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Last Updated: March 19, 2024

CLINICAL TRIALS PROFILE FOR SPIRONOLACTONE


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All Clinical Trials for Spironolactone

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00001202 ↗ Treatment of Boys With Precocious Puberty Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 2 1985-01-01 This study is a continuation of two previous studies conducted at the NIH. The first study , "Treatment of True Precocious Puberty with a Long-Acting Lutenizing Hormone Releasing Hormone Analog (D-Trp(6)-Pro(9)-Net-LHRH)" had less than optimal results. Some patients, all of whom were diagnosed with familial isosexual precocious puberty, had an inadequate response to the medication and were observed to have high levels of testosterone, advanced bone aging, and other complications of the disease. As a result these patients were enrolled in a second study In the second study, "Spironolactone Treatment for Boys with Familial Isosexual Precocious Puberty", - the patients received another medication, spironolactone (Aldactone). The drug blocked the effects of testosterone, -but bone age advancement did not improve. Some patients began experiencing gynecomastia (an abnormal growth of the male breasts). Researchers believe these may be the effects of elevated levels of estrodiol (a form of the female hormone, estrogen). In the present study, testolactone is added to the drug regimen to block the production of estrogen. The study therefore uses spironolactone to prevent the action of the male hormones (androgen) and testolactone to block the production of female hormones (estrogen). Deslorelin, an LHRH analog which works by turning off true (central) puberty, is added to the drug regimen once true puberty begins. This is because it is know that boys with familial male precocious puberty go into true puberty too early (despite treatment with spironolactone and testolactone), and when that happens, the spironolactone and testolactone are no longer as effective. The goal of the treatment is to delay sexual development until a more appropriate age and prevent short adult stature (height).
NCT00004311 ↗ Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome Completed Baylor College of Medicine Phase 2 1989-07-01 OBJECTIVES: I. Evaluate insulin resistance in thin and obese hyperandrogenic women with polycystic ovarian disease or hyperandrogenism insulin resistance acanthosis nigricans syndrome and in thin and obese controls, using an estimation of tissue sensitivity to insulin. II. Evaluate the effect of androgen suppression with leuprolide acetate and spironolactone on insulin secretion and resistance.
NCT00004311 ↗ Phase II Study of the Effect of Leuprolide Acetate and Spironolactone on Insulin Resistance in Hyperandrogenic Women With Polycystic Ovarian Disease or Hyperandrogenism Insulin Resistance Acanthosis Nigricans Syndrome Completed National Center for Research Resources (NCRR) Phase 2 1989-07-01 OBJECTIVES: I. Evaluate insulin resistance in thin and obese hyperandrogenic women with polycystic ovarian disease or hyperandrogenism insulin resistance acanthosis nigricans syndrome and in thin and obese controls, using an estimation of tissue sensitivity to insulin. II. Evaluate the effect of androgen suppression with leuprolide acetate and spironolactone on insulin secretion and resistance.
NCT00007592 ↗ Hypertension Screening and Treatment Program Completed US Department of Veterans Affairs 1989-06-01 Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Spironolactone

Condition Name

Condition Name for Spironolactone
Intervention Trials
Hypertension 28
Heart Failure 24
Polycystic Ovary Syndrome 10
Ascites 7
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Condition MeSH

Condition MeSH for Spironolactone
Intervention Trials
Heart Failure 50
Hypertension 44
Kidney Diseases 24
Renal Insufficiency, Chronic 18
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Clinical Trial Locations for Spironolactone

Trials by Country

Trials by Country for Spironolactone
Location Trials
United States 256
Canada 28
Germany 25
United Kingdom 22
Brazil 19
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Trials by US State

Trials by US State for Spironolactone
Location Trials
Texas 17
Massachusetts 14
California 13
New York 13
Pennsylvania 13
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Clinical Trial Progress for Spironolactone

Clinical Trial Phase

Clinical Trial Phase for Spironolactone
Clinical Trial Phase Trials
Phase 4 89
Phase 3 34
Phase 2/Phase 3 9
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Clinical Trial Status

Clinical Trial Status for Spironolactone
Clinical Trial Phase Trials
Completed 129
Recruiting 36
Unknown status 33
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Clinical Trial Sponsors for Spironolactone

Sponsor Name

Sponsor Name for Spironolactone
Sponsor Trials
National Heart, Lung, and Blood Institute (NHLBI) 14
Brigham and Women's Hospital 9
Vanderbilt University 8
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Sponsor Type

Sponsor Type for Spironolactone
Sponsor Trials
Other 392
Industry 40
NIH 32
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