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Last Updated: March 26, 2025

CLINICAL TRIALS PROFILE FOR TECHNETIUM TC 99M MPI MDP


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505(b)(2) Clinical Trials for Technetium Tc 99m Mpi Mdp

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Combination NCT03906045 ↗ A Scintigraphy Study of PT010 in COPD Patients Completed Simbec Research Phase 1 2019-04-04 This study is a single treatment period, single dose gamma scintigraphy study investigating the deposition in the lungs of a Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dose Inhaler (BGF-MDI). This study will be investigating how the drug (known as PT010) is distributed in the lungs of Chronic Obstructive Pulmonary Disease (COPD) patients (with moderate to very severe COPD) following a maximal 10 second breath hold. This inhaler is intended to be used in the treatment of COPD, which is a group of diseases which cause lung problems and difficulty breathing. PT010 is a new combination product of 3 marketed drugs called Glycopyrronium, Formoterol Fumarate and Budesonide.
New Combination NCT03906045 ↗ A Scintigraphy Study of PT010 in COPD Patients Completed AstraZeneca Phase 1 2019-04-04 This study is a single treatment period, single dose gamma scintigraphy study investigating the deposition in the lungs of a Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dose Inhaler (BGF-MDI). This study will be investigating how the drug (known as PT010) is distributed in the lungs of Chronic Obstructive Pulmonary Disease (COPD) patients (with moderate to very severe COPD) following a maximal 10 second breath hold. This inhaler is intended to be used in the treatment of COPD, which is a group of diseases which cause lung problems and difficulty breathing. PT010 is a new combination product of 3 marketed drugs called Glycopyrronium, Formoterol Fumarate and Budesonide.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Technetium Tc 99m Mpi Mdp

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00001003 ↗ A Study of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1969-12-31 To evaluate and compare 3 anti-pneumocystis regimens plus zidovudine (AZT) in persons with advanced HIV disease and T4 cell count < 200 cells/mm3. To establish the range of pentamidine (PEN) deposition in AIDS patients participating in ACTG 021 and ACTG 081. To identify factors (breathing pattern, pulmonary function) that may be important in affecting the actual dose delivered to a given patient. The specific system that is used to deliver PEN to the lungs may determine whether a therapeutically effective dose is attained in the lungs. Therefore, this study will establish the amount of PEN that is deposited in the lungs of patients enrolled in protocols ACTG 021 and ACTG 081, who are being treated with PEN administered from the Marquest Respirgard II nebulizer.
NCT00001277 ↗ Studies of Elevated Parathyroid Activity Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1993-12-15 Patients whose parathyroid activity is elevated above normal are referred to as having hyperparathyroidism. This study will help researchers better understand the causes of hyperthyroidism and to evaluate and improve methods for diagnosis and treatment. In this study, patients diagnosed with or suspected of having hyperparathyroidism will be selected to participate. In addition, patients with related conditions such as parathyroid tumors, will also be selected. Subjects will be asked to provide blood and urine for testing to confirm their condition. They will then be surgically treated by removal of the parathyroid gland(s) (parathyroidectomy). Subjects with parathyroid tumors will undergo several diagnostic tests to determine the exact location of the tumor as well as the tumor's activity. The tests may include; ultrasounds, nuclear scanning, CT scans, MRI, and specialized blood testing. Sometimes parathyroidectomy leads to hypoparathyroidism. Options for treating the patients after the surgical procedure will also be addressed. Calcium and Vitamin D supplements are typically the mainstay of post parathyroidectomy therapy. Other potential treatments include transplanting the parathyroid gland(s) to other areas of the body.
NCT00003654 ↗ Diagnostic Study to Identify Sentinel Lymph Nodes in Women With Stage I or Stage II Breast Cancer Terminated UNICANCER N/A 1997-09-01 RATIONALE: Diagnostic procedures, such as blue dye or imaging to identify sentinel lymph nodes, may improve the ability to detect the extent of disease and help plan effective surgery for removing breast tumors. PURPOSE: Diagnostic trial to study the effectiveness of blue dye and an imaging procedure to identify the sentinel lymph node under the arm in women with stage I or stage II breast cancer.
NCT00004705 ↗ Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis Completed University of North Carolina N/A 1996-09-01 OBJECTIVES: I. Determine the stability of uridine triphosphate (UTP) and examine the metabolism of exogenous nucleotides on airway epithelial surfaces in patients with cystic fibrosis. II. Determine the acute safety and efficacy of aerosolized UTP in children with cystic fibrosis.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Technetium Tc 99m Mpi Mdp

