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CLINICAL TRIALS PROFILE FOR SIMBRINZA

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All Clinical Trials for Simbrinza

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT01937299 ↗	Effect of SIMBRINZA® Suspension as an Added Therapy to TRAVATAN Z®	Completed	Alcon Research	Phase 4	2013-10-01	The purpose of this study is to demonstrate the additive effect of brinzolamide 1%/brimonidine 0.2% (SIMBRINZA® suspension) in subjects with either open angle glaucoma or ocular hypertension who are currently on a prostaglandin analogue (PGA) monotherapy (TRAVATAN Z®).
NCT01937312 ↗	Effect of SIMBRINZA® Suspension as an Added Therapy to a Prostaglandin Analogue	Completed	Alcon Research	Phase 4	2013-10-01	The purpose of this study is to demonstrate the additive effect of brinzolamide 1%/brimonidine 0.2% (SIMBRINZA® suspension) in subjects with either open angle glaucoma or ocular hypertension who are currently on a prostaglandin analogue (PGA) monotherapy.
NCT01978600 ↗	Evaluation of Intraocular Pressure Using Simbrinza™ in Patients With Open-Angle Glaucoma or Ocular Hypertension	Completed	Alcon Research	Phase 4	2013-10-01	The purpose of this study is to evaluate intraocular pressure (IOP) over a 24-hour period using Simbrinza™ topical ophthalmic suspension.
NCT02167035 ↗	Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)	Completed	Allergan	Phase 4	2014-08-01	To compare Combigan Two Times Daily (BID) vs Simbrinza Three Times Daily (TID) in subjects currently being treated with Latanoprost for Open-Angle Glaucoma or Ocular Hypertension. Both of these drugs are currently FDA approved as combination therapy for patients with Open-Angle Glaucoma or Ocular Hypertension. The purpose of this clinical trial would be to assess which treatment, if either, is superior in lowering intraocular pressure (IOP). A secondary objective is to assess the tolerability of each drug.
NCT02167035 ↗	Comparison of Combigan Two Times Daily (BID) Versus Simbrinza Three Times Daily (TID)	Completed	Cornerstone Health Care, PA	Phase 4	2014-08-01	To compare Combigan Two Times Daily (BID) vs Simbrinza Three Times Daily (TID) in subjects currently being treated with Latanoprost for Open-Angle Glaucoma or Ocular Hypertension. Both of these drugs are currently FDA approved as combination therapy for patients with Open-Angle Glaucoma or Ocular Hypertension. The purpose of this clinical trial would be to assess which treatment, if either, is superior in lowering intraocular pressure (IOP). A secondary objective is to assess the tolerability of each drug.
NCT02419508 ↗	SIMBRINZA® Suspension BID as an Adjunctive to Prostaglandin Analogue (PGA)	Completed	Alcon Research	Phase 4	2015-08-07	The purpose of this study is to evaluate the additive intraocular pressure (IOP) lowering effect of brinzolamide 1%/brimonidine 0.2% (dosed twice per day (BID)) when added to a prostaglandin analogue (PGA) in subjects with open-angle glaucoma or ocular hypertension.
NCT02730871 ↗	Safety and Efficacy of SIMBRINZA® BID as an Adjunctive to DUOTRAV®	Terminated	Alcon Research	Phase 4	2016-06-24	The purpose of this study is to evaluate the additive intraocular pressure (IOP) lowering effect of Brinzolamide 1%/Brimonidine 0.2% (SIMBRINZA®) dosed twice daily (BID) when added to Travoprost 0.004%/Timolol 0.5% (DUOTRAV®) in subjects with open-angle glaucoma or ocular hypertension.

Clinical Trial Conditions for Simbrinza

Condition Name

Condition Name for Simbrinza
Intervention	Trials
Ocular Hypertension	7
Open-Angle Glaucoma	3
Glaucoma	3
Open Angle Glaucoma	2

Condition MeSH

Condition MeSH for Simbrinza
Intervention	Trials
Glaucoma	7
Ocular Hypertension	7
Glaucoma, Open-Angle	6
Hypertension	3

Clinical Trial Locations for Simbrinza

Trials by Country

Trials by Country for Simbrinza
Location	Trials
United States	5
Korea, Republic of	1

Trials by US State

Trials by US State for Simbrinza
Location	Trials
Texas	3
North Carolina	2

Clinical Trial Progress for Simbrinza

Clinical Trial Phase

Clinical Trial Phase for Simbrinza
Clinical Trial Phase	Trials
Phase 4	8
Phase 3	1

Clinical Trial Status

Clinical Trial Status for Simbrinza
Clinical Trial Phase	Trials
Completed	7
Recruiting	1
Terminated	1

Clinical Trial Sponsors for Simbrinza

Sponsor Name

Sponsor Name for Simbrinza
Sponsor	Trials
Alcon Research	6
Allergan	1
Cornerstone Health Care, PA	1

Sponsor Type

Sponsor Type for Simbrinza
Sponsor	Trials
Industry	9
Other	1