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US Department of Justice
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Mallinckrodt
Baxter
Farmers Insurance
AstraZeneca
Covington
Cantor Fitzgerald
McKesson

Generated: December 15, 2018

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CLINICAL TRIALS PROFILE FOR SYNRIBO

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Clinical Trials for Synribo

Trial ID Title Status Sponsor Phase Summary
NCT00375219 Homoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene Mutation Completed Cephalon Phase 2 To evaluate the safety and efficacy of subcutaneous administration of omacetaxine mepesuccinate (HHT) in achieving a clinical response in CML patients in chronic, accelerated, or blast phase who have failed prior imatinib therapy and have the T315I kinase domain gene mutation.
NCT00375219 Homoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene Mutation Completed ChemGenex Pharmaceuticals Phase 2 To evaluate the safety and efficacy of subcutaneous administration of omacetaxine mepesuccinate (HHT) in achieving a clinical response in CML patients in chronic, accelerated, or blast phase who have failed prior imatinib therapy and have the T315I kinase domain gene mutation.
NCT00375219 Homoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene Mutation Completed Teva Branded Pharmaceutical Products, R&D Inc. Phase 2 To evaluate the safety and efficacy of subcutaneous administration of omacetaxine mepesuccinate (HHT) in achieving a clinical response in CML patients in chronic, accelerated, or blast phase who have failed prior imatinib therapy and have the T315I kinase domain gene mutation.
NCT00462943 Open Label Study of Subcutaneous Homoharringtonine (Omacetaxine Mepesuccinate) in Patients With Advanced CML Completed Cephalon Phase 2 A Phase II open-label trial of subcutaneous HHT (omacetaxine mepesuccinate) in the treatment of patients who are resistant to or intolerant to Tyrosine Kinase Inhibitors.
NCT00462943 Open Label Study of Subcutaneous Homoharringtonine (Omacetaxine Mepesuccinate) in Patients With Advanced CML Completed ChemGenex Pharmaceuticals Phase 2 A Phase II open-label trial of subcutaneous HHT (omacetaxine mepesuccinate) in the treatment of patients who are resistant to or intolerant to Tyrosine Kinase Inhibitors.
NCT00462943 Open Label Study of Subcutaneous Homoharringtonine (Omacetaxine Mepesuccinate) in Patients With Advanced CML Completed Teva Branded Pharmaceutical Products, R&D Inc. Phase 2 A Phase II open-label trial of subcutaneous HHT (omacetaxine mepesuccinate) in the treatment of patients who are resistant to or intolerant to Tyrosine Kinase Inhibitors.
NCT01873495 Omacetaxine for Consolidation and Maintenance Recruiting Teva Pharmaceuticals USA N/A The purpose of this pilot study is to assess the safety and tolerability of omacetaxine for consolidation in patients age 55 and older with acute myelogenous leukemia (AML) in first complete remission following induction with cytarabine and daunorubicin, and also to assess the safety and tolerability of omacetaxine for maintenance in patients age 55 and older with acute AML in first complete remission following 3 consolidation courses with omacetaxine.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Synribo

Condition Name

Condition Name for Synribo
Intervention Trials
Leukemia 2
Chronic Myeloid Leukemia 2
Myelodysplastic Syndromes 1
Acute Myelogenous Leukemia (AML) 1
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Condition MeSH

Condition MeSH for Synribo
Intervention Trials
Leukemia, Myeloid 4
Leukemia 3
Preleukemia 3
Myelodysplastic Syndromes 3
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Clinical Trial Locations for Synribo

Trials by Country

Trials by Country for Synribo
Location Trials
United States 20
France 2
India 2
Singapore 2
Canada 2
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Trials by US State

Trials by US State for Synribo
Location Trials
Texas 4
Pennsylvania 2
New York 2
Maryland 2
Indiana 2
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Clinical Trial Progress for Synribo

Clinical Trial Phase

Clinical Trial Phase for Synribo
Clinical Trial Phase Trials
Phase 2 4
Phase 1/Phase 2 1
N/A 1
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Clinical Trial Status

Clinical Trial Status for Synribo
Clinical Trial Phase Trials
Recruiting 2
Completed 2
Withdrawn 1
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Clinical Trial Sponsors for Synribo

Sponsor Name

Sponsor Name for Synribo
Sponsor Trials
Teva Pharmaceuticals USA 3
Teva Branded Pharmaceutical Products, R&D Inc. 2
ChemGenex Pharmaceuticals 2
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Sponsor Type

Sponsor Type for Synribo
Sponsor Trials
Industry 10
Other 4
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Serving hundreds of leading biopharmaceutical companies globally:

Accenture
AstraZeneca
Harvard Business School
Fuji
Healthtrust
Teva
Colorcon
Daiichi Sankyo
US Department of Justice

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