National Institute of Environmental Health Sciences (NIEHS)
The Treatment of Lead-Exposed Children (TLC) clinical trial compared the effect of lead
chelation with succimer to placebo therapy. TLC was a randomized, double-blind,
placebo-controlled clinical trial with sites in Cincinnati and Columbus, Ohio, Philadelphia,
Pennsylvania, Baltimore, Maryland and Newark, New Jersey. The study was designed to test
outcomes in IQ, neuropsychological function, behavior, physical growth and blood pressure
three years after initiation of treatment. Enrollment was conducted between 1994 and 1997,
with completion of the initial three-year follow-up in 2000.
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