To assess the safety and efficacy of a cohort of patients switched to the
dorzolamide/timolol maleate fixed combination because they are insufficiently controlled on
latanoprost monotherapy.
To compare the intraocular pressure efficacy and safety of the DTFC given twice daily versus
the LTFC given once every morning following a run-in period with timolol maleate given twice
daily.
24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients
Completed
Aristotle University Of Thessaloniki
Phase 4
2006-04-01
The purpose of this study is to compare the short-term mean 24-hour intraocular pressure
control, 24-hour blood pressure effect and safety of Latanoprost/Timolol fixed combination
given once in the evening with placebo once in the morning versus timolol maleate 0.5% given
twice daily in patients with ocular hypertension and primary open-angle glaucoma.
INFLUENCE OF TOPICAL INDOMETHACIN ON HYPOTHENSIVE EFFECT OF BRIMONIDINE
Terminated
Federal University of São Paulo
Phase 4
1969-12-31
Purpose:
To evaluate the influence of the nonsteroidal anti-inflammatory indomethacin on the
brimonidine intraocular pressure (IOP) lowering effect.
Methods:
A randomized double-masked study was carried out. Patients medicated with timolol maleate
0,5% and needed complementary medication were random allocated into two groups: (a)
brimonidine tartarate 0,15% and indomethacin 1% or (b) brimonidine tartarate and placebo
(balanced saline solution). If patient’s both eyes were eligible, they were allocated to the
same group.
IOP was measured at two weeks, one month and two months after study beginning. The mean IOP
of the eyes was used for analyzes, in the case of two eligible eyes. For statistical
analyzes repeated measures analysis was used.
Serving leading biopharmaceutical companies globally:
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.
The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.
thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.
Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
Alerts Available With Subscription
Alerts are available for users with active subscriptions.
