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Last Updated: February 7, 2023

CLINICAL TRIALS PROFILE FOR TAZVERIK


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All Clinical Trials for Tazverik

Trial ID Title Status Sponsor Phase Start Date Summary
NCT04537715 ↗ A Two-part Study to Characterize Drug-Drug Interaction Effects on Steady-State Pharmacokinetics of Oral Tazemetostat Recruiting Epizyme, Inc. Phase 1 2020-04-23 This is a phase I, multi-center, open-label, multi-dose, two-part PK and safety study to characterize the DDI potential of oral Tazemetostat.
NCT04557956 ↗ Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment Recruiting National Cancer Institute (NCI) Phase 1/Phase 2 2021-02-01 This phase I/II trial investigates the best dose, possible benefits and/or side effects of tazemetostat in combination with dabrafenib and trametinib in treating patients with melanoma that has a specific mutation in the BRAF gene (BRAFV600) and that has spread to other places in the body (metastatic). Tazemetostat, dabrafenib, and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving tazemetostat in combination with dabrafenib and trametinib may stabilize BRAFV600 mutated melanoma.
NCT04624113 ↗ Tazemetostat and Pembrolizumab in Patients With Pembrolizumab- or Nivolumab-Resistant, Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma Recruiting Epizyme, Inc. Phase 1/Phase 2 2021-04-14 The primary aim of the phase 1 portion of the trial is to establish the recommended phase 2 dose (RP2D) of tazemetostat in combination with a fixed dose of pembrolizumab in patients with recurrent or metastatic (RM) head and neck cancer. The primary aim of the phase 2 portion of the trial is to establish the proportion of patients with pembrolizumab- or nivolumab-resistant, PD-L1 positive, RM head and neck squamous-cell carcinoma (HNSCC) who achieve an objective tumor response to tazemetostat and pembrolizumab.
NCT04624113 ↗ Tazemetostat and Pembrolizumab in Patients With Pembrolizumab- or Nivolumab-Resistant, Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma Recruiting Washington University School of Medicine Phase 1/Phase 2 2021-04-14 The primary aim of the phase 1 portion of the trial is to establish the recommended phase 2 dose (RP2D) of tazemetostat in combination with a fixed dose of pembrolizumab in patients with recurrent or metastatic (RM) head and neck cancer. The primary aim of the phase 2 portion of the trial is to establish the proportion of patients with pembrolizumab- or nivolumab-resistant, PD-L1 positive, RM head and neck squamous-cell carcinoma (HNSCC) who achieve an objective tumor response to tazemetostat and pembrolizumab.
NCT04846478 ↗ Phase Ia/Ib Talazoparib + Tazemetostat for mCRPC Recruiting Epizyme, Inc. Phase 1 2021-06-28 This trial is testing whether molecularly targeted oral medications called talazoparib and tazemetostat can be safely combined for the treatment of prostate cancer, and whether the combination is effective in shrinking or preventing the growth of metastatic prostate cancer. The names of the study drugs involved in this study are: - Talazoparib - Tazemetostat
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Tazverik

Condition Name

Condition Name for Tazverik
Intervention Trials
Follicular Lymphoma 2
Solid Tumor 2
Platinum-Resistant Lung Small Cell Carcinoma 1
Diffuse Large B Cell Lymphoma 1
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Condition MeSH

Condition MeSH for Tazverik
Intervention Trials
Neoplasms 4
Lymphoma 4
Carcinoma 3
Rhabdoid Tumor 2
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Clinical Trial Locations for Tazverik

Trials by Country

Trials by Country for Tazverik
Location Trials
United States 14
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Trials by US State

Trials by US State for Tazverik
Location Trials
Missouri 2
Massachusetts 2
Pennsylvania 1
Georgia 1
Texas 1
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Clinical Trial Progress for Tazverik

Clinical Trial Phase

Clinical Trial Phase for Tazverik
Clinical Trial Phase Trials
Phase 2 3
Phase 1/Phase 2 5
Phase 1 4
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Clinical Trial Status

Clinical Trial Status for Tazverik
Clinical Trial Phase Trials
Not yet recruiting 8
Recruiting 5
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Clinical Trial Sponsors for Tazverik

Sponsor Name

Sponsor Name for Tazverik
Sponsor Trials
Epizyme, Inc. 9
National Cancer Institute (NCI) 2
Susan Chi 1
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Sponsor Type

Sponsor Type for Tazverik
Sponsor Trials
Industry 13
Other 11
NIH 2
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