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Last Updated: April 13, 2024

CLINICAL TRIALS PROFILE FOR ZENATANE


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All Clinical Trials for Zenatane

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00026312 ↗ Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Active, not recruiting National Cancer Institute (NCI) Phase 3 2001-10-18 This partially randomized phase III trial studies isotretinoin with dinutuximab, aldesleukin, and sargramostim to see how well it works compared to isotretinoin alone following stem cell transplant in treating patients with neuroblastoma. Drugs used in chemotherapy, such as isotretinoin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as dinutuximab, may block tumor growth in different ways by targeting certain cells. Aldesleukin and sargramostim may stimulate a person's white blood cells to kill cancer cells. It is not yet known if chemotherapy is more effective with or without dinutuximab, aldesleukin, and sargramostim following stem cell transplant in treating neuroblastoma.
NCT00392327 ↗ Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Active, not recruiting National Cancer Institute (NCI) Phase 3 2007-03-26 This randomized phase III trial studies different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, high-risk medulloblastoma. Drugs used in chemotherapy, such as vincristine sulfate, cisplatin, cyclophosphamide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Carboplatin may make tumor cells more sensitive to radiation therapy. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating brain tumors.
NCT00392327 ↗ Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET Active, not recruiting Children's Oncology Group Phase 3 2007-03-26 This randomized phase III trial studies different chemotherapy and radiation therapy regimens to compare how well they work in treating young patients with newly diagnosed, previously untreated, high-risk medulloblastoma. Drugs used in chemotherapy, such as vincristine sulfate, cisplatin, cyclophosphamide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Carboplatin may make tumor cells more sensitive to radiation therapy. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating brain tumors.
NCT00867178 ↗ Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System Active, not recruiting National Cancer Institute (NCI) Phase 1 2009-02-25 This pilot clinical trial studies the side effects and the best way to give vorinostat with isotretinoin and combination chemotherapy and to see how well they work in treating younger patients with embryonal tumors of the central nervous system. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as isotretinoin, vincristine sulfate, cisplatin, cyclophosphamide, and etoposide phosphate, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving vorinostat with isotretinoin and combination chemotherapy may be an effective treatment for embryonal tumors of the central nervous system. A peripheral blood stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy. This may allow more chemotherapy to be given so that more tumor cells are killed.
NCT01041638 ↗ Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma Completed National Cancer Institute (NCI) Phase 3 2009-12-21 This phase III trial is studying the side effects of giving monoclonal antibody Ch14.18 together with sargramostim, aldesleukin, and isotretinoin after autologous stem cell transplant in treating patients with neuroblastoma. Monoclonal antibodies, such as Ch14.18, may find tumor cells and help kill them. Colony-stimulating factors, such as sargramostim, may increase the number of immune cells found in bone marrow or peripheral blood. Aldesleukin may stimulate the white blood cells to kill tumor cells. Isotretinoin may help neuroblastoma cells become more like normal cells, and to grow and spread more slowly. Giving monoclonal antibody Ch14.18 with sargramostim, aldesleukin, and isotretinoin after autologous stem cell transplant may be an effective treatment for neuroblastoma.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Zenatane

Condition Name

Condition Name for Zenatane
Intervention Trials
Stage 4 Neuroblastoma 3
High Risk Neuroblastoma 3
Recurrent Neuroblastoma 3
Stage 4S Neuroblastoma 2
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Condition MeSH

Condition MeSH for Zenatane
Intervention Trials
Neuroblastoma 6
Ganglioneuroblastoma 3
Neuroectodermal Tumors, Primitive 2
Neuroectodermal Tumors 2
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Clinical Trial Locations for Zenatane

Trials by Country

Trials by Country for Zenatane
Location Trials
United States 218
Canada 23
Australia 13
New Zealand 4
Puerto Rico 3
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Trials by US State

Trials by US State for Zenatane
Location Trials
California 8
Pennsylvania 8
New York 8
Texas 7
Tennessee 7
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Clinical Trial Progress for Zenatane

Clinical Trial Phase

Clinical Trial Phase for Zenatane
Clinical Trial Phase Trials
Phase 3 4
Phase 2 2
Phase 1 2
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Clinical Trial Status

Clinical Trial Status for Zenatane
Clinical Trial Phase Trials
Active, not recruiting 5
Recruiting 2
Completed 1
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Clinical Trial Sponsors for Zenatane

Sponsor Name

Sponsor Name for Zenatane
Sponsor Trials
National Cancer Institute (NCI) 8
Children's Oncology Group 3
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Sponsor Type

Sponsor Type for Zenatane
Sponsor Trials
NIH 8
Other 3
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