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Generated: March 23, 2019

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CLINICAL TRIALS PROFILE FOR TETRACYCLINE HYDROCHLORIDE

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Clinical Trials for Tetracycline Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00000120 Clinical Trial of Eye Prophylaxis in the Newborn Completed National Eye Institute (NEI) Phase 3 To compare the effectiveness of silver nitrate drops, erythromycin ointment, or no medication in preventing neonatal conjunctivitis caused by Chlamydia trachomatis and other eye infections. To compare side effects of the two prophylactic agents.
NCT00001683 A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer Completed National Cancer Institute (NCI) Phase 1 Matrix metalloproteinases (MMPs) are a class of membrane bound enzymes that are involved in the degradation of the extracellular matrix. MMP-2 and MMP-9 have been associated with the progression of cancer. It is hypothesized than an imbalance between MMPs and MMP inhibitors allows the destruction of the extracellular matrix and enhances the ability of the tumor cells to grow and metastasize. By inhibiting MMPs, it is thought that angiogenesis and metastasis can be inhibited. This is a phase I study of COL-3, an oral matrix metalloproteinase inhibitor, in patients with refractory metastatic cancer. COL-3 is a chemically modified tetracycline derivative. Patients must have clinically progressive disease documented within 1 month prior to entry to be eligible for treatment. Patients must have also failed therapy of proven efficacy for their disease and have an ECOG performance status of less or equal than 2. Patients must be willing to travel from their home to the NIH for follow-up visits. Patients with brain metastases or primary CNS malignancies are not eligible. Concurrent therapy for their cancer (i.e., radiation therapy, chemotherapy, etc.) will preclude participation. We will be defining the maximum tolerated dose, the toxicity profile, characterizing the pharmacokinetics, and evaluating the effect of COL-3 on several biological endpoints.
NCT00002682 Antibiotic Therapy and Antacids in Patients With Malt Lymphoma of the Stomach Completed National Cancer Institute (NCI) Phase 2 RATIONALE: Antibiotic therapy and antacids are used to treat Helicobacter pylori infection of the stomach. These treatments may also have an effect on gastric MALT lymphoma of the stomach. PURPOSE: Phase II trial to study the effectiveness of antibiotic therapy with amoxicillin, clarithromycin, tetracycline, and metronidazole plus antacids in patients with MALT lymphoma of the stomach.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Tetracycline Hydrochloride

Condition Name

Condition Name for Tetracycline Hydrochloride
Intervention Trials
Helicobacter Pylori Infection 27
Schizophrenia 5
Helicobacter Infection 3
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Condition MeSH

Condition MeSH for Tetracycline Hydrochloride
Intervention Trials
Helicobacter Infections 35
Infection 23
Communicable Diseases 15
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Clinical Trial Locations for Tetracycline Hydrochloride

Trials by Country

Trials by Country for Tetracycline Hydrochloride
Location Trials
United States 139
Taiwan 20
China 11
United Kingdom 8
Canada 8
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Trials by US State

Trials by US State for Tetracycline Hydrochloride
Location Trials
California 14
Texas 9
Ohio 8
Massachusetts 7
New York 6
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Clinical Trial Progress for Tetracycline Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Tetracycline Hydrochloride
Clinical Trial Phase Trials
Phase 4 49
Phase 3 27
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for Tetracycline Hydrochloride
Clinical Trial Phase Trials
Completed 62
Recruiting 36
Unknown status 20
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Clinical Trial Sponsors for Tetracycline Hydrochloride

Sponsor Name

Sponsor Name for Tetracycline Hydrochloride
Sponsor Trials
National Taiwan University Hospital 10
National Eye Institute (NEI) 6
Shanghai Jiao Tong University School of Medicine 5
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Sponsor Type

Sponsor Type for Tetracycline Hydrochloride
Sponsor Trials
Other 208
Industry 27
NIH 15
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