Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia)
The purpose of this study is to determine if toremifene citrate is effective and safe in the
prevention of prostate cancer in men who have been diagnosed with high grade prostatic
intraepithelial neoplasia (PIN).
Toremifene Citrate for Prevention of Bone Fractures in Men With Prostate Cancer on Androgen Deprivation Therapy
Androgen deprivation therapy (ADT) treatment for prostate cancer decreases the natural
hormone called testosterone. This type of therapy is very effective for the treatment of
prostate cancer. However, one of the side effects is bone loss or thinning of the bones that
can lead to osteoporosis and an increased risk of bone fractures (breaking of the bones). The
purpose of the study is to determine whether or not the addition of toremifene citrate (the
study drug) to therapy can prevent or decrease the number of bone fractures and to evaluate
its impact on side effects associated with testosterone reduction therapy.
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