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Last Updated: October 1, 2020

DrugPatentWatch Database Preview

CLINICAL TRIALS PROFILE FOR ZANUBRUTINIB

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All Clinical Trials for Zanubrutinib

Trial ID Title Status Sponsor Phase Start Date Summary
NCT03432884 A Two-Part Phase 1 Study to Investigate the Safety and Tolerability of Supratherapeutic Dose of Zanubrutinib and Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects Completed BeiGene Phase 1 2018-01-25 A Two-Part Phase 1 Study to Investigate A) Safety and Tolerability of Supratherapeutic dose of Zanubrutinib (BGB-3111) and B) Effect of Zanubrutinib on Cardiac Repolarization in Healthy Subjects
NCT03465059 Safety and Pharmacokinetics of Zanubrutinib (BGB-3111) in Healthy Subjects and Those With Impaired Liver Function Active, not recruiting BeiGene Phase 1 2018-05-30 This study is designed to evaluate the safety and pharmacokinetics of zanubrutinib in subjects with impaired liver function in comparison with healthy subjects
NCT03561298 A Pharmacokinetic Study to Assess Drug-drug Interaction Between Zanubrutinib and a Cocktail of Substrates in Healthy Subjects Completed BeiGene Phase 1 2018-06-07 This study is designed to evaluate the safety and pharmacokinetic interaction of effects of multiple doses of zanubrutinib with a "Cocktail" of five probe drugs for cytochrome P450 (CYP) 3A, CYP2C9, CYP2C19, P-glycoprotein and breast cancer resistance protein (BCRP) in healthy subjects
NCT03734016 A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia Recruiting BeiGene Phase 3 2018-11-05 This study is designed to compare the overall response rate of zanubrutinib versus ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.
NCT03824483 Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL) Not yet recruiting BeiGene USA, Inc. Phase 2 2019-02-01 The purpose of this study is to determine the rate of minimum residual disease (MRD) negative response (i.e. the rate of no evidence of disease) of the study drugs, zanubrutinib, obinutuzumab, and venetoclax, given in combination as a treatment for CLL and/or SLL.
NCT03824483 Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL) Not yet recruiting Massachusetts General Hospital Phase 2 2019-02-01 The purpose of this study is to determine the rate of minimum residual disease (MRD) negative response (i.e. the rate of no evidence of disease) of the study drugs, zanubrutinib, obinutuzumab, and venetoclax, given in combination as a treatment for CLL and/or SLL.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Zanubrutinib

Condition Name

Condition Name for Zanubrutinib
Intervention Trials
Healthy Volunteers 2
Small Lymphocytic Lymphoma 2
Marginal Zone Lymphoma 2
Chronic Lymphocytic Leukemia (CLL) 2
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Condition MeSH

Condition MeSH for Zanubrutinib
Intervention Trials
Lymphoma 7
Leukemia, Lymphocytic, Chronic, B-Cell 5
Leukemia, Lymphoid 4
Leukemia 4
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Clinical Trial Locations for Zanubrutinib

Trials by Country

Trials by Country for Zanubrutinib
Location Trials
United States 19
Australia 8
Japan 7
China 3
Korea, Republic of 1
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Trials by US State

Trials by US State for Zanubrutinib
Location Trials
Florida 4
New Jersey 4
New York 3
Nevada 2
Texas 1
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Clinical Trial Progress for Zanubrutinib

Clinical Trial Phase

Clinical Trial Phase for Zanubrutinib
Clinical Trial Phase Trials
Phase 3 3
Phase 2 8
Phase 1/Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Zanubrutinib
Clinical Trial Phase Trials
Not yet recruiting 10
Recruiting 5
Completed 3
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Clinical Trial Sponsors for Zanubrutinib

Sponsor Name

Sponsor Name for Zanubrutinib
Sponsor Trials
BeiGene 14
Memorial Sloan Kettering Cancer Center 1
Roche-Genentech 1
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Sponsor Type

Sponsor Type for Zanubrutinib
Sponsor Trials
Industry 16
Other 6
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Serving leading biopharmaceutical companies globally:

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McKinsey

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