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CLINICAL TRIALS PROFILE FOR TIMOLOL MALEATE

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All Clinical Trials for Timolol Maleate

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00108017	Comparison of the Effects of Two Glaucoma Drugs Over 24 Hours (0507A-137)(COMPLETED)	Completed	Merck Sharp & Dohme Corp.	Phase 3	2005-04-01	This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.
NCT00273442	Assessing Cosopt Switch Patients	Completed	Pharmaceutical Research Network	Phase 4	2005-11-01	To assess the safety and efficacy of a cohort of patients switched to the dorzolamide/timolol maleate fixed combination because they are insufficiently controlled on latanoprost monotherapy.
NCT00273481	Cosopt Versus Xalacom	Completed	Pharmaceutical Research Network	Phase 4	2005-09-01	To compare the intraocular pressure efficacy and safety of the DTFC given twice daily versus the LTFC given once every morning following a run-in period with timolol maleate given twice daily.
NCT00330577	24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients	Completed	Aristotle University Of Thessaloniki	Phase 4	2006-04-01	The purpose of this study is to compare the short-term mean 24-hour intraocular pressure control, 24-hour blood pressure effect and safety of Latanoprost/Timolol fixed combination given once in the evening with placebo once in the morning versus timolol maleate 0.5% given twice daily in patients with ocular hypertension and primary open-angle glaucoma.
NCT00347035	INFLUENCE OF TOPICAL INDOMETHACIN ON HYPOTHENSIVE EFFECT OF BRIMONIDINE	Terminated	Federal University of São Paulo	Phase 4	1969-12-31	Purpose: To evaluate the influence of the nonsteroidal anti-inflammatory indomethacin on the brimonidine intraocular pressure (IOP) lowering effect. Methods: A randomized double-masked study was carried out. Patients medicated with timolol maleate 0,5% and needed complementary medication were random allocated into two groups: (a) brimonidine tartarate 0,15% and indomethacin 1% or (b) brimonidine tartarate and placebo (balanced saline solution). If patient’s both eyes were eligible, they were allocated to the same group. IOP was measured at two weeks, one month and two months after study beginning. The mean IOP of the eyes was used for analyzes, in the case of two eligible eyes. For statistical analyzes repeated measures analysis was used.
NCT00372827	Study of Brinzolamide and Timolol When Added to Travoprost in Primary Open-angle Glaucoma or Ocular Hypertension	Completed	Alcon Research	Phase 4	2004-02-01	The purpose of the study is to compare the efficacy and safety of Timolol 0.5% solution to Brinzolamide 1% each given twice daily when added to Travoprost 0.004% given each evening.

Clinical Trial Conditions for Timolol Maleate

Condition Name

Condition Name for Timolol Maleate
Intervention	Trials
Ocular Hypertension	33
Glaucoma	18
Open-Angle Glaucoma	15
Glaucoma, Open-Angle	4

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Condition MeSH

Condition MeSH for Timolol Maleate
Intervention	Trials
Glaucoma	39
Ocular Hypertension	38
Glaucoma, Open-Angle	33
Hypertension	31

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Clinical Trial Locations for Timolol Maleate

Trials by Country

Trials by Country for Timolol Maleate
Location	Trials
United States	86
Spain	6
Germany	4
Canada	4
France	2

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Trials by US State

Trials by US State for Timolol Maleate
Location	Trials
California	10
New York	6
Georgia	5
New Jersey	5
Tennessee	4

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Clinical Trial Progress for Timolol Maleate

Clinical Trial Phase

Clinical Trial Phase for Timolol Maleate
Clinical Trial Phase	Trials
Phase 4	21
Phase 3	15
Phase 2	10

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Clinical Trial Status

Clinical Trial Status for Timolol Maleate
Clinical Trial Phase	Trials
Completed	35
Recruiting	11
Active, not recruiting	3

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Clinical Trial Sponsors for Timolol Maleate

Sponsor Name

Sponsor Name for Timolol Maleate
Sponsor	Trials
Alcon Research	8
Allergan	5
Aerie Pharmaceuticals	5

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Sponsor Type

Sponsor Type for Timolol Maleate
Sponsor	Trials
Industry	42
Other	22

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