A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients
The purpose of this study is to see if valacyclovir (Valtrex) is a safe and effective
treatment for ano-genital HSV infections (herpes simplex virus infections of the anus and
external genitals) in HIV-infected patients.
Allo Transplantation With Mylotarg, Fludarabine and Melphalan for AML, CML and MDS
M.D. Anderson Cancer Center
Phase 1/Phase 2
The goal of this clinical research study is to find the highest safe dose of Mylotarg that
can be combined with chemotherapy in patients receiving allogeneic bone marrow
transplantation. Researchers will study the effects of this treatment combination on
patients with high-risk acute leukemia, chronic myelogenous leukemia, or myelodysplastic
1. To determine the safety and maximum tolerated dose of Mylotarg as part of a
reduced-intensity preparative regimen patients undergoing related, mismatched-related or
matched unrelated donor transplantation.
1. To evaluate response rates, engraftment kinetics and degree of chimerism achievable
with this strategy.
2. To evaluate the incidence and severity of GVHD in this population
3. To evaluate disease-free and overall survival and relapse rates.
A Study of Valacyclovir to Suppress HSV and HIV Shedding in Coinfected Persons
The primary objective of this research study is to assess if daily valacyclovir therapy for
suppression of HSV-2 reactivation is associated with a decrease in mucosal HIV shedding in
individuals co-infected with both HSV-2 and HIV.
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