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Generated: December 16, 2018

DrugPatentWatch Database Preview

CLINICAL TRIALS PROFILE FOR TIMOLOL

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Clinical Trials for Timolol

Trial ID Title Status Sponsor Phase Summary
NCT00004641 A Study to Prevent Complications of High Blood Pressure Caused by Hepatitis in Patients With Cirrhosis Completed Yale University Phase 2 OBJECTIVES: I. Evaluate the efficacy of a certain drug in preventing intestinal complications in patients with cirrhosis and high blood pressure in the hepatic portal vein. II. Evaluate vein pressure measurements to predict the development of internal bleeding.
NCT00004641 A Study to Prevent Complications of High Blood Pressure Caused by Hepatitis in Patients With Cirrhosis Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 2 OBJECTIVES: I. Evaluate the efficacy of a certain drug in preventing intestinal complications in patients with cirrhosis and high blood pressure in the hepatic portal vein. II. Evaluate vein pressure measurements to predict the development of internal bleeding.
NCT00006398 Prevention of Esophageal Varices by Beta-Adrenergic Blockers Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Phase 3 The purpose of this study is to learn whether timolol is useful in preventing or delaying the appearance of gastroesophageal varices, a complication that may develop in the future as a consequence of liver disease. Cirrhosis causes an increased resistance of blood flowing through the liver. This leads to an increased pressure in the portal vein (the vein that takes blood to your liver). High portal pressure is responsible for the appearance of complications of chronic liver disease such as varices and variceal bleeding (bleeding from veins in your esophagus). Timolol belongs to a group of medications called beta-blockers. Beta-blockers decrease high portal pressure and previous studies have shown that beta-blocker pills are useful in preventing bleeding from varices in patients who already have varices. A more desirable effect would be if these pills could prevent not only bleeding from varices but the appearance of varices (and therefore of bleeding).
NCT00007592 Hypertension Screening and Treatment Program Completed VA Office of Research and Development N/A Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.
NCT00061542 Safety and Efficacy Study of BETOPTIC S 0.25% and Timolol Gel-forming Solution 0.25% and 0.5% in Pediatric Patients With Glaucoma or Ocular Hypertension Completed Alcon Research Phase 3 The purpose of this study is to evaluate the safety and efficacy of BETOPTIC S and Timolol Gel-forming solution in pediatric patients. Patients will dose with study drug at 8 am and 8 pm daily for twelve weeks. Patients will have vision tested, slit lamp exam, blood pressure and pulse checks at each visit. Patients will have a dilated fundus exam and corneal measurements taken at first and last visit.
NCT00108017 Comparison of the Effects of Two Glaucoma Drugs Over 24 Hours (0507A-137)(COMPLETED) Completed Merck Sharp & Dohme Corp. Phase 3 This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Timolol

Condition Name

Condition Name for Timolol
Intervention Trials
Ocular Hypertension 107
Glaucoma 67
Open-angle Glaucoma 38
Glaucoma, Open-Angle 17
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Condition MeSH

Condition MeSH for Timolol
Intervention Trials
Glaucoma 141
Ocular Hypertension 119
Hypertension 106
Glaucoma, Open-Angle 98
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Clinical Trial Locations for Timolol

Trials by Country

Trials by Country for Timolol
Location Trials
United States 295
Italy 22
Canada 21
Germany 20
Spain 14
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Trials by US State

Trials by US State for Timolol
Location Trials
California 27
Texas 20
Pennsylvania 17
Florida 15
New York 14
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Clinical Trial Progress for Timolol

Clinical Trial Phase

Clinical Trial Phase for Timolol
Clinical Trial Phase Trials
Phase 4 74
Phase 3 68
Phase 2/Phase 3 4
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Clinical Trial Status

Clinical Trial Status for Timolol
Clinical Trial Phase Trials
Completed 145
Recruiting 23
Unknown status 13
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Clinical Trial Sponsors for Timolol

Sponsor Name

Sponsor Name for Timolol
Sponsor Trials
Alcon Research 37
Allergan 35
Pfizer 14
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Sponsor Type

Sponsor Type for Timolol
Sponsor Trials
Industry 145
Other 91
NIH 3
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McKinsey
Argus Health
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Johnson and Johnson
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McKesson
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