Efficacy and Safety of Oral Bosentan in Patients With Idiopathic Pulmonary Fibrosis
Completed
Actelion
Phase 2/Phase 3
2003-08-01
Endothelin-1 (ET-1) is expressed in a variety of pulmonary pathological conditions including
pulmonary vascular disease and pulmonary fibrosis.
Bosentan (an oral dual ET-1 receptor antagonist) could delay the progression of idiopathic
pulmonary fibrosis (IPF), a condition for which no established treatment is available.
The present trial investigates a possible use of bosentan, which is currently approved for
the treatment of symptoms of pulmonary arterial hypertension (PAH) WHO class III and IV, to a
new category of patients suffering from IPF.
It was decided to offer Open Label treatment (bosentan) for patients willing to continue in
the BUILD 1 study.
Safety and Efficacy Study of Sitaxentan Sodium (Thelin™) in Patients With Pulmonary Arterial Hypertension
Completed
Encysive Pharmaceuticals
Phase 3
2003-05-01
The purpose of this study is to evaluate the safety and efficacy of Thelin™ (sitaxsentan
sodium) compared to placebo (sugar pill) in the treatment of patients with pulmonary arterial
hypertension (PAH).
The objective of the study is to evaluate the effects of chronic TRACLEER® treatment on
testicular function via semen analysis in male patients with primary pulmonary arterial
hypertension (PAH).
Trial of Iloprost Inhaled Solution as Add-On Therapy With Bosentan in Subjects With Pulmonary Arterial Hypertension (PAH)
Completed
Actelion
Phase 2
2004-06-01
The purpose of this study is to determine the safety and efficacy of Iloprost in subjects
that have Pulmonary Arterial Hypertension who are concurrently taking bosentan (Tracleer TM).
Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II
Completed
Actelion
Phase 3
2004-04-01
The present trial investigates a possible use of oral bosentan, which is currently approved
for the treatment of symptoms of pulmonary arterial hypertension (PAH) Class III and IV, to
patients suffering from PAH Class II.
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