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Generated: December 9, 2018

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CLINICAL TRIALS PROFILE FOR ZANTAC

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Clinical Trials for Zantac

Trial ID Title Status Sponsor Phase Summary
NCT00223691 Treatment of Orthostatic Hypotension in Autonomic Failure Recruiting Vanderbilt University Medical Center Phase 3 The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.
NCT00233935 Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett's Esophagus Completed National Cancer Institute (NCI) Phase 1 The goal of this clinical research study is to test the safety of defined green tea catechin extract at different dose levels. Researchers also want to find out what effects, good and bad, it may have on individual and their risk for esophagus cancer. Esophagus cancer is an increased risk associated with Barrett's esophagus. Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of defined green tea catechin extract may prevent esophageal cancer.
NCT00443963 Total Antioxidant Effects of Esomeprazole in Dyspeptic Patients Receiving Non-Steroidal Anti-Inflammatory Drugs Terminated AstraZeneca Phase 4 We hypothesize that patients receiving NSAID drugs with dyspeptic symptoms have increased production of gastric levels of free radicals. The primary objective of the study is to determine if Esomeprazole Magnesium increases gastric total antioxidant capacity and decreases gastric free radical production in humans. Patients (age 18 years and older) with no history of upper GI bleeding who are receiving non-steroidal anti-inflammatory drugs and then develop dyspepsia will be recruited from our primary care clinic in Washington, DC. All eligible individuals will undergo biopsies of antrum and corpus. The subjects will be randomized to receive either Zantac OTC or Nexium for 15 days. On day 15, all patients will undergo repeat upper endoscopy to obtain biopsies of antrum and corpus. Tissue samples will then be extracted to determine total antioxidant capacity and lipid peroxide levels (as an indirect marker of free radical production).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Zantac

Condition Name

Condition Name for Zantac
Intervention Trials
Healthy 2
Spinal-induced Hypotension 1
Colorectal Cancer 1
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Condition MeSH

Condition MeSH for Zantac
Intervention Trials
Hypotension 2
Fallopian Tube Neoplasms 1
Mesothelioma 1
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Clinical Trial Locations for Zantac

Trials by Country

Trials by Country for Zantac
Location Trials
United States 7
Pakistan 2
Canada 2
Egypt 1
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Trials by US State

Trials by US State for Zantac
Location Trials
Maryland 2
Massachusetts 1
District of Columbia 1
Texas 1
New York 1
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Clinical Trial Progress for Zantac

Clinical Trial Phase

Clinical Trial Phase for Zantac
Clinical Trial Phase Trials
Phase 4 3
Phase 3 1
Phase 2 4
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Clinical Trial Status

Clinical Trial Status for Zantac
Clinical Trial Phase Trials
Completed 5
Not yet recruiting 3
Terminated 2
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Clinical Trial Sponsors for Zantac

Sponsor Name

Sponsor Name for Zantac
Sponsor Trials
Benazir Bhutto Hospital, Rawalpindi 2
National Cancer Institute (NCI) 2
Dalhousie University 1
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Sponsor Type

Sponsor Type for Zantac
Sponsor Trials
Other 10
Industry 4
NIH 3
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Serving hundreds of leading biopharmaceutical companies globally:

Citi
Dow
US Army
Fish and Richardson
UBS
McKinsey
Chinese Patent Office
Cerilliant
AstraZeneca

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