Investigation Into Delay to Diagnosis of Alzheimer's Disease With Exelon (InDDEx)
Completed
Novartis
Phase 3
1969-12-31
This phase IIIb trial is a prospective, randomized, double-blind, placebo-controlled,
36-month study comparing the length of time of progression from mild cognitive impairment
(MCI) to a clinical diagnosis of Alzheimer's disease (AD) in subjects taking Exelon vs.
placebo. Exelon is currently under review with the U.S. Food and Drug Administration as a
treatment for Alzheimer's disease. The drug has been cleared for marketing in more than 40
countries for Alzheimer's disease to date, including all 15 member states of the European
Union, New Zealand, Argentina, Brazil and Mexico.
Each subject with MCI will be randomly assigned to treatment with either Exelon or placebo.
Subjects assigned to Exelon will receive 1.5 to 6.0 mg bid (twice daily) (3.0 to 12 mg/day)
for the majority of the study. At every regular visit scheduled every three months, patients
will be given basic efficacy and safety assessments. These assessments will include
evaluation of adverse events, vital signs, activities of daily living, and clinical staging
scales to determine if the subject may have converted to dementia.
Efficacy and Safety of Rivastigmine Capsules in Patients With Probable Vascular Dementia
Completed
Novartis Pharmaceuticals
Phase 3
2001-08-01
The goal of this research study is to evaluate the effectiveness, tolerability and safety of
rivastigmine capsules in males and females between the ages of 50 and 85 years old with
probable vascular dementia.
Efficacy and Safety of the Rivastigmine Transdermal Patch in Patients With Probable Alzheimer's Disease
Completed
Novartis
Phase 3
2003-11-01
The goal of this research study is to evaluate the safety and efficacy of the rivastigmine
transdermal patch in patients with probable Alzheimer's Disease.
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