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Last Updated: April 30, 2025

CLINICAL TRIALS PROFILE FOR SAFFLOWER OIL


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All Clinical Trials for Safflower Oil

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00004420 ↗ Study of Gammalinolenic Acid for Juvenile Rheumatoid Arthritis Completed University of Massachusetts, Worcester N/A 1994-09-01 OBJECTIVES: I. Determine the efficacy and safety of gammalinolenic acid in the treatment of childhood arthritis.
NCT00004420 ↗ Study of Gammalinolenic Acid for Juvenile Rheumatoid Arthritis Completed FDA Office of Orphan Products Development N/A 1994-09-01 OBJECTIVES: I. Determine the efficacy and safety of gammalinolenic acid in the treatment of childhood arthritis.
NCT00204932 ↗ Effects of CLA Supplements on Body Weight and Fat Oxidation Completed University of Wisconsin, Madison Phase 2 2004-07-01 Conjugated linoleic acid (CLA) is form of fat found in dairy foods, beef and other natural sources. When given to small animals, decreases of body fat have been noted.. Although weight loss is the best treatment for overweight and obesity, it is difficult to maintain the loss in the long term. Because of this, treatment emphasis has turned to small weight losses obtained through non-restrictive diets and prevention of weight regain. This is a study to determine if 6 months of consumption a purified form of CLA will result in greater loss of body fat than control and to determine whether CLA consumption increases total fat oxidation, which would help explain why the weight loss occurs.
NCT00396461 ↗ ICULIP, Influence of Two Lipid Emulsions in the Nosocomial Infection in Critical Patients Terminated B. Braun Medical SA Phase 4 2006-11-01 This study aims to analyse the effect of two total parenteral nutrition diets with lipid emulsions of different compositions on the incidence of nosocomial infection in critical patients. One diet will contain an MCT/LCT emulsion concentrated to 20% (50:50 ratio) and the other will comprise an MCT/LCT/fish oil emulsion (50:40:10 ratio). The secondary objective of this study is to analyse mortality in hospital and up to 6 months of discharge.
NCT00682318 ↗ Effects of Fish Oil and Red Wine on Oxidative Stress Biomarkers Active, not recruiting American Heart Association N/A 2008-05-01 The American Heart Association and the American College of Cardiology (AHA/ACC) recently encouraged "increased consumption of omega-3 fatty acids in the form of fish or capsule form (1 g/day) for risk reduction" and stated that "for treatment of elevated triglycerides, higher doses are usually necessary for risk reduction" (Smith SC et al. Circulation 2006;113:2363-72). These recommendations are based on conflicting evidence about the efficacy of the omega-3 treatment with data derived from single randomized trials or non-randomized studies (Smith SC et al. Circulation 2006;113:2363-72). Much effort has been undertaken to elucidate the role of omega-3 fatty acids in the development of cardiovascular disease, but even recent meta-analyses deliver no clear picture; they either favor (Mozaffarian D Jama 2006;296:1885-99) or reject (Hooper L Bmj 2006;332:752-60) the hypothesis of cardioprotective effects of omega-3 FAs. The objective of the clinical study is to study the effects of fish oil on blood and urinary markers of inflammation and cell stress. By using different permutations of high-dose supplementation of omega-3 and omega-6 fatty acids versus different alimentary omega-3 fish doses and grain alcohol versus different kinds of red wine, this trial will study how omega-3 fatty acids, ethanol and red wine constituents modulate biomarkers of inflammation and cell stress.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Safflower Oil

Condition Name

Condition Name for Safflower Oil
Intervention Trials
Vascular Dementia 2
Glycogen Storage Disease Type V 2
Healthy 1
Juvenile Rheumatoid Arthritis 1
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Condition MeSH

Condition MeSH for Safflower Oil
Intervention Trials
Metabolic Diseases 2
Cholestasis 2
Glycogen Storage Disease Type V 2
Glycogen Storage Disease 2
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Clinical Trial Locations for Safflower Oil

Trials by Country

Trials by Country for Safflower Oil
Location Trials
China 33
Spain 8
United States 5
Denmark 1
Israel 1
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Trials by US State

Trials by US State for Safflower Oil
Location Trials
North Carolina 1
Missouri 1
California 1
Pennsylvania 1
Wisconsin 1
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Clinical Trial Progress for Safflower Oil

Clinical Trial Phase

Clinical Trial Phase for Safflower Oil
Clinical Trial Phase Trials
Phase 4 3
Phase 3 1
Phase 2 6
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Clinical Trial Status

Clinical Trial Status for Safflower Oil
Clinical Trial Phase Trials
Completed 5
Recruiting 3
Terminated 2
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Clinical Trial Sponsors for Safflower Oil

Sponsor Name

Sponsor Name for Safflower Oil
Sponsor Trials
Shineway Pharmaceutical Co.,Ltd 2
Rigshospitalet, Denmark 2
Institut National de la Santé Et de la Recherche Médicale, France 1
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Sponsor Type

Sponsor Type for Safflower Oil
Sponsor Trials
Other 16
Industry 5
U.S. Fed 1
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Safflower Oil: Clinical Trials, Market Analysis, and Projections

Introduction

Safflower oil, derived from the seeds of the safflower plant, has been gaining significant attention due to its versatile applications and numerous health benefits. This article delves into the current state of clinical trials, market analysis, and future projections for safflower oil.

Health Benefits and Clinical Trials

Safflower oil is rich in monounsaturated and polyunsaturated fatty acids, particularly linoleic acid, which makes it a valuable component in various health-related applications. Here are some key health benefits and clinical trial updates:

Cardiovascular Health

Clinical trials have shown that safflower oil can help in reducing the risk of heart diseases by lowering cholesterol levels and improving overall cardiovascular health. The high linoleic acid content in safflower oil is particularly beneficial for heart health, making it an attractive option for those looking to manage cardiovascular conditions[3].

