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Last Updated: September 19, 2021

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CLINICAL TRIALS PROFILE FOR TARGRETIN

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505(b)(2) Clinical Trials for Targretin

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Combination NCT01504490 ↗ Phase I Study of CS-7017 and Bexarotene Terminated Daiichi Sankyo Inc. Phase 1 2011-12-01 This study is for patients with advanced solid tumors. The purpose of this study is to test the safety and effectiveness of a new combination of drugs, CS-7017 and Bexarotene in patients with advanced cancer. CS-7017 and Bexarotene both have many effects on cancer cells, including stopping cancer cells from growing and dividing, and causing the cancer cells to die. CS-7017 and Bexarotene work on cancer cells in a similar manner and both drugs together may have an even greater effect against cancer cells, hopefully, increasing the killing of cancer cells. CS-7017 is an investigational or experimental anti-cancer agent that has not yet been approved by the Food and Drug Administration (FDA) for use in any type of cancer. Bexarotene is an anti-cancer agent that has been approved by the FDA for patients with a specific type of cancer, cutaneous T-cell lymphoma. This study will help find out what effects the combination of drugs, CS-7017 and Bexarotene, has on cancer. This research is being done because it is not known if CS-7017 is safe to be given with Bexarotene.
New Combination NCT01504490 ↗ Phase I Study of CS-7017 and Bexarotene Terminated Georgetown University Phase 1 2011-12-01 This study is for patients with advanced solid tumors. The purpose of this study is to test the safety and effectiveness of a new combination of drugs, CS-7017 and Bexarotene in patients with advanced cancer. CS-7017 and Bexarotene both have many effects on cancer cells, including stopping cancer cells from growing and dividing, and causing the cancer cells to die. CS-7017 and Bexarotene work on cancer cells in a similar manner and both drugs together may have an even greater effect against cancer cells, hopefully, increasing the killing of cancer cells. CS-7017 is an investigational or experimental anti-cancer agent that has not yet been approved by the Food and Drug Administration (FDA) for use in any type of cancer. Bexarotene is an anti-cancer agent that has been approved by the FDA for patients with a specific type of cancer, cutaneous T-cell lymphoma. This study will help find out what effects the combination of drugs, CS-7017 and Bexarotene, has on cancer. This research is being done because it is not known if CS-7017 is safe to be given with Bexarotene.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Targretin

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00002212 ↗ A Study of Targretin Capsules in Patients With AIDS-Related Kaposi's Sarcoma Completed Ligand Pharmaceuticals Phase 2 1969-12-31 The purpose of this study is to see if it is safe and effective to give Targretin capsules to patients with AIDS-related Kaposi's sarcoma (KS).
NCT00003752 ↗ Bexarotene in Treating Patients With Metastatic Breast Cancer Completed Ligand Pharmaceuticals Phase 2 1998-10-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Randomized phase II trial to study the effectiveness of bexarotene in treating patients who have metastatic breast cancer.
NCT00030589 ↗ Chemotherapy and Photodynamic Therapy in Treating Patients With Cutaneous T-Cell Lymphoma Unknown status Millennix Phase 2 2001-02-01 RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill cancer cells. Photosensitizing drugs, such as methoxsalen, are absorbed by cancer cells and, when exposed to light, become active and kill the cancer cells. Combining chemotherapy with photodynamic therapy may be an effective treatment for cutaneous T-cell lymphoma. PURPOSE: Randomized phase II trial to study the effectiveness of combining different doses of bexarotene with photodynamic therapy in treating patients who have stage IB or stage IIA cutaneous T-cell lymphoma.
NCT00030849 ↗ Bexarotene and Interferon Alfa in Treating Patients With Cutaneous T-Cell Lymphoma Completed National Cancer Institute (NCI) Phase 2 2001-10-01 RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Combining chemotherapy with interferon alfa may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combining bexarotene with interferon alfa in treating patients who have cutaneous T-cell lymphoma.
NCT00030849 ↗ Bexarotene and Interferon Alfa in Treating Patients With Cutaneous T-Cell Lymphoma Completed Memorial Sloan Kettering Cancer Center Phase 2 2001-10-01 RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Combining chemotherapy with interferon alfa may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combining bexarotene with interferon alfa in treating patients who have cutaneous T-cell lymphoma.
NCT00050960 ↗ Evaluation of Efficacy, Safety and Tolerability of Targretin Capsules in Patients With Advanced or Metastatic Non-small Cell Lung Cancer Completed Eisai Inc. Phase 3 2002-05-01 This study evaluates the use of Targretin capsules (bexarotene) in combination with standard chemotherapy for the treatment of metastatic Non-Small Cell Lung Cancer (NSCLC) in patients who have not yet received chemotherapy for their lung cancer.
NCT00050973 ↗ Evaluation of Efficacy, Safety and Tolerability of Targretin Capsules in Patients With Advanced or Metastatic Non-small Cell Lung Cancer Completed Eisai Inc. Phase 3 1969-12-31 This study evaluates the use of Targretin capsules (bexarotene) in combination with standard chemotherapy for the treatment of metastatic Non-Small Cell Lung Cancer (NSCLC) in patients who have not yet received chemotherapy for their lung cancer.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Targretin

Condition Name

Condition Name for Targretin
Intervention Trials
Lymphoma 6
Schizophrenia 3
Carcinoma, Non-small-cell Lung 3
Lung Cancer 2
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Condition MeSH

Condition MeSH for Targretin
Intervention Trials
Lymphoma, T-Cell, Cutaneous 7
Lymphoma, T-Cell 7
Lymphoma 7
Carcinoma, Non-Small-Cell Lung 7
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Clinical Trial Locations for Targretin

Trials by Country

Trials by Country for Targretin
Location Trials
United States 138
Israel 6
Canada 6
United Kingdom 5
Australia 5
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Trials by US State

Trials by US State for Targretin
Location Trials
Texas 11
New York 9
Louisiana 7
California 7
Florida 7
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Clinical Trial Progress for Targretin

Clinical Trial Phase

Clinical Trial Phase for Targretin
Clinical Trial Phase Trials
Phase 4 1
Phase 3 7
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Targretin
Clinical Trial Phase Trials
Completed 14
Terminated 6
Unknown status 3
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Clinical Trial Sponsors for Targretin

Sponsor Name

Sponsor Name for Targretin
Sponsor Trials
Ligand Pharmaceuticals 8
National Cancer Institute (NCI) 5
Dartmouth-Hitchcock Medical Center 4
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Sponsor Type

Sponsor Type for Targretin
Sponsor Trials
Other 24
Industry 21
NIH 5
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