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Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR VINCREX

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Clinical Trials for Vincrex

Trial ID Title Status Sponsor Phase Summary
NCT02043587 Chemotherapy With Liposomal Cytarabine CNS Prophylaxis for Adult Acute Lymphoblastic Leukemia & Lymphoblastic Lymphoma Recruiting Sigma Tau Pharmaceuticals, Inc. Phase 2 The objective of this protocol is to improve survival for adults with acute lymphoblastic leukemia or acute lymphoblastic lymphoma by reducing systemic and central nervous system (CNS) relapse with acceptable toxicity using intensive chemotherapy with liposomal cytarabine (Depocyt®) CNS prophylaxis.
NCT02043587 Chemotherapy With Liposomal Cytarabine CNS Prophylaxis for Adult Acute Lymphoblastic Leukemia & Lymphoblastic Lymphoma Recruiting University of California, San Diego Phase 2 The objective of this protocol is to improve survival for adults with acute lymphoblastic leukemia or acute lymphoblastic lymphoma by reducing systemic and central nervous system (CNS) relapse with acceptable toxicity using intensive chemotherapy with liposomal cytarabine (Depocyt®) CNS prophylaxis.
NCT02110069 A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Recruiting Food and Drug Administration (FDA) Phase 2 In this research study we want to learn more about which treatment works better for patients diagnosed with a vascular tumor called Kaposiform Hemangioendothelioma (KHE) or other high risk vascular tumors such as Tufted Angioma (TA). In these tumors, the blood cells that help your blood clot called platelets become trapped in the tumor causing swelling, pain, and bruising. Vascular tumors can be life threatening. There are few medical treatments that will work to shrink the vascular tumor. Some doctors will use steroids and vincristine to try and shrink vascular tumors. In this research study, the study doctor will compare two different drugs to see which one will work better to help shrink your vascular tumor. One of the drugs is vincristine. Vincristine is approved by the Food and Drug Administration (FDA) to treat people with cancer. Vincristine is used to stop the abnormal cells from growing such as cells that make up blood vessels. The other drug to be used in this study is sirolimus. Sirolimus is currently approved by the Food and Drug Administration (FDA) to prevent transplanted organ rejection. Sirolimus is not approved by the FDA for treatment of vascular abnormalities and is considered experimental. Sirolimus belongs to a class of drugs call 'mTOR inhibitors'. mTOR (mammilian target of rapamycin) helps cells to grow and may also help blood vessels to grow in a more normal fashion. Sirolimus is currently being tested in patients with vascular tumors and cancer. In vascular tumors, we hope sirolimus will stop the blood vessel growth. Funding Source: FDA - OOPD (Office of Orphan Products Development)
NCT02110069 A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Recruiting Pfizer Phase 2 In this research study we want to learn more about which treatment works better for patients diagnosed with a vascular tumor called Kaposiform Hemangioendothelioma (KHE) or other high risk vascular tumors such as Tufted Angioma (TA). In these tumors, the blood cells that help your blood clot called platelets become trapped in the tumor causing swelling, pain, and bruising. Vascular tumors can be life threatening. There are few medical treatments that will work to shrink the vascular tumor. Some doctors will use steroids and vincristine to try and shrink vascular tumors. In this research study, the study doctor will compare two different drugs to see which one will work better to help shrink your vascular tumor. One of the drugs is vincristine. Vincristine is approved by the Food and Drug Administration (FDA) to treat people with cancer. Vincristine is used to stop the abnormal cells from growing such as cells that make up blood vessels. The other drug to be used in this study is sirolimus. Sirolimus is currently approved by the Food and Drug Administration (FDA) to prevent transplanted organ rejection. Sirolimus is not approved by the FDA for treatment of vascular abnormalities and is considered experimental. Sirolimus belongs to a class of drugs call 'mTOR inhibitors'. mTOR (mammilian target of rapamycin) helps cells to grow and may also help blood vessels to grow in a more normal fashion. Sirolimus is currently being tested in patients with vascular tumors and cancer. In vascular tumors, we hope sirolimus will stop the blood vessel growth. Funding Source: FDA - OOPD (Office of Orphan Products Development)
NCT02110069 A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Recruiting Boston Children’s Hospital Phase 2 In this research study we want to learn more about which treatment works better for patients diagnosed with a vascular tumor called Kaposiform Hemangioendothelioma (KHE) or other high risk vascular tumors such as Tufted Angioma (TA). In these tumors, the blood cells that help your blood clot called platelets become trapped in the tumor causing swelling, pain, and bruising. Vascular tumors can be life threatening. There are few medical treatments that will work to shrink the vascular tumor. Some doctors will use steroids and vincristine to try and shrink vascular tumors. In this research study, the study doctor will compare two different drugs to see which one will work better to help shrink your vascular tumor. One of the drugs is vincristine. Vincristine is approved by the Food and Drug Administration (FDA) to treat people with cancer. Vincristine is used to stop the abnormal cells from growing such as cells that make up blood vessels. The other drug to be used in this study is sirolimus. Sirolimus is currently approved by the Food and Drug Administration (FDA) to prevent transplanted organ rejection. Sirolimus is not approved by the FDA for treatment of vascular abnormalities and is considered experimental. Sirolimus belongs to a class of drugs call 'mTOR inhibitors'. mTOR (mammilian target of rapamycin) helps cells to grow and may also help blood vessels to grow in a more normal fashion. Sirolimus is currently being tested in patients with vascular tumors and cancer. In vascular tumors, we hope sirolimus will stop the blood vessel growth. Funding Source: FDA - OOPD (Office of Orphan Products Development)
NCT02228772 Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults Recruiting Millennium Pharmaceuticals, Inc. Phase 1 This research study is evaluating a combination of drugs considered standard treatment for children and young adults with acute lymphoblastic leukemia (ALL), in combination with a new drug called MLN 9708. Additionally, the study is also evaluating if bone marrow or stem cell transplantation, which will be given to some participants, helps to prevent ALL from returning.
NCT02228772 Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults Recruiting Massachusetts General Hospital Phase 1 This research study is evaluating a combination of drugs considered standard treatment for children and young adults with acute lymphoblastic leukemia (ALL), in combination with a new drug called MLN 9708. Additionally, the study is also evaluating if bone marrow or stem cell transplantation, which will be given to some participants, helps to prevent ALL from returning.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Vincrex

