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Last Updated: January 16, 2025

CLINICAL TRIALS PROFILE FOR SODIUM MONOFLUOROPHOSPHATE


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All Clinical Trials for Sodium Monofluorophosphate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00708097 ↗ In Situ Caries Efficacy of Fluoride Toothpastes Completed GlaxoSmithKline Phase 3 2008-04-01 This study is to evaluate the effect of fluoride dentifrices on enamel with artificial caries lesions in an in situ model
NCT00708123 ↗ In Situ Caries of Fluoride Toothpastes Completed GlaxoSmithKline Phase 3 2007-11-01 This study is to evaluate the effect of fluoride dentifrices on enamel with artificial caries lesions in an in situ model.
NCT00759031 ↗ Investigation of Dental Plaque and Gingival Index Completed Colgate Palmolive Phase 3 2008-02-01 Investigation of inhibitory effect of prototype toothpaste on dental plaque formation via modified gingival margin plaque index method.
NCT01589458 ↗ Fluoride Availability in Saliva After Use of Sodium Fluoride or Monofluorophosphate Toothpastes Completed University of Campinas, Brazil Phase 1 2011-08-01 Considering the widespread use of sodium fluoride (NaF) and monofluorophosphate (MFP) based toothpastes, the present study aim to evaluate F availability in saliva after use of the top-selling Brazilian toothpastes. In a blind, crossover clinical trial study, volunteers will brush their teeth with one of the following toothpastes: 1) non-fluoride toothpaste (negative control group); 2) NaF/silica based toothpaste 3)MFP/calcium carbonate based toothpaste. After brushing, a rinse with purified water will be performed. Unstimulated saliva will be collected before and up to 60 min after brushing. Ionic fluoride and total soluble fluoride (corresponding to the sum of fluoride as ion and as MFP) will be determined after acid treatment of salivary samples to hydrolyze MFP. Fluoride will be determined using an ion selective electrode.
NCT01592851 ↗ Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity Completed GlaxoSmithKline Phase 3 2012-04-01 A study to compare the efficacy of a test dentifrice against a control dentifrice in reducing dentinal hypersensitivity over a two week treatment period.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Sodium Monofluorophosphate

Condition Name

Condition Name for Sodium Monofluorophosphate
Intervention Trials
Dentine Hypersensitivity 5
Caries 4
Dentin Sensitivity 3
Gingivitis 2
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Condition MeSH

Condition MeSH for Sodium Monofluorophosphate
Intervention Trials
Hypersensitivity 9
Dentin Sensitivity 8
Gingivitis 2
Dental Plaque 1
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Clinical Trial Locations for Sodium Monofluorophosphate

Trials by Country

Trials by Country for Sodium Monofluorophosphate
Location Trials
United States 11
Ireland 2
Chile 1
Brazil 1
Egypt 1
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Trials by US State

Trials by US State for Sodium Monofluorophosphate
Location Trials
Indiana 5
Nevada 4
Texas 1
New York 1
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Clinical Trial Progress for Sodium Monofluorophosphate

Clinical Trial Phase

Clinical Trial Phase for Sodium Monofluorophosphate
Clinical Trial Phase Trials
Phase 4 2
Phase 3 11
Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Sodium Monofluorophosphate
Clinical Trial Phase Trials
Completed 17
Unknown status 1
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Clinical Trial Sponsors for Sodium Monofluorophosphate

Sponsor Name

Sponsor Name for Sodium Monofluorophosphate
Sponsor Trials
GlaxoSmithKline 11
University of Campinas, Brazil 2
Egymedicalpedia 1
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Sponsor Type

Sponsor Type for Sodium Monofluorophosphate
Sponsor Trials
Industry 14
Other 5
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Sodium Monofluorophosphate: Clinical Trials, Market Analysis, and Projections

Introduction

Sodium monofluorophosphate (MFP) is a versatile compound widely used in various industries, including dental care, pharmaceuticals, and industrial applications. This article delves into the current clinical trials, market analysis, and future projections for sodium monofluorophosphate.

Clinical Trials Update

Ongoing and Recent Trials

Several clinical trials have been conducted or are ongoing to evaluate the efficacy and safety of sodium monofluorophosphate and related fluoride compounds in dental care.

  • A recent clinical study published in the Journal of Periodontology evaluated the effectiveness of a new toothpaste containing stannous fluoride and EDTA compared to sodium fluoride-containing dentifrices. The study highlighted the importance of regular plaque removal in preventing dental caries and periodontitis, although it did not specifically focus on sodium monofluorophosphate[4].

  • Clinical trials associated with sodium fluoride, a closely related compound, have shown its efficacy in dental health. For instance, trials involving sodium fluoride (NaF) solutions have demonstrated its excellent properties in preventing tooth decay and promoting oral health[1].

Future Directions

Future clinical trials are likely to focus on the comparative efficacy of different fluoride compounds, including sodium monofluorophosphate, in various oral care products. These studies will aim to optimize the formulation and concentration of MFP to enhance its preventive and therapeutic benefits.

