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Last Updated: February 7, 2023

CLINICAL TRIALS PROFILE FOR VALCHLOR


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All Clinical Trials for Valchlor

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02296164 ↗ Clinical Study Assessing Outcomes, Adverse Events, Treatment Patterns, and Quality of Life in Patients Diagnosed With Mycosis Fungoides Cutaneous T-cell Lymphoma Completed Actelion 2014-11-12 The Valchlor PROVe study is a multi-center, prospective, observational, US-based drug study that longitudinally follows patients with Mycosis Fungoides Cutaneous T-cell Lymphoma (MF-CTCL) who are receiving therapy with Valchlor. Patients will be followed prospectively for a maximum of 2 years from the date of signed informed consent (enrollment) until end of study. Continuation in the study is not contingent on continuation of Valchlor.
NCT02296164 ↗ Clinical Study Assessing Outcomes, Adverse Events, Treatment Patterns, and Quality of Life in Patients Diagnosed With Mycosis Fungoides Cutaneous T-cell Lymphoma Completed Helsinn Therapeutics (U.S.), Inc 2014-11-12 The Valchlor PROVe study is a multi-center, prospective, observational, US-based drug study that longitudinally follows patients with Mycosis Fungoides Cutaneous T-cell Lymphoma (MF-CTCL) who are receiving therapy with Valchlor. Patients will be followed prospectively for a maximum of 2 years from the date of signed informed consent (enrollment) until end of study. Continuation in the study is not contingent on continuation of Valchlor.
NCT02881749 ↗ Low Dose Total Skin Electron Beam Treatment (TSEBT) Followed by Maintenance Valchlor for Patients With Mycosis Fungoides Unknown status Actelion Phase 2 2016-09-01 The clinical efficacy of mechlorethamine gel (Valchlor) as a maintenance therapy after low dose total skin electron beam therapy (TSEBT) for the treatment mycosis fungoides cutaneous T-cell lymphoma will be evaluated in this study. Subjects will be treated with low dose TSEBT (12 Gy total) over a period of two weeks. After a 30 day observation period and confirmation that their disease stage has been downgraded to IA or IB, subjects will use Valchlor as a maintenance therapy over the course of one year. The efficacy of Valchlor as a maintenance drug will be followed clinically through Modified Severity Weight Assessment Tool (mSWAT) and percent body surface area measurements (%BSA). Furthermore, subjects will be followed histopathologically through skin biopsies performed at the screening visit, immediately after observation period, one month after the start of the maintenance period, and twelve months after the start of the maintenance period (4 biopsies total).
NCT02881749 ↗ Low Dose Total Skin Electron Beam Treatment (TSEBT) Followed by Maintenance Valchlor for Patients With Mycosis Fungoides Unknown status Thomas Jefferson University Phase 2 2016-09-01 The clinical efficacy of mechlorethamine gel (Valchlor) as a maintenance therapy after low dose total skin electron beam therapy (TSEBT) for the treatment mycosis fungoides cutaneous T-cell lymphoma will be evaluated in this study. Subjects will be treated with low dose TSEBT (12 Gy total) over a period of two weeks. After a 30 day observation period and confirmation that their disease stage has been downgraded to IA or IB, subjects will use Valchlor as a maintenance therapy over the course of one year. The efficacy of Valchlor as a maintenance drug will be followed clinically through Modified Severity Weight Assessment Tool (mSWAT) and percent body surface area measurements (%BSA). Furthermore, subjects will be followed histopathologically through skin biopsies performed at the screening visit, immediately after observation period, one month after the start of the maintenance period, and twelve months after the start of the maintenance period (4 biopsies total).
NCT02968446 ↗ Effect of Vitamin D After Application With Valchlor Unknown status National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Early Phase 1 2016-11-17 The purpose of this research study is to evaluate the effects of an oral Vitamin D on the body's immune system. An interest has been growing because studies have shown that Vitamin D may reduce inflammation and harmful effects in the body, however, the best dose for Vitamin D is still unknown. Inflammation is the body's physical response to infection, injury, or long term disease. Pain, redness, heat, and sometimes loss of function are all signs of inflammation in the body. This study will look at product use, testing skin irritation in healthy volunteers and seeing how Vitamin D may help stop or reduce inflammation and skin irritation, which could one day help doctors prescribe Vitamin D to patients with long term disease to relieve their symptoms.
NCT02968446 ↗ Effect of Vitamin D After Application With Valchlor Unknown status National Institutes of Health (NIH) Early Phase 1 2016-11-17 The purpose of this research study is to evaluate the effects of an oral Vitamin D on the body's immune system. An interest has been growing because studies have shown that Vitamin D may reduce inflammation and harmful effects in the body, however, the best dose for Vitamin D is still unknown. Inflammation is the body's physical response to infection, injury, or long term disease. Pain, redness, heat, and sometimes loss of function are all signs of inflammation in the body. This study will look at product use, testing skin irritation in healthy volunteers and seeing how Vitamin D may help stop or reduce inflammation and skin irritation, which could one day help doctors prescribe Vitamin D to patients with long term disease to relieve their symptoms.
NCT02968446 ↗ Effect of Vitamin D After Application With Valchlor Unknown status Case Comprehensive Cancer Center Early Phase 1 2016-11-17 The purpose of this research study is to evaluate the effects of an oral Vitamin D on the body's immune system. An interest has been growing because studies have shown that Vitamin D may reduce inflammation and harmful effects in the body, however, the best dose for Vitamin D is still unknown. Inflammation is the body's physical response to infection, injury, or long term disease. Pain, redness, heat, and sometimes loss of function are all signs of inflammation in the body. This study will look at product use, testing skin irritation in healthy volunteers and seeing how Vitamin D may help stop or reduce inflammation and skin irritation, which could one day help doctors prescribe Vitamin D to patients with long term disease to relieve their symptoms.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Valchlor

Condition Name

Condition Name for Valchlor
Intervention Trials
Mycosis Fungoides 5
Cutaneous T-cell Lymphoma 2
Skin Irritation 1
Syringotropic Mycosis Fungoides 1
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Condition MeSH

Condition MeSH for Valchlor
Intervention Trials
Mycosis Fungoides 5
Mycoses 5
Lymphoma, T-Cell, Cutaneous 3
Lymphoma, T-Cell 3
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Clinical Trial Locations for Valchlor

Trials by Country

Trials by Country for Valchlor
Location Trials
United States 24
Netherlands 1
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Trials by US State

Trials by US State for Valchlor
Location Trials
Florida 2
Ohio 2
New York 2
Pennsylvania 2
Colorado 1
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Clinical Trial Progress for Valchlor

Clinical Trial Phase

Clinical Trial Phase for Valchlor
Clinical Trial Phase Trials
Phase 2 4
N/A 1
Early Phase 1 1
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Clinical Trial Status

Clinical Trial Status for Valchlor
Clinical Trial Phase Trials
Completed 2
Recruiting 2
Unknown status 2
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Clinical Trial Sponsors for Valchlor

Sponsor Name

Sponsor Name for Valchlor
Sponsor Trials
Actelion 4
Sidney Kimmel Cancer Center at Thomas Jefferson University 1
Rochester General Hospital 1
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Sponsor Type

Sponsor Type for Valchlor
Sponsor Trials
Other 8
Industry 6
NIH 2
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