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Generated: June 26, 2019

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CLINICAL TRIALS PROFILE FOR TEPADINA

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Clinical Trials for Tepadina

Trial ID Title Status Sponsor Phase Summary
NCT01148173 High-dose Chemotherapy and Stem Cell Transplantation for Central Nervous System (CNS) Relapse of Aggressive Lymphomas Unknown status Charite University, Berlin, Germany Phase 2 Central nervous system (CNS) relapses of aggressive lymphomas are a rare but devastating complication. There is no therapy standard, conventional approaches are palliative. This study investigates an intensive chemotherapy with CNS penetrating drugs followed by high-dose chemotherapy and autologous stem cell transplantation as a potentially curative approach.
NCT01810926 T&B Depletion Non Malignant Unknown status Fresenius AG Phase 2 • The primary aim of the present trial is to assess in a randomized fashion the benefit on standard graft-versus-host disease (GVHD) prophylaxis of the addition of ATG-Fresenius S ® in transplants from matched related donors (MRD) and of anti-CD20 rituximab in transplants from matched unrelated donors (MUD). Both safety and efficacy of the treatment will be assessed, in particular in respect to the clinical status of the patient, i.e. prevention of graft failure and chronic GvHD and of Ebstein Barr virus (EBV) viremia for MUD patients. The conditioning proposed combines myeloablative drugs with a favorable safety profile such as treosulfan, thiotepa (Tepadina®) and fludarabine with the intent to reduce the traditional immediate and late toxicity of busulfan and cyclophosphamide.
NCT01810926 T&B Depletion Non Malignant Unknown status medac GmbH Phase 2 • The primary aim of the present trial is to assess in a randomized fashion the benefit on standard graft-versus-host disease (GVHD) prophylaxis of the addition of ATG-Fresenius S ® in transplants from matched related donors (MRD) and of anti-CD20 rituximab in transplants from matched unrelated donors (MUD). Both safety and efficacy of the treatment will be assessed, in particular in respect to the clinical status of the patient, i.e. prevention of graft failure and chronic GvHD and of Ebstein Barr virus (EBV) viremia for MUD patients. The conditioning proposed combines myeloablative drugs with a favorable safety profile such as treosulfan, thiotepa (Tepadina®) and fludarabine with the intent to reduce the traditional immediate and late toxicity of busulfan and cyclophosphamide.
NCT01810926 T&B Depletion Non Malignant Unknown status University of Milano Bicocca Phase 2 • The primary aim of the present trial is to assess in a randomized fashion the benefit on standard graft-versus-host disease (GVHD) prophylaxis of the addition of ATG-Fresenius S ® in transplants from matched related donors (MRD) and of anti-CD20 rituximab in transplants from matched unrelated donors (MUD). Both safety and efficacy of the treatment will be assessed, in particular in respect to the clinical status of the patient, i.e. prevention of graft failure and chronic GvHD and of Ebstein Barr virus (EBV) viremia for MUD patients. The conditioning proposed combines myeloablative drugs with a favorable safety profile such as treosulfan, thiotepa (Tepadina®) and fludarabine with the intent to reduce the traditional immediate and late toxicity of busulfan and cyclophosphamide.
NCT01810926 T&B Depletion Non Malignant Unknown status Franco Locatelli Phase 2 • The primary aim of the present trial is to assess in a randomized fashion the benefit on standard graft-versus-host disease (GVHD) prophylaxis of the addition of ATG-Fresenius S ® in transplants from matched related donors (MRD) and of anti-CD20 rituximab in transplants from matched unrelated donors (MUD). Both safety and efficacy of the treatment will be assessed, in particular in respect to the clinical status of the patient, i.e. prevention of graft failure and chronic GvHD and of Ebstein Barr virus (EBV) viremia for MUD patients. The conditioning proposed combines myeloablative drugs with a favorable safety profile such as treosulfan, thiotepa (Tepadina®) and fludarabine with the intent to reduce the traditional immediate and late toxicity of busulfan and cyclophosphamide.
NCT03126916 Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma Not yet recruiting National Cancer Institute (NCI) Phase 3 This partially randomized phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving iobenguane I-131 or crizotinib and standard therapy may work better in treating younger patients with neuroblastoma or ganglioneuroblastoma.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Tepadina

Condition Name

Condition Name for Tepadina
Intervention Trials
NMYC Gene Amplification 2
Childhood Ganglioneuroblastoma 1
Lymphoma, Non-Hodgkin 1
Acute Leukemia of Ambiguous Lineage 1
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Condition MeSH

Condition MeSH for Tepadina
Intervention Trials
Neuroblastoma 2
Ganglioneuroblastoma 2
Graft vs Host Disease 2
Preleukemia 1
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Clinical Trial Locations for Tepadina

Trials by Country

Trials by Country for Tepadina
Location Trials
United States 10
Italy 1
Germany 1
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Trials by US State

Trials by US State for Tepadina
Location Trials
Ohio 2
Pennsylvania 2
Washington 1
Massachusetts 1
Iowa 1
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Clinical Trial Progress for Tepadina

Clinical Trial Phase

Clinical Trial Phase for Tepadina
Clinical Trial Phase Trials
Phase 3 1
Phase 2 5
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Clinical Trial Status

Clinical Trial Status for Tepadina
Clinical Trial Phase Trials
Not yet recruiting 4
Unknown status 2
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Clinical Trial Sponsors for Tepadina

Sponsor Name

Sponsor Name for Tepadina
Sponsor Trials
National Cancer Institute (NCI) 3
medac GmbH 1
Fred Hutchinson Cancer Research Center 1
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Sponsor Type

Sponsor Type for Tepadina
Sponsor Trials
Other 6
NIH 3
Industry 2
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