Market Analysis

Current Market Size and Segmentation

The global sodium monofluorophosphate market was valued at USD 5 billion in 2023. The market is segmented based on product type (industrial grade, toothpaste grade, etc.), end-users (toothpaste, pharmaceuticals, cosmetics, etc.), and geographical regions (North America, Europe, Asia Pacific, etc.)[5].

  • Toothpaste and Oral Care: The majority of MFP produced is consumed by the toothpaste industry, where it is added as a source of fluoride to prevent cavities. It is also used in mouthwashes and dental flosses[2].

  • Industrial Applications: MFP is used in water treatment, metal finishing, and oil and gas production. The industrial application segment is projected to maintain its dominant position over the forecast period[2].

  • Pharmaceuticals and Cosmetics: The pharmaceutical industry is a significant end-user, with MFP being used in fluoride-based drugs to treat osteoporosis and other bone disorders. The cosmetic industry also uses MFP in hair care, skincare, and makeup products[2].

Regional Market Performance

  • Asia Pacific: This region is the fastest-growing market for sodium monofluorophosphate, driven by rapid industrialization and urbanization in countries like China and India. China is the largest market in this region[2][5].

  • North America and Europe: These regions are expected to grow at a CAGR of 4.8% and 3.9%, respectively, driven by the demand for water treatment chemicals and other industrial applications[2].

  • Latin America and Middle East & Africa: These regions are expected to witness moderate growth due to the presence of undeveloped countries and growing demand for fluoride-based products[2].

Market Projections

Growth Rate and Forecast

The global sodium monofluorophosphate market is projected to grow at a CAGR of 5.73% from 2024 to 2031, reaching a value of USD 8.19 billion by 2031[5].

Key Drivers

  • Increasing Demand for Fluoride-Based Products: Rising awareness about dental health and the preventive benefits of fluoride are driving the demand for MFP in toothpaste, mouthwashes, and other oral care products[2][5].

  • Industrial Applications: Growing demand for water treatment, metal finishing, and oil and gas production is also fueling the market growth[2].

  • Pharmaceutical and Cosmetic Uses: The increasing use of fluoride-based drugs and cosmetics is another significant driver of the market[2].

Challenges and Opportunities

  • Raw Material Costs: The price of MFP has been increasing due to the rising cost of phosphate rock, a finite resource. This could pose a challenge to market growth[2].

  • Bulk Supply and Quality Improvement: More suppliers are offering MFP in bulk quantities, making it more affordable. The improving quality of MFP is also making it a more attractive option for buyers[2].

Competitive Landscape

The global sodium monofluorophosphate market is competitive, with several key players including Top Pharm Chemical Group, Hubei Xingfa Chemicals Group, Wuxi Ruiyuan Chemical, and others. These companies are investing in research and development to improve the quality and applications of MFP[2].

Key Takeaways

  • Clinical Trials: Ongoing and future trials will focus on optimizing the use of MFP in oral care products.
  • Market Size: The global MFP market was valued at USD 5 billion in 2023 and is projected to reach USD 8.19 billion by 2031.
  • Segmentation: The market is segmented by product type, end-users, and geographical regions.
  • Regional Performance: Asia Pacific is the fastest-growing region, driven by industrialization and urbanization.
  • Growth Drivers: Increasing demand for fluoride-based products, industrial applications, and pharmaceutical uses are key drivers.
  • Challenges: Rising raw material costs could pose a challenge, but bulk supply and quality improvements offer opportunities.

FAQs

What are the primary uses of sodium monofluorophosphate?

Sodium monofluorophosphate is primarily used in toothpaste and other oral care products to prevent cavities, in industrial applications such as water treatment and metal finishing, and in pharmaceuticals to treat bone disorders.

Which region is the fastest-growing market for sodium monofluorophosphate?

The Asia Pacific region is the fastest-growing market for sodium monofluorophosphate, driven by rapid industrialization and urbanization in countries like China and India.

What is the projected CAGR of the global sodium monofluorophosphate market from 2024 to 2031?

The global sodium monofluorophosphate market is projected to grow at a CAGR of 5.73% from 2024 to 2031.

What are the key drivers of the sodium monofluorophosphate market?

The key drivers include increasing demand for fluoride-based products, growing industrial applications, and the use of MFP in pharmaceuticals and cosmetics.

Who are the major players in the global sodium monofluorophosphate market?

Major players include Top Pharm Chemical Group, Hubei Xingfa Chemicals Group, Wuxi Ruiyuan Chemical, and others.

Sources

  1. Synapse: Sodium fluoride - Drug Targets, Indications, Patents.
  2. Vantage Market Research: Sodium Monofluorophosphate Market - Global Industry Assessment & Forecast.
  3. JustDial: Sodium Monofluorophosphate Price Starting From Rs 80/Pc.
  4. American Academy of Periodontology: New Clinical Study Suggests Effectiveness of New Toothpaste in Combating Gingivitis and Plaque.
  5. Market Research Intellect: Sodium Monofluorophosphate Market Size and Projections.

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