Irinotecan and Selenium in Treating Patients With Advanced Solid Tumors
Roswell Park Cancer Institute
RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Selenium may allow higher doses of irinotecan to be given. Giving irinotecan together with
selenium may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of selenium when
given together with irinotecan in treating patients with advanced solid tumors.
Selenium in Treating Patients Who Are Undergoing Brachytherapy for Stage I or Stage II Prostate Cancer
National Cancer Institute (NCI)
RATIONALE: The use of nutritional supplements, such as selenium, may stop prostate cancer
from growing. Internal radiation, such as brachytherapy, uses radioactive material placed
directly into or near a tumor to kill tumor cells. Giving selenium before brachytherapy may
be an effective treatment for prostate cancer.
PURPOSE: This randomized phase I trial is studying selenium to see how well it works
compared to placebo in treating patients who are undergoing brachytherapy for stage I or
stage II prostate cancer.
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