Condition Name

Condition Name for Technetium Tc 99m Mpi Mdp
Intervention Trials
Breast Cancer 14
Healthy 4
Melanoma 4
Prostate Cancer 3
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Condition MeSH

Condition MeSH for Technetium Tc 99m Mpi Mdp
Intervention Trials
Breast Neoplasms 18
Carcinoma 13
Prostatic Neoplasms 11
Neoplasms 7
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Clinical Trial Locations for Technetium Tc 99m Mpi Mdp

Trials by Country

Trials by Country for Technetium Tc 99m Mpi Mdp
Location Trials
United States 223
Canada 26
United Kingdom 15
China 11
Italy 9
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Trials by US State

Trials by US State for Technetium Tc 99m Mpi Mdp
Location Trials
California 16
Texas 15
Washington 13
Pennsylvania 12
New York 12
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Clinical Trial Progress for Technetium Tc 99m Mpi Mdp

Clinical Trial Phase

Clinical Trial Phase for Technetium Tc 99m Mpi Mdp
Clinical Trial Phase Trials
Phase 4 7
Phase 3 15
Phase 2/Phase 3 1
[disabled in preview] 31
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Clinical Trial Status

Clinical Trial Status for Technetium Tc 99m Mpi Mdp
Clinical Trial Phase Trials
Completed 67
Recruiting 20
Terminated 15
[disabled in preview] 6
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Clinical Trial Sponsors for Technetium Tc 99m Mpi Mdp

Sponsor Name

Sponsor Name for Technetium Tc 99m Mpi Mdp
Sponsor Trials
National Cancer Institute (NCI) 20
Endocyte 9
Mayo Clinic 8
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Sponsor Type

Sponsor Type for Technetium Tc 99m Mpi Mdp
Sponsor Trials
Other 117
Industry 67
NIH 33
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Technetium-99m: A Cornerstone in Medical Imaging

Introduction to Technetium-99m

Technetium-99m (Tc-99m) is a radiopharmaceutical that has revolutionized the field of nuclear medicine. Its versatility, safety, and efficacy make it a pivotal tool in various diagnostic imaging procedures, including cardiovascular, bone, and renal imaging.

Clinical Applications of Technetium-99m

Bone Scans and Oncology

Tc-99m is widely used in bone scans, particularly with the radiopharmaceutical Tc-99m Methylene Diphosphonate (MDP). This compound has a high affinity for bone tissues, making it highly effective in detecting bone metastases, fractures, and bone infections like osteomyelitis[1].

Myocardial Perfusion Imaging

In cardiovascular imaging, Tc-99m plays a crucial role in myocardial perfusion imaging (MPI), which visualizes blood flow through the heart muscle. Radiopharmaceuticals like Tc-99m Sestamibi and Tc-99m Tetrofosmin are absorbed by healthy heart muscle cells, providing vital insights into cardiac health[1].

Renal Imaging

Tc-99m-based radiopharmaceuticals, such as Tc-99m mercaptoacetyltriglycine (MAG3) and Tc-99m dimercaptosuccinic acid (DMSA), are essential in assessing kidney function and morphology. These agents help in diagnosing and managing renal diseases, including renal artery stenosis and obstructive uropathy[1].

Current Clinical Trials

Several clinical trials are underway to further explore the potential of Tc-99m radiopharmaceuticals:

Molecular Imaging of Prostate-Specific Membrane Antigen

A Phase 1 trial conducted by the Tomsk National Research Medical Center and Uppsala University is evaluating the biological distribution of [99mTc]Tc-BQ0413 in patients with prostate cancer. This trial aims to assess the distribution in normal tissues and tumors, dosimetry, and safety after a single injection[1].

Molecular Imaging of Gastrin Releasing Peptide Receptors

Another Phase 1 trial by the same institutions is investigating the distribution of 99mTc-DB8 in patients with prostate and breast cancer. This study compares SPECT imaging results with CT, MRI, ultrasound, and immunohistochemical studies[1].

