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Generated: December 11, 2018

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CLINICAL TRIALS PROFILE FOR XYLOCAINE

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Clinical Trials for Xylocaine

Trial ID Title Status Sponsor Phase Summary
NCT00014040 Nitric Oxide Inhalation Therapy to Relieve Chest Pain in Patients With Coronary Artery Disease Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 2 This study will test whether inhaling nitric oxide gas can improve blood flow to the heart, ventricular function, exercise tolerance in patients with coronary artery disease and chest pain that has not improved with medical or surgical therapy. Patients with coronary artery disease who have chest pain despite treatment with medicines and angioplasty or surgery may be eligible for this study. Those enrolled will receive monetary compensation for their participation in this study. The duration of the study is 5 days, with 2 testing periods lasting 2 days each. During one of the periods, the study participants will breathe nitric oxide mixed with room air through a face mask during the tests. During the other period, the participants will breathe room air alone through a face mask during the tests. At least 1 day will separate the treatment periods. During each of the 2 treatment periods (nitric oxide and room air), participants will undergo 4 tests to determine whether the treatment improves the heart's response to stress with increased heart rate and contraction. Approximately one hour before each of the tests, participants will breathe either nitric oxide mixed with room air or room air alone through the face mask, and continue the inhalation treatment while each test is being performed. The face mask will be removed at the end of each test. On the morning of the first day of each treatment period, participants will have a special echocardiogram with imaging of the heart. The echocardiogram will be performed during an infusion of dobutamine, a medicine that increases heart rate and contraction, and serves to stress the heart. This manner of stress testing is commonly used in hospitals around the country to determine if walls of the heart are receiving sufficient blood supply. That afternoon, participants will undergo a magnetic resonance imaging (MRI) study of the heart. The MRI will determine the heart's blood flow and contraction while receiving the same dosage of dobutamine as was used earlier in the day. On the morning of the second day of each treatment period, participants will exercise on a treadmill until moderately uncomfortable chest pain is reported. Later that morning, participants will undergo cardiac catheterization. For the cardiac catheterization, a long tube (catheter) will be placed into a vein of the neck once the skin is numbed with xylocaine. This tube will be positioned within the right atrium of the heart and into a tube-like structure called the coronary sinus, where venous blood exits the heart muscle. A small catheter will also be placed in an artery of the upper forearm after the skin has been numbed with xylocaine. Blood samples will be taken to allow us to measure the amount of nitric oxide transported in the blood. The blood samples will be drawn (through the tube in the heart and through the small tube in the artery) at the beginning of the study and during infusion of dobutamine to stress the heart. The dose of the dobutamine infusion will be the same dose used in the previous day's stress studies. After the completion of the first treatment period, we will stop testing for at least one day. Participants will begin the second treatment period with the inhalation treatment not received during the first treatment period.
NCT00219713 Evaluation of Pain Intensity During Bone Marrow Biopsy Performed With Inhalation of Pre-Mixed 50 Per Cent Nitrous Oxide and Oxygen Mixture. Terminated Air Liquide Santé International Phase 3 Bone marrow biopsy is a painful medical procedure often performed with local anesthetic. Therefore a double-blind, randomized, controlled trial was carried out in 330 adult patients who where referred for bone marrow biopsy and aspiration. 164 were assigned to inhale an equimolar mixture of nitrous oxide and oxygen and 166 to inhale a placebo. Pain measurement used visual-analogue pain scales, which involve rating the intensity of pain on a horizontal ruler
NCT00219713 Evaluation of Pain Intensity During Bone Marrow Biopsy Performed With Inhalation of Pre-Mixed 50 Per Cent Nitrous Oxide and Oxygen Mixture. Terminated Ministry of Health, France Phase 3 Bone marrow biopsy is a painful medical procedure often performed with local anesthetic. Therefore a double-blind, randomized, controlled trial was carried out in 330 adult patients who where referred for bone marrow biopsy and aspiration. 164 were assigned to inhale an equimolar mixture of nitrous oxide and oxygen and 166 to inhale a placebo. Pain measurement used visual-analogue pain scales, which involve rating the intensity of pain on a horizontal ruler
NCT00219713 Evaluation of Pain Intensity During Bone Marrow Biopsy Performed With Inhalation of Pre-Mixed 50 Per Cent Nitrous Oxide and Oxygen Mixture. Terminated Poitiers University Hospital Phase 3 Bone marrow biopsy is a painful medical procedure often performed with local anesthetic. Therefore a double-blind, randomized, controlled trial was carried out in 330 adult patients who where referred for bone marrow biopsy and aspiration. 164 were assigned to inhale an equimolar mixture of nitrous oxide and oxygen and 166 to inhale a placebo. Pain measurement used visual-analogue pain scales, which involve rating the intensity of pain on a horizontal ruler
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Xylocaine

Condition Name

Condition Name for Xylocaine
Intervention Trials
Pain 5
Anesthesia, Local 3
Pain, Postoperative 2
Conscious Sedation 2
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Condition MeSH

Condition MeSH for Xylocaine
Intervention Trials
Pain, Postoperative 5
Fasciitis, Plantar 2
Fasciitis 2
Syndrome 2
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Clinical Trial Locations for Xylocaine

Trials by Country

Trials by Country for Xylocaine
Location Trials
United States 19
Egypt 8
France 5
Canada 5
Taiwan 3
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Trials by US State

Trials by US State for Xylocaine
Location Trials
California 5
New York 3
North Carolina 2
Texas 2
Ohio 2
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Clinical Trial Progress for Xylocaine

Clinical Trial Phase

Clinical Trial Phase for Xylocaine
Clinical Trial Phase Trials
Phase 4 18
Phase 3 6
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Xylocaine
Clinical Trial Phase Trials
Completed 20
Recruiting 12
Not yet recruiting 9
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Clinical Trial Sponsors for Xylocaine

Sponsor Name

Sponsor Name for Xylocaine
Sponsor Trials
Loma Linda University 3
Bassett Healthcare 2
Ain Shams University 2
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Sponsor Type

Sponsor Type for Xylocaine
Sponsor Trials
Other 61
Industry 3
NIH 3
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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Healthtrust
Mallinckrodt
Colorcon
Medtronic
US Department of Justice
Fish and Richardson
Cerilliant
Chinese Patent Office

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