295
Sclerosis	68
Multiple Sclerosis	65

Clinical Trial Locations for Zinc Acetate

Trials by Country

Trials by Country for Zinc Acetate
Location	Trials
Canada	336
Spain	143
United Kingdom	139
Germany	130
France	121

Trials by US State

Trials by US State for Zinc Acetate
Location	Trials
California	242
New York	220
Texas	206
Florida	186
North Carolina	163

Clinical Trial Progress for Zinc Acetate

Clinical Trial Phase

Clinical Trial Phase for Zinc Acetate
Clinical Trial Phase	Trials
Phase 4	208
Phase 3	294
Phase 2/Phase 3	46

Clinical Trial Status

Clinical Trial Status for Zinc Acetate
Clinical Trial Phase	Trials
Completed	699
Recruiting	189
Terminated	113

Clinical Trial Sponsors for Zinc Acetate

Sponsor Name

Sponsor Name for Zinc Acetate
Sponsor	Trials
National Cancer Institute (NCI)	112
Janssen Research & Development, LLC	38
Bial - Portela C S.A.	38

Sponsor Type

Sponsor Type for Zinc Acetate
Sponsor	Trials
Other	1170
Industry	780
NIH	189

Zinc Acetate: Clinical Trials, Market Analysis, and Projections

Introduction to Zinc Acetate

Zinc acetate is a compound consisting of zinc and acetic acid, widely used in various industrial, laboratory, and pharmaceutical applications. Its versatility and therapeutic properties make it a valuable ingredient in multiple sectors.

Clinical Trials Involving Zinc Acetate

Feasibility and Safety in GNAO1 Associated Disorders

A prospective pilot trial is currently underway to investigate the feasibility and safety of oral zinc therapy in patients with Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1) associated disorders. This trial involves administering oral zinc to participants for six months, with assessments conducted through three visits and two phone calls. The primary goal is to evaluate the safety and efficacy of zinc therapy in this specific patient group[1].

Effectiveness in Treating Common Colds

Two clinical trials have been conducted to assess the effectiveness of zinc acetate and zinc gluconate in treating common colds. These trials involved subjects with experimental rhinovirus colds and natural colds. The results showed that zinc gluconate reduced the median duration of illness in experimental colds but had no effect on symptom severity or the duration and severity of natural cold symptoms. Zinc acetate did not show any significant effects on either duration or severity of cold symptoms[4].

Market Analysis of Zinc Acetate

Global Market Size and Growth

The global zinc acetate market is experiencing significant growth. As of 2023, the market size was valued at USD 189.83 million and is expected to expand at a Compound Annual Growth Rate (CAGR) of 5.3% from 2024 to 2032. By 2030, the market is projected to reach approximately $229 million, with a CAGR of 5.2% from 2021 to 2030[3][5].

Market Segmentation

By Form

The dihydrate segment of zinc acetate holds the highest market share, accounting for more than two-thirds of the global market. This segment is expected to maintain its leadership and exhibit the highest CAGR of 5.4% from 2021 to 2030 due to its wide range of applications in dietary products, medicines, and chemicals[3].

By Application

The dietary and medicine segment dominates the market, contributing nearly two-thirds of the global zinc acetate market. This segment is projected to maintain its lead position and portray the largest CAGR of 5.4% from 2021 to 2030. Zinc acetate is used as a feed and food additive, in supplements, animal feed, capsules, tablets, astringents, and lozenges[3].

Regional Market Dynamics

Asia-Pacific and North America are the leading regions in the zinc acetate market. North America's food and beverage industry, particularly, has shown a growing interest in fortifying products with essential nutrients like zinc, contributing significantly to the market growth[2][3].

Prime Determinants of Growth

Pharmaceutical Sector

The increasing demand for zinc acetate in the pharmaceutical sector is a major driver of market growth. Zinc acetate's therapeutic properties make it a valuable ingredient in numerous pharmaceutical products, including over-the-counter cold treatments and astringents. As the demand for these remedies rises, the pharmaceutical industry is expected to rely more heavily on zinc acetate[5].

Animal Feed and Wood Preservation

The expansion of the animal feed market and the surge in demand for wood preservation chemicals also drive the growth of the global zinc acetate market. Zinc acetate is used as a feed additive and in wood preservation due to its effective properties[3].

Nutritional Fortification

Governments and organizations worldwide are implementing food fortification programs, particularly in developing regions, which presents significant growth opportunities for zinc acetate suppliers. This trend is driven by consumer preferences for healthier and functional food options[2].

Challenges and Opportunities

Availability of Alternatives

The availability of other zinc-based alternatives can hinder the market growth of zinc acetate. However, the rise in use of zinc acetate in various applications presents new opportunities in the coming years[3].

Environmental Concerns

Environmental concerns may pose restrictions on the market's expansion, but the overall demand and diverse applications of zinc acetate are expected to outweigh these challenges[5].

Impact of COVID-19

The COVID-19 pandemic has had a positive impact on the growth of the global zinc acetate market. The increased demand for zinc-based supplements during the pandemic has boosted the market, contributing to its growth[3].

Key Takeaways

• Clinical Trials: Ongoing trials are investigating the feasibility and safety of zinc acetate in specific medical conditions, such as GNAO1 associated disorders.
• Market Growth: The global zinc acetate market is projected to grow at a CAGR of 5.2-5.3% from 2021 to 2030, reaching approximately $229 million by 2030.
• Market Segmentation: The dihydrate segment and the dietary & medicine segment are the leading segments in terms of market share and growth.
• Regional Dynamics: Asia-Pacific and North America are the dominant regions in the zinc acetate market.
• Growth Drivers: The pharmaceutical sector, animal feed market, and nutritional fortification programs are key drivers of market growth.

FAQs

What is the primary application of zinc acetate in the pharmaceutical sector?

Zinc acetate is primarily used in the pharmaceutical sector for its therapeutic properties, including as an ingredient in dietary supplements, medicines, astringents, and over-the-counter cold treatments.

How does the COVID-19 pandemic impact the zinc acetate market?

The COVID-19 pandemic has positively impacted the zinc acetate market by increasing the demand for zinc-based supplements, thereby boosting market growth.

What are the main segments driving the growth of the zinc acetate market?

The dihydrate segment and the dietary & medicine segment are the main drivers of the zinc acetate market, contributing significantly to its growth.

Which regions dominate the zinc acetate market?

Asia-Pacific and North America are the dominant regions in the zinc acetate market, with North America's food and beverage industry showing a particular interest in zinc fortification.

What are the potential challenges facing the zinc acetate market?

The availability of other zinc-based alternatives and environmental concerns are potential challenges that could hinder the market growth of zinc acetate.

Sources

1. Prospective Pilot Trial to Address Feasibility and Safety of Oral Zinc in Patients Affected by Guanine Nucleotide-Binding Protein G(o) Subunit Alpha (GNAO1) Associated Disorders. CTV Veeva.
2. Global Zinc Acetate Market Size, Share & Trends Analysis Report By KBV Research. GIIR Research.
3. Zinc Acetate Market to Garner $229.0 Million, Globally, By 2030 at 5.2% CAGR, Says Allied Market Research. PR Newswire.
4. Effect of Treatment with Zinc Gluconate or Zinc Acetate on Experimental and Natural Colds. Oxford Academic.
5. Zinc Acetate Market, By Form, By Application, By Country, and By Region - Global Forecast to 2032. GIIR Research.