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Last Updated: January 25, 2020

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CLINICAL TRIALS PROFILE FOR TIVICAY

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All Clinical Trials for Tivicay

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00537966 Characterization of Acute and Recent HIV-1 Infections in Zurich: a Long-term Observational Study Recruiting University of Zurich N/A 2002-01-01 Aim of the study: To describe the epidemiology, longitudinally follow, test the effect of early antiretroviral treatment and investigate early events of virus-host interactions in patients with documented acute or recent HIV-1 infection in Zurich. Study design: This is an open label, non-randomized, observational, single center study at the University Hospital Zurich, Division of Infectious Diseases and Hospital Epidemiology. We aim at enrolling approximately 300 patients over a 10 year period. All patients who fulfill the inclusion criteria of a documented acute or recent HIV infection can participate in the study. Patients are offered early combination antiretroviral treatment (cART), if treatment start falls within 90 days after diagnosis of acute HIV-infection. After one year of suppressed HIV-plasma viremia (< 50 copies/ml) patients can chose to stop cART. Patients who have not chosen to undergo early-cART, respectively will stop cART after one year will be followed for a total of 5 years. Viral setpoints reached after treatment interruptions will be compared to historic controls and to the control group not having received cART during acute infection. A battery of virological and immunological assays will be performed on blood samples obtained to better understand early virus-host interactions, which are thought to play a key role in HIV-pathogenesis research. Summary: In summary, this study will provide comprehensive knowledge on early HIV-infection with regard to epidemiology, impact of early-cART on the course of disease and forms the base for a variety of translational research projects addressing early key pathogenesis events between virus and host, relevant for the course of disease, for transmission, for development of vaccines and new treatment strategies. - Trial with medicinal product
NCT02098837 Cardiovascular Risk in HIV Patients Switching From a Boosted Protease Inhibitor (PI) to Dolutegravir (DTG) Active, not recruiting St Stephens Aids Trust Phase 4 2014-04-01 The purpose of the study is to investigate the benefits of switching away from a kind of drug called a boosted protease inhibitor (PI) to a new drug called dolutegravir on patients' cardiovascular health (the health of their hearts). Patients are currently taking two other anti-HIV drugs, called nucleoside reverse transcriptase inhibitors (NRTIs), with their boosted PIs; these NRTIs will not be changed throughout the study. In order to compare the boosted PI and dolutegravir more accurately, half of study participants will be switched to dolutegravir immediately, and the other half will be switched after 48 weeks of continuing on the boosted PI. Boosted PIs are associated with increased heart and circulation risk so it is hoped that switching from a boosted PI to dolutegravir will improve the health of the patients' hearts. Dolutegravir is a drug for HIV treatment which has been approved for use in HIV patients in the US and Europe. Clinical trials using dolutegravir have found that it is effective at suppressing the HIV virus, and it is at least as effective as the other drugs. This study will also investigate the safety (in terms of other side effects and the routine blood tests which the investigators ordinarily use to monitor patients' treatment) and monitor effectiveness, patients' viral load and CD4 counts, when patients switch treatment from a boosted PI to dolutegravir. Viral load is the amount of the HIV virus they have in their blood, and CD4 count is a measure of a type of cell that is in their immune system. We also aim to improve patients' cardiovascular health in general by providing them with information on how to live a healthy lifestyle (eg improving their diet, stopping smoking etc).
NCT02351908 Renal Integrase Study Active, not recruiting Merck Sharp & Dohme Corp. Phase 4 2015-03-01 The purpose of this study is to observe the safety of Truvada® (TDF/FTC) in relation to its impact on kidney function combined with different Integrase Inhibitors (Dolutegravir, or Elvitegravir/Cobicistat or Raltegravir), when given to patients who are commencing treatment for HIV infection for the first time. All three combinations (Raltegravir + Truvada®, Dolutegravir + Truvada® and Stribild®, a single pill which contains Elvitegravir/Cobicistat/Truvada®) are currently recommended by the national guide-lines and used in standard clinical practice.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Tivicay

Condition Name

Condition Name for Tivicay
Intervention Trials
HIV 7
HIV-1 Infection 5
HIV Infections 2
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Condition MeSH

Condition MeSH for Tivicay
Intervention Trials
HIV Infections 9
Acquired Immunodeficiency Syndrome 6
Infection 5
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Clinical Trial Locations for Tivicay

Trials by Country

Trials by Country for Tivicay
Location Trials
United States 21
Argentina 4
Germany 3
United Kingdom 3
France 3
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Trials by US State

Trials by US State for Tivicay
Location Trials
California 3
Georgia 2
Colorado 2
Texas 2
North Carolina 2
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Clinical Trial Progress for Tivicay

Clinical Trial Phase

Clinical Trial Phase for Tivicay
Clinical Trial Phase Trials
Phase 4 7
Phase 3 4
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Tivicay
Clinical Trial Phase Trials
Recruiting 10
Active, not recruiting 5
Not yet recruiting 4
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Clinical Trial Sponsors for Tivicay

Sponsor Name

Sponsor Name for Tivicay
Sponsor Trials
ViiV Healthcare 7
National Institute of Allergy and Infectious Diseases (NIAID) 3
St Stephens Aids Trust 3
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Sponsor Type

Sponsor Type for Tivicay
Sponsor Trials
Other 27
Industry 13
NIH 4
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