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Generated: December 14, 2018

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CLINICAL TRIALS PROFILE FOR SAMARIUM SM-153 LEXIDRONAM PENTASODIUM

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Clinical Trials for Samarium Sm-153 Lexidronam Pentasodium

Trial ID Title Status Sponsor Phase Summary
NCT00245011 Samarium Sm 153 and Stem Cell Transplant Followed By Radiation Therapy Patients With Osteosarcoma Completed National Cancer Institute (NCI) Phase 2 RATIONALE: Radioactive drugs, such as samarium Sm 153 lexidronam pentasodium, may carry radiation directly to tumor cells and not harm normal cells. A peripheral stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy and samarium Sm 153 lexidronam pentasodium. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving samarium Sm 153 lexidronam pentasodium together with a peripheral stem cell transplant and radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving samarium Sm 153 lexidronam pentasodium together with autologous stem cell transplant and radiation therapy works in treating patients with recurrent or refractory, metastatic, or unresectable osteosarcoma.
NCT00245011 Samarium Sm 153 and Stem Cell Transplant Followed By Radiation Therapy Patients With Osteosarcoma Completed Sidney Kimmel Comprehensive Cancer Center Phase 2 RATIONALE: Radioactive drugs, such as samarium Sm 153 lexidronam pentasodium, may carry radiation directly to tumor cells and not harm normal cells. A peripheral stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy and samarium Sm 153 lexidronam pentasodium. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving samarium Sm 153 lexidronam pentasodium together with a peripheral stem cell transplant and radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving samarium Sm 153 lexidronam pentasodium together with autologous stem cell transplant and radiation therapy works in treating patients with recurrent or refractory, metastatic, or unresectable osteosarcoma.
NCT00316940 Samarium 153 and Bortezomib in Treating Patients With Relapsed or Refractory Multiple Myeloma Completed Oncotherapeutics Phase 1 RATIONALE: Radioactive substances, such as samarium 153, may release radiation as it breaks down and kill cancer cells. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Bortezomib may also make tumor cells more sensitive to radiation. Giving samarium 153 together with bortezomib may kill more cancer cells. PURPOSE: This phase I trial is studying the side effects and best dose of samarium 153 when given together with bortezomib in treating patients with relapsed or refractory multiple myeloma.
NCT00365105 Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer Active, not recruiting National Cancer Institute (NCI) Phase 3 RATIONALE: Zoledronate, vitamin D and calcium may prevent or delay bone pain and other symptoms caused by bone metastases. It is not yet known whether giving zoledronate together with vitamin D and calcium is more effective with or without strontium 89 or samarium 153 in treating patients with bone metastases from prostate cancer, lung cancer, or breast cancer. PURPOSE: This randomized phase III trial is studying zoledronate, vitamin D, and calcium to see how well they work compared to zoledronate, vitamin D, calcium, and either strontium 89 or samarium 153 in preventing or delaying bone problems in patients with bone metastases from prostate cancer, lung cancer, or breast cancer.
NCT00365105 Zoledronate, Vitamin D, and Calcium With or Without Strontium 89 or Samarium 153 in Preventing or Delaying Bone Problems in Patients With Bone Metastases From Prostate Cancer, Lung Cancer, or Breast Cancer Active, not recruiting NRG Oncology Phase 3 RATIONALE: Zoledronate, vitamin D and calcium may prevent or delay bone pain and other symptoms caused by bone metastases. It is not yet known whether giving zoledronate together with vitamin D and calcium is more effective with or without strontium 89 or samarium 153 in treating patients with bone metastases from prostate cancer, lung cancer, or breast cancer. PURPOSE: This randomized phase III trial is studying zoledronate, vitamin D, and calcium to see how well they work compared to zoledronate, vitamin D, calcium, and either strontium 89 or samarium 153 in preventing or delaying bone problems in patients with bone metastases from prostate cancer, lung cancer, or breast cancer.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Samarium Sm-153 Lexidronam Pentasodium

Condition Name

Condition Name for Samarium Sm-153 Lexidronam Pentasodium
Intervention Trials
Multiple Myeloma and Plasma Cell Neoplasm 4
Pain 2
Metastatic Cancer 1
Lung Cancer 1
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Condition MeSH

Condition MeSH for Samarium Sm-153 Lexidronam Pentasodium
Intervention Trials
Plasmacytoma 4
Neoplasms, Plasma Cell 4
Multiple Myeloma 4
Prostatic Neoplasms 1
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Clinical Trial Locations for Samarium Sm-153 Lexidronam Pentasodium

Trials by Country

Trials by Country for Samarium Sm-153 Lexidronam Pentasodium
Location Trials
United States 39
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Trials by US State

Trials by US State for Samarium Sm-153 Lexidronam Pentasodium
Location Trials
Minnesota 3
Maryland 3
Florida 2
California 2
North Dakota 1
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Clinical Trial Progress for Samarium Sm-153 Lexidronam Pentasodium

Clinical Trial Phase

Clinical Trial Phase for Samarium Sm-153 Lexidronam Pentasodium
Clinical Trial Phase Trials
Phase 3 1
Phase 2 1
Phase 1/Phase 2 3
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Clinical Trial Status

Clinical Trial Status for Samarium Sm-153 Lexidronam Pentasodium
Clinical Trial Phase Trials
Completed 4
Active, not recruiting 2
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Clinical Trial Sponsors for Samarium Sm-153 Lexidronam Pentasodium

Sponsor Name

Sponsor Name for Samarium Sm-153 Lexidronam Pentasodium
Sponsor Trials
National Cancer Institute (NCI) 5
Mayo Clinic 3
Radiation Therapy Oncology Group 1
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Sponsor Type

Sponsor Type for Samarium Sm-153 Lexidronam Pentasodium
Sponsor Trials
Other 6
NIH 5
Industry 1
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Serving hundreds of leading biopharmaceutical companies globally:

Mallinckrodt
Moodys
UBS
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QuintilesIMS
Johnson and Johnson
Julphar
Fish and Richardson
Harvard Business School

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