The purpose of this study was to assess the effects of patiromer on serum potassium
participants with heart failure. This study also assessed the safety and tolerability of
patiromer in participants with heart failure.
The purpose of this study was to assess the effects of patiromer on serum potassium
participants with heart failure. This study also assessed the safety and tolerability of
patiromer in participants with heart failure.
Evaluation of Patiromer Titration in Heart Failure Patients With Chronic Kidney Disease
Completed
Relypsa, Inc.
Phase 2
2010-05-01
The purpose of this study was to evaluate the feasibility of individualized titration of
patiromer according to serum potassium. This study also assessed the safety and tolerability
of patiromer and the effects of patiromer on serum potassium in heart failure (HF)
participants with chronic kidney disease (CKD).
Patiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)
Completed
Relypsa, Inc.
Phase 2
2011-06-01
This study determined the optimal starting dose of patiromer in treating hyperkalemia in
participants with hypertension and diabetic nephropathy who were already receiving ACEI
and/or ARB drugs, with or without spironolactone. This study also evaluated the efficacy and
safety of patiromer and the long term use of patiromer.
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