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Last Updated: January 27, 2023

CLINICAL TRIALS PROFILE FOR VIRAZOLE


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All Clinical Trials for Virazole

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00018031 ↗ Peginterferon Alpha-2b And Ribavirin to Treat Hepatitis C in HIV-Infected Patients Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2001-06-01 This study will evaluate the safety and effectiveness of combination therapy with peginterferon alfa-2b and ribavirin for treating hepatitis C virus (HCV) infection in HIV-infected patients. In studies of patients with hepatitis C alone, interferon alfa-2b plus ribavirin treatment eradicated the HCV in almost half the patients. Peginterferon alfa-2b is a compound that results from attaching a polyethylene glycol molecule to interferon alfa-2b. This compound stays in the blood longer than unmodified interferon alfa-2b, causing a higher blood concentration and thus maintaining activity against the hepatitis C virus. HIV-infected patients 21 years of age and older with chronic hepatitis C infection and a viral load greater than 2000 copies/mL may be eligible for this 2 1/2-year study. Candidates will be screened with blood and urine tests and possibly a liver biopsy, if a recent one is not available. The liver biopsy is done to determine the severity of liver disease. For this test, patients are admitted to the NIH Clinical Center for 1 to 2 days. A sedative is injected into an arm vein, the skin in the area over the biopsy site is numbed with a local anesthetic, and a needle is inserted rapidly into and out of the liver to obtain a small tissue sample. The patient remains in the hospital overnight for monitoring. A chest X-ray, electrocardiogram (EKG) and liver ultrasound are also done. Within 4 weeks of the screening tests, candidates who appear eligible for the study will have a physical examination, medical history and repeat blood tests. Women who can become pregnant will have serial pregnancy tests throughout the study. Patients who meet the study criteria and decide to participate will begin treatment with weekly injections under the skin of peginterferon alfa-2b and take ribavirin pills twice a day by mouth. In addition, patients will continue to take all other medications prescribed by their doctor. Clinic visits will be scheduled as follows: - Days 1, 3, 5, 7, 10 and 21 - Blood will be drawn for safety tests and to measure blood levels of HIV and HCV. - Weeks 2, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 52, 56 and 64 - Blood and urine tests will be done to determine the side effects of treatment and its effect on the HCV infection. - Week 48 or end of treatment - Treatment will stop after 48 weeks. At this time, or earlier for those who do not complete the 48 weeks, patients will return to the clinic for a routine test.
NCT00446134 ↗ Taribavirin Phase 2 Dose Finding Study for the Treatment of Hepatitis C Virus (HCV) Completed Bausch Health Americas, Inc. Phase 2 2007-03-01 The objective of the study is to select an optimal dose of taribavirin by comparing the efficacy and safety of 3 taribavirin dose levels, 20, 25, and 30 mg/kg/day, versus ribavirin 800 to 1400 mg/day based on body weight, both administered in combination with peginterferon alfa-2b to therapy-naive patients with chronic Hepatitis C Virus (HCV) genotype 1 infection.
NCT00446134 ↗ Taribavirin Phase 2 Dose Finding Study for the Treatment of Hepatitis C Virus (HCV) Completed Valeant Pharmaceuticals International, Inc. Phase 2 2007-03-01 The objective of the study is to select an optimal dose of taribavirin by comparing the efficacy and safety of 3 taribavirin dose levels, 20, 25, and 30 mg/kg/day, versus ribavirin 800 to 1400 mg/day based on body weight, both administered in combination with peginterferon alfa-2b to therapy-naive patients with chronic Hepatitis C Virus (HCV) genotype 1 infection.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Virazole

Condition Name

Condition Name for Virazole
Intervention Trials
Hepatitis C 3
COVID19 2
Hepatitis C Infection 2
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Condition MeSH

Condition MeSH for Virazole
Intervention Trials
Hepatitis C 8
Hepatitis 8
Hepatitis A 6
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Clinical Trial Locations for Virazole

Trials by Country

Trials by Country for Virazole
Location Trials
United States 8
Germany 2
Greece 2
Australia 1
Canada 1
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Trials by US State

Trials by US State for Virazole
Location Trials
California 3
Texas 2
New York 1
Virginia 1
Maryland 1
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Clinical Trial Progress for Virazole

Clinical Trial Phase

Clinical Trial Phase for Virazole
Clinical Trial Phase Trials
Phase 4 1
Phase 2 5
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Virazole
Clinical Trial Phase Trials
Completed 9
Terminated 2
Not yet recruiting 1
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Clinical Trial Sponsors for Virazole

Sponsor Name

Sponsor Name for Virazole
Sponsor Trials
Bausch Health Americas, Inc. 4
Merck Sharp & Dohme Corp. 2
U.S. Army Medical Research and Development Command 2
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Sponsor Type

Sponsor Type for Virazole
Sponsor Trials
Industry 11
Other 6
U.S. Fed 3
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