Condition Name

Condition Name for Vincrex
Intervention Trials
CD20 Positive 2
Adult Lymphoblastic Lymphoma 2
B-Cell Non-Hodgkin Lymphoma 2
Philadelphia Chromosome Positive 2
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Condition MeSH

Condition MeSH for Vincrex
Intervention Trials
Lymphoma 5
Lymphoma, Non-Hodgkin 5
Leukemia, Lymphoid 4
Leukemia 4
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Clinical Trial Locations for Vincrex

Trials by Country

Trials by Country for Vincrex
Location Trials
United States 38
Tanzania 1
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Trials by US State

Trials by US State for Vincrex
Location Trials
Massachusetts 3
Pennsylvania 3
Illinois 2
North Carolina 2
Maryland 2
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Clinical Trial Progress for Vincrex

Clinical Trial Phase

Clinical Trial Phase for Vincrex
Clinical Trial Phase Trials
Phase 3 2
Phase 2/Phase 3 1
Phase 2 4
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Clinical Trial Status

Clinical Trial Status for Vincrex
Clinical Trial Phase Trials
Recruiting 7
Not yet recruiting 4
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Clinical Trial Sponsors for Vincrex

Sponsor Name

Sponsor Name for Vincrex
Sponsor Trials
National Cancer Institute (NCI) 8
Children's Oncology Group 3
University of Washington 1
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Sponsor Type

Sponsor Type for Vincrex
Sponsor Trials
Other 13
NIH 8
Industry 4
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Serving hundreds of leading biopharmaceutical companies globally:

McKinsey
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Boehringer Ingelheim
Healthtrust
Daiichi Sankyo
Harvard Business School
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