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Generated: December 10, 2018

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CLINICAL TRIALS PROFILE FOR SODIUM BICARBONATE

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Clinical Trials for Sodium Bicarbonate

Trial ID Title Status Sponsor Phase Summary
NCT00045799 Safety & Efficacy of Omeprazole Sodium Bicarbonate for the Prevention of Upper GI Bleeding in the Critically Ill Completed Valeant Pharmaceuticals International, Inc. Phase 3 Critically ill patients are at an increased risk of having upper gastrointestinal (GI) bleeding due to stress related mucosal damage. Cimetidine, delivered continuously through intravenous infusion, is the only drug that the FDA has approved for the prevention of upper GI bleeding in critically ill patients. The present trial is intended to assess the safety and efficacy of an omeprazole sodium bicarbonate immediate-release suspension in this indication.
NCT00130598 PROVOCATION Trial - PROphylactic intraVenOus Hydration for Contrast Agent Toxicity PreventION Completed Swiss National Science Foundation Phase 2/Phase 3 Contrast nephropathy (CN) remains a common complication of radiographic procedures and an important cause of hospital-acquired acute renal failure. Only hydration with saline is uniformly accepted and used in clinical practice as a cornerstone for the prevention of CN. But the optimal preventive strategy for CN is not known. Sodium bicarbonate might be even more effective than hydration with sodium chloride for prophylaxis of CN. Therefore the aim of the study is to evaluate the efficacy of two regimens of sodium bicarbonate compared with a prolonged infusion of sodium chloride in the prevention of CN. Primary endpoint: Decrease in glomerular filtration rate (GFR) within 48 hours.
NCT00130598 PROVOCATION Trial - PROphylactic intraVenOus Hydration for Contrast Agent Toxicity PreventION Completed University Hospital, Basel, Switzerland Phase 2/Phase 3 Contrast nephropathy (CN) remains a common complication of radiographic procedures and an important cause of hospital-acquired acute renal failure. Only hydration with saline is uniformly accepted and used in clinical practice as a cornerstone for the prevention of CN. But the optimal preventive strategy for CN is not known. Sodium bicarbonate might be even more effective than hydration with sodium chloride for prophylaxis of CN. Therefore the aim of the study is to evaluate the efficacy of two regimens of sodium bicarbonate compared with a prolonged infusion of sodium chloride in the prevention of CN. Primary endpoint: Decrease in glomerular filtration rate (GFR) within 48 hours.
NCT00142272 Single Dose Ciprofloxacin in the Treatment of Childhood Cholera:Randomized Controlled Clinical Trial Completed Bayer Phase 3 The study will be conducted to compare the efficacy and safety of a single dose of ciprofloxacin oral suspension 20 mg/kg with a 3-day course of erythromycin oral suspension administered in a dose of 12.5 mg/kg every 6 hours (12 doses) in the treatment of children, aged 2-15 years with clinically severe cholera due to V. cholerae O1 or O139. We hypothesize that single dose ciprofloxacin would result in similar outcome in the clinicalcurewith that of erythromycin given in multiple doses.
NCT00142272 Single Dose Ciprofloxacin in the Treatment of Childhood Cholera:Randomized Controlled Clinical Trial Completed NEMC Phase 3 The study will be conducted to compare the efficacy and safety of a single dose of ciprofloxacin oral suspension 20 mg/kg with a 3-day course of erythromycin oral suspension administered in a dose of 12.5 mg/kg every 6 hours (12 doses) in the treatment of children, aged 2-15 years with clinically severe cholera due to V. cholerae O1 or O139. We hypothesize that single dose ciprofloxacin would result in similar outcome in the clinicalcurewith that of erythromycin given in multiple doses.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Sodium Bicarbonate

Condition Name

Condition Name for Sodium Bicarbonate
Intervention Trials
Contrast Induced Nephropathy 14
Acute Kidney Injury 11
Chronic Kidney Disease 9
Pain 7
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Condition MeSH

Condition MeSH for Sodium Bicarbonate
Intervention Trials
Kidney Diseases 37
Acute Kidney Injury 25
Renal Insufficiency 20
Renal Insufficiency, Chronic 15
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Clinical Trial Locations for Sodium Bicarbonate

Trials by Country

Trials by Country for Sodium Bicarbonate
Location Trials
United States 131
Italy 18
Brazil 13
Australia 12
Korea, Republic of 8
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Trials by US State

Trials by US State for Sodium Bicarbonate
Location Trials
California 10
North Carolina 8
Texas 7
Pennsylvania 7
Ohio 7
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Clinical Trial Progress for Sodium Bicarbonate

Clinical Trial Phase

Clinical Trial Phase for Sodium Bicarbonate
Clinical Trial Phase Trials
Phase 4 44
Phase 3 35
Phase 2/Phase 3 10
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Clinical Trial Status

Clinical Trial Status for Sodium Bicarbonate
Clinical Trial Phase Trials
Completed 79
Recruiting 27
Not yet recruiting 19
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Clinical Trial Sponsors for Sodium Bicarbonate

Sponsor Name

Sponsor Name for Sodium Bicarbonate
Sponsor Trials
Ospedale Misericordia e Dolce 5
Bayer 5
Valeant Pharmaceuticals International, Inc. 5
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Sponsor Type

Sponsor Type for Sodium Bicarbonate
Sponsor Trials
Other 196
Industry 38
NIH 6
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