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Last Updated: October 18, 2019

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CLINICAL TRIALS PROFILE FOR TASMAR

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Clinical Trials for Tasmar

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00604591 Effects of Tolcapone on Frontotemporal Dementia Active, not recruiting National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 2011-07-01 This study will test the effects of a medication called tolcapone on cognitive, behavioral, and language problems seen in patients with frontotemporal dementia (FTD). Tolcapone increases the amount of dopamine, a brain chemical that may be lowered in FTD. The study will see if tolcapone can improve thinking, behavior, and language in people with FTD and will look at the effects of the drug on brain activity. Patients with FTD who are between 40 and 85 years of age may be eligible for this study. Participants will be seen as outpatients at the Columbia University Medical Center approximately one a week for 4 weeks. They take tolcapone or a placebo (a look-alike pill with no active ingredient) during study week 1. During study week 3, those who took placebo during week 1 now take tolcapone for 1 week and those who took tolcapone now take placebo. In addition, patients undergo the following tests and procedures: - Neurological tests to evaluate attention, problem-solving and memory. These tests are repeated several times during the course of the study. - Test to look for a gene that affects the amount of dopamine in the brain, using blood samples collected in a previous study. - Blood draws four times during the study. - Functional MRI (fMRI) to learn about changes in brain regions that are involved in performing tasks. For fMRI, the patient lies on a table that can slide in and out of the scanner, a narrow metal cylinder surrounded by a magnetic field. The procedure takes about 60 minutes and is performed four times over the course of the . FMRI involves taking pictures of the brain during MRI while the subject performs a task so that changes in the brain that occur during these tasks can be studied.
NCT00604591 Effects of Tolcapone on Frontotemporal Dementia Active, not recruiting Columbia University Phase 2 2011-07-01 This study will test the effects of a medication called tolcapone on cognitive, behavioral, and language problems seen in patients with frontotemporal dementia (FTD). Tolcapone increases the amount of dopamine, a brain chemical that may be lowered in FTD. The study will see if tolcapone can improve thinking, behavior, and language in people with FTD and will look at the effects of the drug on brain activity. Patients with FTD who are between 40 and 85 years of age may be eligible for this study. Participants will be seen as outpatients at the Columbia University Medical Center approximately one a week for 4 weeks. They take tolcapone or a placebo (a look-alike pill with no active ingredient) during study week 1. During study week 3, those who took placebo during week 1 now take tolcapone for 1 week and those who took tolcapone now take placebo. In addition, patients undergo the following tests and procedures: - Neurological tests to evaluate attention, problem-solving and memory. These tests are repeated several times during the course of the study. - Test to look for a gene that affects the amount of dopamine in the brain, using blood samples collected in a previous study. - Blood draws four times during the study. - Functional MRI (fMRI) to learn about changes in brain regions that are involved in performing tasks. For fMRI, the patient lies on a table that can slide in and out of the scanner, a narrow metal cylinder surrounded by a magnetic field. The procedure takes about 60 minutes and is performed four times over the course of the . FMRI involves taking pictures of the brain during MRI while the subject performs a task so that changes in the brain that occur during these tasks can be studied.
NCT00906828 Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors Completed Swedish Parkinson's Disease Foundation Phase 4 2008-10-01 The purpose of this study is to determine whether oral intake of COMT inhibitors affects the smooth plasma levodopa levels achieved by intestinal levodopa/carbidopa infusion in advanced Parkinson's disease patients. The hypothesis is that COMT inhibitors make plasma concentrations of levodopa more fluctuating.
NCT00906828 Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors Completed Swedish Society for Medical Research Phase 4 2008-10-01 The purpose of this study is to determine whether oral intake of COMT inhibitors affects the smooth plasma levodopa levels achieved by intestinal levodopa/carbidopa infusion in advanced Parkinson's disease patients. The hypothesis is that COMT inhibitors make plasma concentrations of levodopa more fluctuating.
NCT00906828 Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors Completed Uppsala University Phase 4 2008-10-01 The purpose of this study is to determine whether oral intake of COMT inhibitors affects the smooth plasma levodopa levels achieved by intestinal levodopa/carbidopa infusion in advanced Parkinson's disease patients. The hypothesis is that COMT inhibitors make plasma concentrations of levodopa more fluctuating.
NCT01001520 Neural Substrates in Nicotine Withdrawal Completed National Institute on Drug Abuse (NIDA) Phase 2 2010-01-01 This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit. This study will also determine whether the benefits of this medication differ depending on a smokers' genetic background.
NCT01001520 Neural Substrates in Nicotine Withdrawal Completed University of Pennsylvania Phase 2 2010-01-01 This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit. This study will also determine whether the benefits of this medication differ depending on a smokers' genetic background.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Tasmar

Condition Name

Condition Name for Tasmar
Intervention Trials
Impulsive Behavior 2
Alcohol Use Disorder 2
Nicotine Dependence 2
Brain Injuries, Traumatic 1
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Condition MeSH

Condition MeSH for Tasmar
Intervention Trials
Tobacco Use Disorder 3
Alcoholism 2
Impulsive Behavior 2
Alcohol Drinking 2
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Clinical Trial Locations for Tasmar

Trials by Country

Trials by Country for Tasmar
Location Trials
United States 21
United Kingdom 1
Switzerland 1
Sweden 1
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Trials by US State

Trials by US State for Tasmar
Location Trials
California 5
Pennsylvania 3
South Carolina 3
Connecticut 2
Missouri 1
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Clinical Trial Progress for Tasmar

Clinical Trial Phase

Clinical Trial Phase for Tasmar
Clinical Trial Phase Trials
Phase 4 1
Phase 2 6
Phase 1 3
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Clinical Trial Status

Clinical Trial Status for Tasmar
Clinical Trial Phase Trials
Completed 5
Active, not recruiting 4
Recruiting 4
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Clinical Trial Sponsors for Tasmar

Sponsor Name

Sponsor Name for Tasmar
Sponsor Trials
University of California, San Francisco 5
University of California, Berkeley 3
Corino Therapeutics, Inc. 2
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Sponsor Type

Sponsor Type for Tasmar
Sponsor Trials
Other 23
NIH 3
Industry 3
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