Anti-Inflammatory Effects

Research has highlighted the anti-inflammatory properties of safflower oil, which can be beneficial in pharmaceutical formulations. Studies are ongoing to explore its potential in treating conditions such as skin inflammation and other inflammatory diseases[3].

Skin and Hair Care

Safflower oil's moisturizing and antioxidant properties make it a sought-after ingredient in skincare and haircare products. Clinical trials have demonstrated its effectiveness in promoting skin health, addressing issues like dryness and inflammation, and enhancing hair growth[3].

Market Analysis

Market Size and Growth

The safflower oil market is projected to experience significant growth in the coming years. According to market forecasts, the safflower oil market is expected to reach $3.2 billion by 2025, growing at a CAGR of 6.2% during the forecast period 2020-2025[1]. Another report indicates that the market will reach $293.812 million by 2029, with a CAGR of 5.62% from 2022 to 2029[3].

Geographical Distribution

North America dominated the safflower oil market in 2019, driven by the growing shift towards low-fat foods and changing lifestyles. However, Europe is expected to grow at a higher CAGR during the forecast period due to lower production risks and ease of harvesting and storage[1].

Key Applications

Safflower oil has diverse applications across various industries:

Food & Beverage

It is preferred in the food processing industry for its light flavor, high smoke point, and heart-healthy properties, making it ideal for cooking, frying, and salad dressings[3].

Cosmetic Industry

The oil's moisturizing and antioxidant properties make it a valuable ingredient in skincare and haircare products, addressing skin issues like dryness and inflammation[3].

Pharmaceutical Industry

Safflower oil is used in the formulation of medicinal products due to its potential anti-inflammatory and cholesterol-lowering effects[3].

Industrial Applications

Researchers have identified safflower oil, particularly the Super-High Oleic (SHO) variety, as a potential biodegradable alternative to petroleum in industrial products such as fuels, lubricants, and specialty chemicals[4].

Market Drivers

Increasing Health Consciousness

The rising health consciousness among consumers globally is a major driver for the safflower oil market. Consumers are seeking healthier alternatives to traditional cooking oils and synthetic ingredients in personal care products, which has fueled the demand for safflower oil[3].

Growing Demand for Organic and Natural Products

The increasing preference for organic and natural ingredients in processed foods and personal care products is another significant factor driving the market growth[1].

Commercialization and Versatility

Safflower oil's versatility in various applications, including infant formulas, cosmetics, and edible oils, has increased its commercialization and contributed to market growth[1].

Market Challenges

Harmful Reactions

One of the challenges facing the safflower oil market is the potential for harmful reactions, particularly if not properly diluted before application on the skin[1].

Production and Harvesting

While safflower is a hardy plant with improved drought tolerance, the production and harvesting processes can be challenging, especially in regions with adverse weather conditions[4].

Future Projections

Sustainability and Biodegradability

The development of Super-High Oleic (SHO) safflower oil, which offers superior lubricant properties with lower emissions and reduced friction, is expected to drive innovation in the industrial sector. This biodegradable alternative to petroleum is anticipated to have significant sustainability benefits and export potential[4].

Expanding Applications

Ongoing research and development activities aimed at exploring new applications and enhancing extraction and processing methods are expected to foster sustained growth in the safflower oil market. The alignment of safflower oil with consumer preferences for natural and plant-based products positions it for continued market expansion[3].

Regional Growth

Asia Pacific is expected to be one of the main consumers of safflower oil in the coming years, driven by the growing prevalence of heart diseases and the increasing demand for healthier lifestyle options[5].

Key Takeaways

  • Market Growth: The safflower oil market is projected to reach $3.2 billion by 2025 and $293.812 million by 2029, driven by increasing health consciousness and demand for organic products.
  • Health Benefits: Safflower oil has significant health benefits, including cardiovascular health improvement, anti-inflammatory effects, and skin and hair care advantages.
  • Versatile Applications: The oil is used in the food & beverage, cosmetic, pharmaceutical, and industrial sectors.
  • Sustainability: The development of biodegradable SHO safflower oil offers promising sustainability benefits and industrial applications.
  • Regional Expansion: Asia Pacific and Europe are expected to see significant growth in the safflower oil market.

FAQs

What are the primary health benefits of safflower oil?

Safflower oil is known for its cardiovascular health benefits, anti-inflammatory effects, and its ability to promote skin and hair health.

Which regions dominate the safflower oil market?

North America currently dominates the market, but Europe is expected to grow at a higher CAGR during the forecast period.

What are the key applications of safflower oil?

Safflower oil is used in the food & beverage, cosmetic, pharmaceutical, and industrial sectors.

Is safflower oil a sustainable option?

Yes, particularly the Super-High Oleic (SHO) variety, which offers biodegradable alternatives to petroleum and has significant sustainability benefits.

What drives the demand for safflower oil?

The increasing health consciousness among consumers, the growing demand for organic and natural products, and the oil's versatility in various applications drive the demand for safflower oil.

Sources

  1. IndustryARC: Safflower Oil Production Analysis Market - Forecast(2024 - 2030)
  2. Mordor Intelligence: Safflower Seeds Market Size & Share Analysis
  3. Research and Markets: Safflower Oil Market Size, Competitors & Forecast to 2029
  4. OFI Magazine: Safflower oil's potential as biodegradeable alternative to petroleum…
  5. Allied Market Research: Safflower Market Market Report Size, Value Growth, Share and …

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