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Generated: June 19, 2019

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CLINICAL TRIALS PROFILE FOR TRANDOLAPRIL

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Clinical Trials for Trandolapril

Trial ID Title Status Sponsor Phase Summary
NCT00000558 Prevention of Events With Angiotensin-Converting Enzyme Inhibitor Therapy (PEACE) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 To determine whether the addition of angiotensin converting enzyme (ACE) inhibitor to standard therapy in patients with known coronary artery disease and preserved left ventricular function will prevent cardiovascular mortality and reduce the risk of myocardial infarction.
NCT00133692 INVEST: INternational VErapamil SR Trandolapril STudy Completed Abbott Phase 4 Because blood pressure affects the heart, blood vessels, kidneys, and the entire body, it is important to keep it as normal as possible. There are several different ways to control blood pressure and to prevent or limit the development of heart disease due to high blood pressure. The purpose of this study is to compare two treatments to see how well they work and the difference in their side effects. One treatment includes the use of a calcium antagonist drug (Isoptin sustained release [SR] or Verapamil SR). The other treatment excludes the calcium antagonist and may include a non-calcium antagonist drug called a beta blocker (Tenormin or Atenolol). Both treatments may also include medication called angiotensin converting enzyme (ACE) inhibitors and water pills. None of the drugs in this study are experimental, they are all approved by the Food and Drug Administration (FDA).
NCT00133692 INVEST: INternational VErapamil SR Trandolapril STudy Completed University of Florida Phase 4 Because blood pressure affects the heart, blood vessels, kidneys, and the entire body, it is important to keep it as normal as possible. There are several different ways to control blood pressure and to prevent or limit the development of heart disease due to high blood pressure. The purpose of this study is to compare two treatments to see how well they work and the difference in their side effects. One treatment includes the use of a calcium antagonist drug (Isoptin sustained release [SR] or Verapamil SR). The other treatment excludes the calcium antagonist and may include a non-calcium antagonist drug called a beta blocker (Tenormin or Atenolol). Both treatments may also include medication called angiotensin converting enzyme (ACE) inhibitors and water pills. None of the drugs in this study are experimental, they are all approved by the Food and Drug Administration (FDA).
NCT00212901 High Dose Ace Inhibitor Therapy Versus Combination of ACE and ARB Therapy Completed Ottawa Hospital Research Institute N/A Investigation of wheather addition of angiotensin receptor blocker (Irbesartan) to recommended doses of angiotensin converting enzyme inhibitor (trandolapril) is more effective in decreasing amount of protein in urine in patients with diabetic kidney disease than high doses of trandolapril.
NCT00233532 Canadian Study of Trandolapril on Blood Pressure in Hypertensive Patients (TRAIL) Completed Abbott Phase 4 The TRAIL study was conducted to examine the effects of escalating doses of an ACE inhibitor, trandolapril, on lowering blood pressure in Stage 1-2 hypertensive patients.
NCT00234871 Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM) Completed Abbott Phase 4 The primary objective of this study is to determine if trandolapril/verapamil (Tarka®) is superior to amlodipine/benazepril (Lotrel®) in reduction of albuminuria in hypertensive subjects with Type 2 diabetes mellitus (DM) and diabetic nephropathy
NCT00252317 Acute Haemodynamic Effects of Treatment With Angiotensin Converting Enzyme (ACE)-Inhibitors in Patients With Symptomatic Aortic Stenosis Unknown status Rigshospitalet, Denmark Phase 4 Abundant evidence suggests that Angiotensin Converting Enzyme (ACE) inhibition potentially could reduce the hazardous effects of aortic stenosis and improve haemodynamics. The treatment seems safe even in patients with severe stenosis. There are however no randomised clinical trials that can confirm this hypothesis.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Trandolapril

Condition Name

Condition Name for Trandolapril
Intervention Trials
Hypertension 6
Healthy 4
Diabetes 4
Coronary Disease 1
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Condition MeSH

Condition MeSH for Trandolapril
Intervention Trials
Hypertension 5
Kidney Diseases 2
Diabetic Nephropathies 2
Coronary Disease 2
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Clinical Trial Locations for Trandolapril

Trials by Country

Trials by Country for Trandolapril
Location Trials
Italy 3
Canada 3
United States 3
India 2
Denmark 1
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Trials by US State

Trials by US State for Trandolapril
Location Trials
Florida 2
Nebraska 1
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Clinical Trial Progress for Trandolapril

Clinical Trial Phase

Clinical Trial Phase for Trandolapril
Clinical Trial Phase Trials
Phase 4 8
Phase 3 2
Phase 1 4
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Clinical Trial Status

Clinical Trial Status for Trandolapril
Clinical Trial Phase Trials
Completed 12
Unknown status 2
Enrolling by invitation 1
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Clinical Trial Sponsors for Trandolapril

Sponsor Name

Sponsor Name for Trandolapril
Sponsor Trials
Abbott 3
Dr. Reddy's Laboratories Limited 2
Teva Pharmaceuticals USA 2
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Sponsor Type

Sponsor Type for Trandolapril
Sponsor Trials
Other 10
Industry 8
NIH 2
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