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Last Updated: July 1, 2022

CLINICAL TRIALS PROFILE FOR UROKINASE


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All Clinical Trials for Urokinase

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00001713 ↗ Treatment for Blood Clots in the Veins of the Legs Completed National Institutes of Health Clinical Center (CC) Phase 1 1998-02-01 Acute deep venous thrombosis (ADVT) of the lower extremity is a common disorder. Traditional treatment with anticoagulation therapy is effective in reducing the associated risk of pulmonary embolism, but is ineffective in restoring patency of the venous system of the lower extremity. While systemic thrombolytic therapy has been shown to be more effective than anticoagulation, catheter directed local thrombolytic therapy is the most effective treatment in restoring venous patency. Current treatment regimens are based on use of urokinase, infused continuously through catheters imbedded into the thrombus. These treatment regimens require doses on the order of 10,000,000 units of urokinase, resulting in significant bleeding complications and prohibitive costs. Experience at NIH with pulse-spray treatment of axillary subclavian venous thrombosis with rtPA indicates that this is a highly effective and safe alternative thrombolytic regimen. The proposed protocol is designed to evaluate the efficiency, safety, and doses of rtPA associated with pulse spray directed rtPA treatment of the more extensive venous thrombosis encountered in the lower extremity.
NCT00083525 ↗ Urokinase-Plasminogen Activator (uPA) Inhibitor WX-UK1 in Combination With Capecitabine in Advanced Malignancies Completed United States Department of Defense Phase 1 2004-05-01 The purpose of this study is to determine the safety, tolerability, maximum tolerated dose (MTD), pharmacokinetics, and pharmacodynamics of the combination of WX-UK1 and capecitabine in patients with advanced malignancies.
NCT00083525 ↗ Urokinase-Plasminogen Activator (uPA) Inhibitor WX-UK1 in Combination With Capecitabine in Advanced Malignancies Completed Heidelberg Pharma AG Phase 1 2004-05-01 The purpose of this study is to determine the safety, tolerability, maximum tolerated dose (MTD), pharmacokinetics, and pharmacodynamics of the combination of WX-UK1 and capecitabine in patients with advanced malignancies.
NCT00083525 ↗ Urokinase-Plasminogen Activator (uPA) Inhibitor WX-UK1 in Combination With Capecitabine in Advanced Malignancies Completed Wilex Phase 1 2004-05-01 The purpose of this study is to determine the safety, tolerability, maximum tolerated dose (MTD), pharmacokinetics, and pharmacodynamics of the combination of WX-UK1 and capecitabine in patients with advanced malignancies.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Urokinase

Condition Name

Condition Name for Urokinase
Intervention Trials
Pleural Effusion 3
Diabetic Foot 3
Ischemic Stroke 2
Pulmonary Embolism 2
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Condition MeSH

Condition MeSH for Urokinase
Intervention Trials
Ischemia 8
Stroke 7
Ischemic Stroke 7
Empyema 6
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Clinical Trial Locations for Urokinase

Trials by Country

Trials by Country for Urokinase
Location Trials
China 55
United States 36
Denmark 8
Greece 5
Germany 4
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Trials by US State

Trials by US State for Urokinase
Location Trials
Tennessee 2
Colorado 2
Pennsylvania 2
California 2
Illinois 2
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Clinical Trial Progress for Urokinase

Clinical Trial Phase

Clinical Trial Phase for Urokinase
Clinical Trial Phase Trials
Phase 4 13
Phase 3 13
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for Urokinase
Clinical Trial Phase Trials
Completed 22
Unknown status 12
Terminated 8
[disabled in preview] 7
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Clinical Trial Sponsors for Urokinase

Sponsor Name

Sponsor Name for Urokinase
Sponsor Trials
Rigshospitalet, Denmark 6
General Hospital of Shenyang Military Region 3
Hellenic Institute for the Study of Sepsis 3
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Sponsor Type

Sponsor Type for Urokinase
Sponsor Trials
Other 137
Industry 18
NIH 2
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