You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR TOLCAPONE


✉ Email this page to a colleague

« Back to Dashboard


All Clinical Trials for Tolcapone

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00033059 ↗ Assessment of Potential Interactions Between Cocaine and Tolcapone - 1 Unknown status National Institute on Drug Abuse (NIDA) Phase 1 2001-07-01 The purpose of this study is to assess the potential interactions between intravenous (IV) cocaine and tolcapone.
NCT00044083 ↗ Clinical Trial of Tolcapone for Cognition in Schizophrenia Terminated National Institute of Mental Health (NIMH) Phase 2 2002-08-01 This study will evaluate whether Tolcapone improves cognition in healthy volunteers as well as patients with schizophrenia. Talcapone is a drug that has been FDA approved for Attention Deficit Disorder and allegedly increase the amount of the neurotransmitter dopamine in the frontal cortex of the brain. ...
NCT00548327 ↗ The Effects of Atomoxetine on Cognition and Brain Function Based on Catechol-O-methyltransferase(COMT) Genotype Terminated National Institute of Mental Health (NIMH) Phase 2 2007-10-01 This study will evaluate whether Atomoxetine improves cognition in healthy volunteers as well as patients with schizophrenia. Atomoxetine is a drug that has been Food and Drug Administration (FDA) approved for Attention Deficit Disorder and allegedly increase the amount of the neurotransmitter dopamine in the frontal cortex of the brain.
NCT00604591 ↗ Effects of Tolcapone on Frontotemporal Dementia Completed National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 2011-07-01 This study will test the effects of a medication called tolcapone on cognitive, behavioral, and language problems seen in patients with frontotemporal dementia (FTD). Tolcapone increases the amount of dopamine, a brain chemical that may be lowered in FTD. The study will see if tolcapone can improve thinking, behavior, and language in people with FTD and will look at the effects of the drug on brain activity. Patients with FTD who are between 40 and 85 years of age may be eligible for this study. Participants will be seen as outpatients at the Columbia University Medical Center approximately one a week for 4 weeks. They take tolcapone or a placebo (a look-alike pill with no active ingredient) during study week 1. During study week 3, those who took placebo during week 1 now take tolcapone for 1 week and those who took tolcapone now take placebo. In addition, patients undergo the following tests and procedures: - Neurological tests to evaluate attention, problem-solving and memory. These tests are repeated several times during the course of the study. - Test to look for a gene that affects the amount of dopamine in the brain, using blood samples collected in a previous study. - Blood draws four times during the study. - Functional MRI (fMRI) to learn about changes in brain regions that are involved in performing tasks. For fMRI, the patient lies on a table that can slide in and out of the scanner, a narrow metal cylinder surrounded by a magnetic field. The procedure takes about 60 minutes and is performed four times over the course of the . FMRI involves taking pictures of the brain during MRI while the subject performs a task so that changes in the brain that occur during these tasks can be studied.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Tolcapone

Condition Name

Condition Name for Tolcapone
Intervention Trials
Impulsive Behavior 2
Pathological Gambling 2
Schizophrenia 2
Nicotine Dependence 2
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Condition MeSH

Condition MeSH for Tolcapone
Intervention Trials
Tobacco Use Disorder 3
Disease 3
Alcoholism 3
Impulsive Behavior 2
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Locations for Tolcapone

Trials by Country

Trials by Country for Tolcapone
Location Trials
United States 28
Germany 1
Switzerland 1
Sweden 1
United Kingdom 1
This preview shows a limited data set
Subscribe for full access, or try a Trial

Trials by US State

Trials by US State for Tolcapone
Location Trials
California 7
Maryland 3
South Carolina 3
Pennsylvania 3
Connecticut 2
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Progress for Tolcapone

Clinical Trial Phase

Clinical Trial Phase for Tolcapone
Clinical Trial Phase Trials
Phase 4 3
Phase 2/Phase 3 1
Phase 2 11
[disabled in preview] 4
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Status

Clinical Trial Status for Tolcapone
Clinical Trial Phase Trials
Completed 17
Terminated 3
Recruiting 2
[disabled in preview] 2
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Sponsors for Tolcapone

Sponsor Name

Sponsor Name for Tolcapone
Sponsor Trials
University of California, San Francisco 7
University of California, Berkeley 5
National Institute on Drug Abuse (NIDA) 3
[disabled in preview] 3
This preview shows a limited data set
Subscribe for full access, or try a Trial

Sponsor Type

Sponsor Type for Tolcapone
Sponsor Trials
Other 34
NIH 8
U.S. Fed 4
[disabled in preview] 4
This preview shows a limited data set
Subscribe for full access, or try a Trial

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.