Market Analysis and Projections

Market Size and Growth

The Technetium-99m market is expected to grow significantly, driven by the rising demand for Tc-99m-based radiopharmaceuticals. By 2030, the market is projected to reach nearly USD 6.54 billion, growing at a CAGR of 4.05% from 2024 to 2030[2].

Regional Outlook

North America, particularly the United States, leads the global market due to its advanced healthcare infrastructure and high prevalence of chronic diseases. Europe and the Asia-Pacific region are also significant markets, with countries like Japan, China, and India experiencing rapid growth in medical imaging[2][4].

Application Segmentation

The cardiovascular segment holds the largest market share, primarily due to the critical role of Tc-99m in myocardial perfusion imaging. Other significant applications include bone scans, respiratory imaging, and tumor imaging[2][4].

Technological Advancements and Market Drivers

New Radiopharmaceutical Developments

Ongoing research and development are focused on creating new Tc-99m-based radiopharmaceuticals with improved specificity and sensitivity. These advancements are expected to increase the utility of Tc-99m in a wider range of clinical applications, driving market growth[2].

Production Improvements

Technological improvements in radiopharmaceutical production, such as more efficient cyclotron-based methods, are addressing supply challenges and ensuring a steady supply of high-quality Tc-99m. This enhances the quality and cost-effectiveness of Tc-99m, further driving market demand[4].

Collaborations and Mergers

The market is characterized by increasing collaborations and mergers aimed at enhancing product portfolios, improving supply chains, and investing in next-generation radiopharmaceuticals. These collaborations are expected to drive market growth by ensuring the availability of high-quality Tc-99m and expanding its applications[4].

Future Outlook

The Technetium-99m market is set to continue growing due to its essential role in diagnosing chronic and non-communicable diseases, advancements in imaging technology, and a global healthcare system that increasingly relies on early detection methods. By 2034, the market is projected to exceed USD 8.6 billion, solidifying Tc-99m's position as a vital diagnostic tool in the global healthcare landscape[4].

Key Takeaways

  • Versatile Applications: Tc-99m is used in various diagnostic imaging procedures, including bone scans, myocardial perfusion imaging, and renal imaging.
  • Market Growth: The Tc-99m market is expected to grow at a CAGR of 4.05% from 2024 to 2030, reaching nearly USD 6.54 billion.
  • Regional Dominance: North America, particularly the United States, leads the global market, followed by Europe and the Asia-Pacific region.
  • Technological Advancements: Ongoing research and development are focused on creating new Tc-99m-based radiopharmaceuticals with improved specificity and sensitivity.
  • Future Projections: By 2034, the market is projected to exceed USD 8.6 billion, driven by advancements in imaging technology and growing healthcare demands.

FAQs

What is the primary use of Technetium-99m in medical imaging?

Technetium-99m is primarily used in various diagnostic imaging procedures, including bone scans, myocardial perfusion imaging, and renal imaging, due to its ability to form diverse radiopharmaceuticals targeting specific organs or functions.

Which region dominates the Technetium-99m market?

North America, particularly the United States, dominates the global Technetium-99m market due to its advanced healthcare infrastructure and high prevalence of chronic diseases.

What drives the growth of the Technetium-99m market?

The growth of the Technetium-99m market is driven by the rising demand for Tc-99m-based radiopharmaceuticals, advancements in medical imaging technologies, and ongoing research and development of new radiopharmaceuticals.

What are the key applications of Technetium-99m in clinical practice?

Key applications include cardiovascular imaging (myocardial perfusion imaging), bone scans (detecting bone metastases and fractures), and renal imaging (assessing kidney function and morphology).

What are the future projections for the Technetium-99m market?

By 2034, the Technetium-99m market is projected to exceed USD 8.6 billion, driven by advancements in imaging technology and growing healthcare demands for early detection and non-invasive diagnostic procedures.

Sources

  1. OpenMedScience: Technetium-99m Radiopharmaceuticals in Advanced Medical Imaging
  2. Maximize Market Research: Technetium-99m Market: Industry Analysis and Forecast 2030
  3. IAEA: New CRP to Develop new Technetium-99m Radiopharmaceuticals for Disease Diagnosis
  4. GlobeNewswire: Technetium-99m Market Poised for Growth, Projected to Reach Over US$ 8.6 Billion by 2034 | Transparency Market Research
  5. DrugBank: Technetium Tc-99m medronate

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