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Last Updated: May 19, 2022

CLINICAL TRIALS PROFILE FOR TASMAR


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All Clinical Trials for Tasmar

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00044083 ↗ Clinical Trial of Tolcapone for Cognition in Schizophrenia Terminated National Institute of Mental Health (NIMH) Phase 2 2002-08-01 This study will evaluate whether Tolcapone improves cognition in healthy volunteers as well as patients with schizophrenia. Talcapone is a drug that has been FDA approved for Attention Deficit Disorder and allegedly increase the amount of the neurotransmitter dopamine in the frontal cortex of the brain. ...
NCT00604591 ↗ Effects of Tolcapone on Frontotemporal Dementia Completed National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 2011-07-01 This study will test the effects of a medication called tolcapone on cognitive, behavioral, and language problems seen in patients with frontotemporal dementia (FTD). Tolcapone increases the amount of dopamine, a brain chemical that may be lowered in FTD. The study will see if tolcapone can improve thinking, behavior, and language in people with FTD and will look at the effects of the drug on brain activity. Patients with FTD who are between 40 and 85 years of age may be eligible for this study. Participants will be seen as outpatients at the Columbia University Medical Center approximately one a week for 4 weeks. They take tolcapone or a placebo (a look-alike pill with no active ingredient) during study week 1. During study week 3, those who took placebo during week 1 now take tolcapone for 1 week and those who took tolcapone now take placebo. In addition, patients undergo the following tests and procedures: - Neurological tests to evaluate attention, problem-solving and memory. These tests are repeated several times during the course of the study. - Test to look for a gene that affects the amount of dopamine in the brain, using blood samples collected in a previous study. - Blood draws four times during the study. - Functional MRI (fMRI) to learn about changes in brain regions that are involved in performing tasks. For fMRI, the patient lies on a table that can slide in and out of the scanner, a narrow metal cylinder surrounded by a magnetic field. The procedure takes about 60 minutes and is performed four times over the course of the . FMRI involves taking pictures of the brain during MRI while the subject performs a task so that changes in the brain that occur during these tasks can be studied.
NCT00604591 ↗ Effects of Tolcapone on Frontotemporal Dementia Completed Columbia University Phase 2 2011-07-01 This study will test the effects of a medication called tolcapone on cognitive, behavioral, and language problems seen in patients with frontotemporal dementia (FTD). Tolcapone increases the amount of dopamine, a brain chemical that may be lowered in FTD. The study will see if tolcapone can improve thinking, behavior, and language in people with FTD and will look at the effects of the drug on brain activity. Patients with FTD who are between 40 and 85 years of age may be eligible for this study. Participants will be seen as outpatients at the Columbia University Medical Center approximately one a week for 4 weeks. They take tolcapone or a placebo (a look-alike pill with no active ingredient) during study week 1. During study week 3, those who took placebo during week 1 now take tolcapone for 1 week and those who took tolcapone now take placebo. In addition, patients undergo the following tests and procedures: - Neurological tests to evaluate attention, problem-solving and memory. These tests are repeated several times during the course of the study. - Test to look for a gene that affects the amount of dopamine in the brain, using blood samples collected in a previous study. - Blood draws four times during the study. - Functional MRI (fMRI) to learn about changes in brain regions that are involved in performing tasks. For fMRI, the patient lies on a table that can slide in and out of the scanner, a narrow metal cylinder surrounded by a magnetic field. The procedure takes about 60 minutes and is performed four times over the course of the . FMRI involves taking pictures of the brain during MRI while the subject performs a task so that changes in the brain that occur during these tasks can be studied.
NCT00906828 ↗ Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors Completed Swedish Parkinson's Disease Foundation Phase 4 2008-10-01 The purpose of this study is to determine whether oral intake of COMT inhibitors affects the smooth plasma levodopa levels achieved by intestinal levodopa/carbidopa infusion in advanced Parkinson's disease patients. The hypothesis is that COMT inhibitors make plasma concentrations of levodopa more fluctuating.
NCT00906828 ↗ Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors Completed Swedish Society for Medical Research Phase 4 2008-10-01 The purpose of this study is to determine whether oral intake of COMT inhibitors affects the smooth plasma levodopa levels achieved by intestinal levodopa/carbidopa infusion in advanced Parkinson's disease patients. The hypothesis is that COMT inhibitors make plasma concentrations of levodopa more fluctuating.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Tasmar

Condition Name

Condition Name for Tasmar
Intervention Trials
Nicotine Dependence 2
Impulsive Behavior 2
Alcohol Use Disorder 2
Amyloidosis, Leptomeningeal, Transthyretin-Related 1
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Condition MeSH

Condition MeSH for Tasmar
Intervention Trials
Alcoholism 3
Tobacco Use Disorder 3
Brain Injuries, Traumatic 2
Alcohol Drinking 2
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Clinical Trial Locations for Tasmar

Trials by Country

Trials by Country for Tasmar
Location Trials
United States 23
Sweden 1
United Kingdom 1
Switzerland 1
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Trials by US State

Trials by US State for Tasmar
Location Trials
California 5
South Carolina 3
Pennsylvania 3
Connecticut 2
Maryland 2
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Clinical Trial Progress for Tasmar

Clinical Trial Phase

Clinical Trial Phase for Tasmar
Clinical Trial Phase Trials
Phase 4 2
Phase 2 8
Phase 1 3
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Clinical Trial Status

Clinical Trial Status for Tasmar
Clinical Trial Phase Trials
Completed 14
Terminated 2
Unknown status 1
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Clinical Trial Sponsors for Tasmar

Sponsor Name

Sponsor Name for Tasmar
Sponsor Trials
University of California, San Francisco 6
University of California, Berkeley 4
National Institute on Alcohol Abuse and Alcoholism (NIAAA) 2
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Sponsor Type

Sponsor Type for Tasmar
Sponsor Trials
Other 28
NIH 6
U.S. Fed 4
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