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Generated: March 21, 2019

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CLINICAL TRIALS PROFILE FOR SUCCIMER

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Clinical Trials for Succimer

Trial ID Title Status Sponsor Phase Summary
NCT00004838 Randomized Study of Succimer (Dimercaptosuccinic Acid) on Growth of Lead-Poisoned Children Completed Nationwide Children's Hospital N/A OBJECTIVES: Compare growth of lead-poisoned children receiving succimer (dimercaptosuccinic acid; DMSA) plus standard treatment to those receiving standard treatment only.
NCT00004838 Randomized Study of Succimer (Dimercaptosuccinic Acid) on Growth of Lead-Poisoned Children Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) N/A OBJECTIVES: Compare growth of lead-poisoned children receiving succimer (dimercaptosuccinic acid; DMSA) plus standard treatment to those receiving standard treatment only.
NCT00342849 Treatment of Lead-Exposed Children Trial Completed National Institute of Environmental Health Sciences (NIEHS) Phase 3 The Treatment of Lead-Exposed Children (TLC) clinical trial compared the effect of lead chelation with succimer to placebo therapy. TLC was a randomized, double-blind, placebo-controlled clinical trial with sites in Cincinnati and Columbus, Ohio, Philadelphia, Pennsylvania, Baltimore, Maryland and Newark, New Jersey. The study was designed to test outcomes in IQ, neuropsychological function, behavior, physical growth and blood pressure three years after initiation of treatment. Enrollment was conducted between 1994 and 1997, with completion of the initial three-year follow-up in 2000.
NCT00376194 Mercury Chelation to Treat Autism Withdrawn National Institute of Mental Health (NIMH) Phase 2 This study will examine whether DMSA, an oral chelating agent that removes mercury and other metals from the body, is beneficial for children with autism. DMSA is commonly used to treat autism, although it has never been tested in a controlled study and there is no proof that it helps children with the disorder. Support for its use is based on single-case reports of benefits of chelation with DMSA. This study will help determine whether or not DMSA is useful for treating autism. Children between 4 and 10 years of age with autism spectrum disorder who weigh at least 33 pounds, who have detectable, but not toxic, levels of mercury or lead in the blood, and who have not previously received chelation therapy may be eligible for this study. Participants complete a medical history, behavioral and psychological assessment and physical examination. Blood, hair, urine and stool samples are collected for testing. Because DMSA can remove minerals the body needs, such as zinc and iron, as well as the toxic lead and mercury, participants take a daily multivitamin supplement starting 1 month before beginning chelation therapy and continuing for the duration of treatment. After 1 month of the supplementation regimen, the children are assigned to receive DMSA or placebo for 12 weeks, divided into six 2-week cycles. They take the assigned drug 3 times a day on days 1, 2 and 3 of each cycle and continue the multivitamin every day. The children are seen in the clinic immediately before and after the first, third and sixth cycles. At each checkup, the parent or guardian answers a set of questions about the child's autism symptoms, physical health and medication side effects. Blood, urine and stool samples are collected for laboratory testing.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Succimer

Condition Name

Condition Name for Succimer
Intervention Trials
Autism 2
Lead Poisoning 2
Lead Exposure 1
Acute Myeloid Leukemia 1
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Condition MeSH

Condition MeSH for Succimer
Intervention Trials
Poisoning 2
Lead Poisoning 2
Autistic Disorder 2
Leukemia, Myelomonocytic, Juvenile 1
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Clinical Trial Locations for Succimer

Trials by Country

Trials by Country for Succimer
Location Trials
United States 8
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Trials by US State

Trials by US State for Succimer
Location Trials
Maryland 2
Texas 1
Arizona 1
Massachusetts 1
Pennsylvania 1
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Clinical Trial Progress for Succimer

Clinical Trial Phase

Clinical Trial Phase for Succimer
Clinical Trial Phase Trials
Phase 3 1
Phase 2/Phase 3 1
Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Succimer
Clinical Trial Phase Trials
Completed 3
Withdrawn 2
Recruiting 1
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Clinical Trial Sponsors for Succimer

Sponsor Name

Sponsor Name for Succimer
Sponsor Trials
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1
National Cancer Institute (NCI) 1
Nationwide Children's Hospital 1
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Sponsor Type

Sponsor Type for Succimer
Sponsor Trials
NIH 4
Other 3
U.S. Fed 1
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